Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CNGA4 - cyclic nucleotide gated channel alpha 4

Homo sapiens

Synonyms: CNCA2, CNG channel alpha-4, CNG-4, CNG4, CNG5, ...

Trudeau, M.C. et al., Michalakis, S. et al.

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High impact information on CNGA4

This channel contains three types of subunits, the principal CNGA2 subunit and two modulatory subunits (CNGA4 and CNGB1b) [1].

Other interactions of CNGA4

Recent evidence shows that three subunit types (CNGA2, CNGA4, and CNGB1b) make up native olfactory CNG channels and account for the fast inhibition of native channels by Ca2+/CaM [2].

References

Loss of CNGB1 Protein Leads to Olfactory Dysfunction and Subciliary Cyclic Nucleotide-gated Channel Trapping. Michalakis, S., Reisert, J., Geiger, H., Wetzel, C., Zong, X., Bradley, J., Spehr, M., H??ttl, S., Gerstner, A., Pfeifer, A., Hatt, H., Yau, K.W., Biel, M. J. Biol. Chem. (2006) [Pubmed]
Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels. Trudeau, M.C., Zagotta, W.N. J. Biol. Chem. (2003) [Pubmed]

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