Gene Review:
CNR1 - cannabinoid receptor 1 (brain)
Homo sapiens
Synonyms:
CANN6, CB-R, CB1, CB1A, CB1K5, ...
Battista,
Gómez del Pulgar,
Di Rienzo,
Sipe,
Foresta,
Baker,
Katona,
Davies,
Hiley,
Guzmán,
Velasco,
Finazzi-Agrò,
Gerber,
Boger,
Cravatt,
Maccarrone,
Freund,
Hoehe,
Gasperi,
Wendel,
Clari,
Rossi,
Finckh,
Arbour,
Beutler,
Pryce,
Ion Popa,
Horodnicki,
Henriksen,
Fiszer-Piosik,
Ferigo,
Samochowiec,
Piomelli,
Guerrieri,
Pertwee,
Rueda,
Galve-Roperh,
Schmidt,
Rossato,
Rommelspacher,
- Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1). Barrero, F.J., Ampuero, I., Morales, B., Vives, F., de Dios Luna Del Castillo, J., Hoenicka, J., García Yébenes, J. Pharmacogenomics J. (2005)
- CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Teixeira-Clerc, F., Julien, B., Grenard, P., Tran Van Nhieu, J., Deveaux, V., Li, L., Serriere-Lanneau, V., Ledent, C., Mallat, A., Lotersztajn, S. Nat. Med. (2006)
- Cannabinoid receptor as a novel target for the treatment of prostate cancer. Sarfaraz, S., Afaq, F., Adhami, V.M., Mukhtar, H. Cancer Res. (2005)
- Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716. Hilairet, S., Bouaboula, M., Carrière, D., Le Fur, G., Casellas, P. J. Biol. Chem. (2003)
- Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Carriba, P., Ortiz, O., Patkar, K., Justinova, Z., Stroik, J., Themann, A., Müller, C., Woods, A.S., Hope, B.T., Ciruela, F., Casadó, V., Canela, E.I., Lluis, C., Goldberg, S.R., Moratalla, R., Franco, R., Ferré, S. Neuropsychopharmacology (2007)
- Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. Schmidt, L.G., Samochowiec, J., Finckh, U., Fiszer-Piosik, E., Horodnicki, J., Wendel, B., Rommelspacher, H., Hoehe, M.R. Drug and alcohol dependence. (2002)
- Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse. Zhang, P.W., Ishiguro, H., Ohtsuki, T., Hess, J., Carillo, F., Walther, D., Onaivi, E.S., Arinami, T., Uhl, G.R. Mol. Psychiatry (2004)
- CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia. Ujike, H., Takaki, M., Nakata, K., Tanaka, Y., Takeda, T., Kodama, M., Fujiwara, Y., Sakai, A., Kuroda, S. Mol. Psychiatry (2002)
- Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. Nong, L., Newton, C., Cheng, Q., Friedman, H., Roth, M.D., Klein, T.W. J. Neuroimmunol. (2002)
- Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1. Leroy, S., Griffon, N., Bourdel, M.C., Olié, J.P., Poirier, M.F., Krebs, M.O. Am. J. Med. Genet. (2001)
- Role of endogenous cannabinoids in synaptic signaling. Freund, T.F., Katona, I., Piomelli, D. Physiol. Rev. (2003)
- Modulation of anxiety through blockade of anandamide hydrolysis. Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., La Rana, G., Calignano, A., Giustino, A., Tattoli, M., Palmery, M., Cuomo, V., Piomelli, D. Nat. Med. (2003)
- Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. Sarnataro, D., Grimaldi, C., Pisanti, S., Gazzerro, P., Laezza, C., Zurzolo, C., Bifulco, M. FEBS Lett. (2005)
- CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains. Mukhopadhyay, S., Howlett, A.C. Eur. J. Biochem. (2001)
- Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence. Herman, A.I., Kranzler, H.R., Cubells, J.F., Gelernter, J., Covault, J. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2006)
- G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. Begg, M., Mo, F.M., Offertaler, L., Bátkai, S., Pacher, P., Razdan, R.K., Lovinger, D.M., Kunos, G. J. Biol. Chem. (2003)
- 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils. Oka, S., Ikeda, S., Kishimoto, S., Gokoh, M., Yanagimoto, S., Waku, K., Sugiura, T. J. Leukoc. Biol. (2004)
- Cannabinoid receptor type 2 gene is associated with human osteoporosis. Karsak, M., Cohen-Solal, M., Freudenberg, J., Ostertag, A., Morieux, C., Kornak, U., Essig, J., Erxlebe, E., Bab, I., Kubisch, C., de Vernejoul, M.C., Zimmer, A. Hum. Mol. Genet. (2005)
- The effects of cannabinoids on the brain. Ameri, A. Prog. Neurobiol. (1999)
- Endocannabinoids and cannabinoid receptor genetics. Onaivi, E.S., Leonard, C.M., Ishiguro, H., Zhang, P.W., Lin, Z., Akinshola, B.E., Uhl, G.R. Prog. Neurobiol. (2002)
- Tuning the oviduct to the anandamide tone. Schuel, H. J. Clin. Invest. (2006)
- Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. Lee, C.V., Hymowitz, S.G., Wallweber, H.J., Gordon, N.C., Billeci, K.L., Tsai, S.P., Compaan, D.M., Yin, J., Gong, Q., Kelley, R.F., Deforge, L.E., Martin, F., Starovasnik, M.A., Fuh, G. Blood (2006)
- An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. Shire, D., Carillon, C., Kaghad, M., Calandra, B., Rinaldi-Carmona, M., Le Fur, G., Caput, D., Ferrara, P. J. Biol. Chem. (1995)
- Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. Gonsiorek, W., Lunn, C., Fan, X., Narula, S., Lundell, D., Hipkin, R.W. Mol. Pharmacol. (2000)
- Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors. Canals, M., Milligan, G. J. Biol. Chem. (2008)
- Novel cannabinol probes for CB1 and CB2 cannabinoid receptors. Mahadevan, A., Siegel, C., Martin, B.R., Abood, M.E., Beletskaya, I., Razdan, R.K. J. Med. Chem. (2000)
- In silico patent searching reveals a new cannabinoid receptor. Baker, D., Pryce, G., Davies, W.L., Hiley, C.R. Trends Pharmacol. Sci. (2006)
- Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules. Boger, D.L., Henriksen, S.J., Cravatt, B.F. Curr. Pharm. Des. (1998)
- Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function. Ellis, J., Pediani, J.D., Canals, M., Milasta, S., Milligan, G. J. Biol. Chem. (2006)
- Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest. Sarfaraz, S., Afaq, F., Adhami, V.M., Malik, A., Mukhtar, H. J. Biol. Chem. (2006)
- Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. Sipe, J.C., Arbour, N., Gerber, A., Beutler, E. J. Leukoc. Biol. (2005)
- Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. Jbilo, O., Derocq, J.M., Segui, M., Le Fur, G., Casellas, P. FEBS Lett. (1999)
- Effect of the cannabinoid receptor ligand, WIN 55,212-2, on superoxide anion and TNF-alpha production by human mononuclear cells. Germain, N., Boichot, E., Advenier, C., Berdyshev, E.V., Lagente, V. Int. Immunopharmacol. (2002)
- Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner. Paradisi, A., Pasquariello, N., Barcaroli, D., Maccarrone, M. J. Biol. Chem. (2008)
- Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor. Galve-Roperh, I., Rueda, D., Gómez del Pulgar, T., Velasco, G., Guzmán, M. Mol. Pharmacol. (2002)
- FOXO1A differentially regulates genes of decidualization. Buzzio, O.L., Lu, Z., Miller, C.D., Unterman, T.G., Kim, J.J. Endocrinology (2006)
- Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Park, B., Gibbons, H.M., Mitchell, M.D., Glassa, M. Placenta (2003)
- Pharmacological actions of cannabinoids. Pertwee, R.G. Handbook of experimental pharmacology. (2005)
- The endocannabinoid system in human keratinocytes. Evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition of protein kinase C, activation protein-1, and transglutaminase. Maccarrone, M., Di Rienzo, M., Battista, N., Gasperi, V., Guerrieri, P., Rossi, A., Finazzi-Agrò, A. J. Biol. Chem. (2003)
- Human sperm express cannabinoid receptor Cb1, the activation of which inhibits motility, acrosome reaction, and mitochondrial function. Rossato, M., Ion Popa, F., Ferigo, M., Clari, G., Foresta, C. J. Clin. Endocrinol. Metab. (2005)
- Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat. Dyson, A., Peacock, M., Chen, A., Courade, J.P., Yaqoob, M., Groarke, A., Brain, C., Loong, Y., Fox, A. Pain (2005)
- Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Gérard, C.M., Mollereau, C., Vassart, G., Parmentier, M. Biochem. J. (1991)
- Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain. Mato, S., Del Olmo, E., Pazos, A. Eur. J. Neurosci. (2003)