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Gene Review

KLF17  -  Kruppel-like factor 17

Homo sapiens

Synonyms: FLJ40160, Krueppel-like factor 17, ZNF393, Zfp393, Zinc finger protein 393
 
 
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High impact information on KLF17

  • We show that human KLF17 can bind G/C-rich sites via its zinc fingers and is able to activate transcription from CACCC-box elements [1].
  • This is the first report of the DNA-binding characteristics and transactivation activity of human KLF17, which, together with the homology it displays to other KLF proteins, put it in the Sp/KLF family [1].
  • The Zfp393 gene consists of three exons spanning approximately 8 kb on the distal part of mouse chromosome 4 [2].
  • Northern blot and RT-PCR analyses revealed that Zfp393 mRNA was exclusively expressed in testis and ovary [2].
 

Analytical, diagnostic and therapeutic context of KLF17

  • Genomic database mining and Southern blot analysis indicate that Zfp393 is a single copy gene [2].

References

  1. Human KLF17 is a new member of the Sp/KLF family of transcription factors. van Vliet, J., Crofts, L.A., Quinlan, K.G., Czolij, R., Perkins, A.C., Crossley, M. Genomics (2006) [Pubmed]
  2. Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein. Yan, W., Burns, K.H., Ma, L., Matzuk, M.M. Mech. Dev. (2002) [Pubmed]
 
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