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Gene Review: 

CHMP4B  -  charged multivesicular body protein 4B

Homo sapiens

Synonyms: C20orf178, CHMP4A, CHMP4b, CTPP3, Charged multivesicular body protein 4b, ...
 
 
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High impact information on CHMP4B

  • The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting [1].
  • Fluorescence microscopic analysis revealed that CHMP4b transiently expressed in HeLa cells mainly exhibited a punctate distribution in the perinuclear area and co-localized with co-expressed Alix [1].
  • The interaction of Alix with CHMP4b was confirmed by a glutathione S-transferase pull-down assay and by co-immunoprecipitation experiments [1].
  • In addition to the previously isolated cDNAs for two CHMP4 proteins (CHMP4a and CHMP4b), we isolated a cDNA for a new member of the CHMP4 subfamily (designated CHMP4c) [2].
  • CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway [3].
 

Anatomical context of CHMP4B

  • Furthermore, CHMP4b co-localized with SKD1(E235Q) as punctate patterns in the perinuclear area, and Alix was induced to exhibit dot-like distributions overlapped with SKD1(E235Q) in HeLa cells [1].
 

Physical interactions of CHMP4B

  • These results suggest that CHMP4b is a major binding partner of Alix among the three CHMP4 isoforms [2].

References

  1. The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. Katoh, K., Shibata, H., Suzuki, H., Nara, A., Ishidoh, K., Kominami, E., Yoshimori, T., Maki, M. J. Biol. Chem. (2003) [Pubmed]
  2. CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. Katoh, K., Shibata, H., Hatta, K., Maki, M. Arch. Biochem. Biophys. (2004) [Pubmed]
  3. CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway. Horii, M., Shibata, H., Kobayashi, R., Katoh, K., Yorikawa, C., Yasuda, J., Maki, M. Biochem. J. (2006) [Pubmed]
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