Gene Review:
PLK3 - polo-like kinase 3
Homo sapiens
Synonyms:
CNK, Cytokine-inducible serine/threonine-protein kinase, FGF-inducible kinase, FNK, PLK-3, ...
- Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma. Weichert, W., Denkert, C., Schmidt, M., Gekeler, V., Wolf, G., Köbel, M., Dietel, M., Hauptmann, S. Br. J. Cancer (2004)
- Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications. Weichert, W., Kristiansen, G., Winzer, K.J., Schmidt, M., Gekeler, V., Noske, A., Müller, B.M., Niesporek, S., Dietel, M., Denkert, C. Virchows Arch. (2005)
- Epigenetic inactivation implies a tumor suppressor function in hematologic malignancies for Polo-like kinase 2 but not Polo-like kinase 3. Smith, P., Syed, N., Crook, T. Cell Cycle (2006)
- Protection against ischemic brain injury by protein therapeutics. Asoh, S., Ohsawa, I., Mori, T., Katsura, K., Hiraide, T., Katayama, Y., Kimura, M., Ozaki, D., Yamagata, K., Ohta, S. Proc. Natl. Acad. Sci. U.S.A. (2002)
- CP12 provides a new mode of light regulation of Calvin cycle activity in higher plants. Wedel, N., Soll, J., Paap, B.K. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. Wang, Q., Xie, S., Chen, J., Fukasawa, K., Naik, U., Traganos, F., Darzynkiewicz, Z., Jhanwar-Uniyal, M., Dai, W. Mol. Cell. Biol. (2002)
- The effect of early steroid treatment after PRK on clinical and refractive outcomes. Vetrugno, M., Maino, A., Quaranta, G.M., Cardia, L. Acta ophthalmologica Scandinavica. (2001)
- A comparative study of epithelial hyperplasia after PRK: Summit versus VISX in the same patient. Hamberg-Nyström, H., Gauthier, C.A., Holden, B.A., Epstein, D., Fagerholm, P., Tengroth, B. Acta ophthalmologica Scandinavica. (1996)
- Down-regulation of PLK3 gene expression by types and amount of dietary fat in rat colon tumors. Dai, W., Liu, T., Wang, Q., Rao, C.V., Reddy, B.S. Int. J. Oncol. (2002)
- MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3. Xie, S., Wang, Q., Ruan, Q., Liu, T., Jhanwar-Uniyal, M., Guan, K., Dai, W. Oncogene (2004)
- Cell cycle dependent expression of Plk1 in synchronized porcine fetal fibroblasts. Anger, M., Kues, W.A., Klima, J., Mielenz, M., Kubelka, M., Motlik, J., Esner, M., Dvorak, P., Carnwath, J.W., Niemann, H. Mol. Reprod. Dev. (2003)
- Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. Xie, S., Wu, H., Wang, Q., Cogswell, J.P., Husain, I., Conn, C., Stambrook, P., Jhanwar-Uniyal, M., Dai, W. J. Biol. Chem. (2001)
- Polo-like Kinases Inhibited by Wortmannin: LABELING SITE AND DOWNSTREAM EFFECTS. Liu, Y., Jiang, N., Wu, J., Dai, W., Rosenblum, J.S. J. Biol. Chem. (2007)
- Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines. Wiest, J., Clark, A.M., Dai, W. Genes Chromosomes Cancer (2001)
- Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response. Li, Z., Niu, J., Uwagawa, T., Peng, B., Chiao, P.J. J. Biol. Chem. (2005)
- Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2. Xie, S., Wu, H., Wang, Q., Kunicki, J., Thomas, R.O., Hollingsworth, R.E., Cogswell, J., Dai, W. Cell Cycle (2002)
- Physical and functional interactions between mitotic kinases during polyploidization and megakaryocytic differentiation. Huang, X., Ruan, Q., Fang, Y., Traganos, F., Darzynkiewicz, Z., Dai, W. Cell Cycle (2004)
- Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis. Jiang, N., Wang, X., Jhanwar-Uniyal, M., Darzynkiewicz, Z., Dai, W. J. Biol. Chem. (2006)
- Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells. Wang, L., Dai, W., Lu, L. J. Biol. Chem. (2007)
- PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer. Dai, W., Li, Y., Ouyang, B., Pan, H., Reissmann, P., Li, J., Wiest, J., Stambrook, P., Gluckman, J.L., Noffsinger, A., Bejarano, P. Genes Chromosomes Cancer (2000)
- LASIK and PRK malpractice predictors. Probst, L.E. Ophthalmology (2004)
- PRK retreatments after regressed myopic LASIK. Yavitz, E. Ophthalmology (2002)