Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Crygf - crystallin, gamma F

Mus musculus

Synonyms: 3110001K11Rik, Cryg-2, DGcry-2, Gamma-F-crystallin, Gamma-crystallin F, ...

Graw, J. et al., Graw, J. et al.

Graw, Löster, Puk, Münster, Haubst, Soewarto, Fuchs, Meyer, Nürnberg, Pretsch, Selby, Favor, Wolf, Hrabé de Angelis, Graw, Klopp, Neuhäuser-Klaus, Favor, Löster,

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Disease relevance of Crygf

Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity [1].

High impact information on Crygf

This result is supported by the functional analysis of corresponding expression constructs in cell culture, where the Aey11 and Aey18 alleles did not show a stimulation of the Six3 promotor or an inhibition of the Crygf promoter (as wild-type constructs do) [2].
A T-->A exchange in exon 2 of the Crygf gene leads to a Val-->Glu exchange in codon 38 and was considered to be causative for the cataract phenotype; therefore, Crygf(Rop) has been suggested as the designation for the mutation [1].

Biological context of Crygf

Reporter gene analysis used Crygf and Six3 promoter fragments in front of a luciferase gene and HEK293 cells as recipients [2].

References

Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity. Graw, J., Klopp, N., Neuhäuser-Klaus, A., Favor, J., Löster, J. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters. Graw, J., Löster, J., Puk, O., Münster, D., Haubst, N., Soewarto, D., Fuchs, H., Meyer, B., Nürnberg, P., Pretsch, W., Selby, P., Favor, J., Wolf, E., Hrabé de Angelis, M. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]

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