Gene Review:
Ddit3 - DNA-damage inducible transcript 3
Mus musculus
Synonyms:
C/EBP homoologous protein 10, C/EBP zeta, C/EBP-homologous protein, C/EBP-homologous protein 10, CCAAT/enhancer-binding protein homologous protein, ...
- Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. Price, B.D., Calderwood, S.K. Cancer Res. (1992)
- Upregulation of CHOP-10 (gadd153) expression in the mouse blastocyst as a response to stress. Fontanier-Razzaq, N.C., Hay, S.M., Rees, W.D. Mol. Reprod. Dev. (1999)
- Heat-inducible TNF-alpha gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy. Ito, A., Shinkai, M., Honda, H., Kobayashi, T. Cancer Gene Ther. (2001)
- CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Ron, D., Habener, J.F. Genes Dev. (1992)
- Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., Mori, M. J. Clin. Invest. (2002)
- Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect. Carrière, A., Carmona, M.C., Fernandez, Y., Rigoulet, M., Wenger, R.H., Pénicaud, L., Casteilla, L. J. Biol. Chem. (2004)
- Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-beta during adipogenesis. Tang, Q.Q., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Yan, W., Frank, C.L., Korth, M.J., Sopher, B.L., Novoa, I., Ron, D., Katze, M.G. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Trefoil factor 1 (TFF1/pS2) deficiency activates the unfolded protein response. Torres, L.F., Karam, S.M., Wendling, C., Chenard, M.P., Kershenobich, D., Tomasetto, C., Rio, M.C. Mol. Med. (2002)
- The growth arrest genes gas5, gas6, and CHOP-10 (gadd153) are expressed in the mouse preimplantation embryo. Fleming, J.V., Fontanier, N., Harries, D.N., Rees, W.D. Mol. Reprod. Dev. (1997)
- Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway. Lawson, B., Brewer, J.W., Hendershot, L.M. J. Cell. Physiol. (1998)
- Urea-associated oxidative stress and Gadd153/CHOP induction. Zhang, Z., Yang, X.Y., Cohen, D.M. Am. J. Physiol. (1999)
- Regulation of the C/EBP-related gene gadd153 by glucose deprivation. Carlson, S.G., Fawcett, T.W., Bartlett, J.D., Bernier, M., Holbrook, N.J. Mol. Cell. Biol. (1993)
- Evidence for distinct kinase-mediated pathways in gadd gene responses. Carrier, F., Zhan, Q., Alamo, I., Hanaoka, F., Fornace, A.J. Biochem. Pharmacol. (1998)
- Effect of serum on the down-regulation of CHOP-10 during differentiation of 3T3-L1 preadipocytes. Huang, H., Lane, M.D., Tang, Q.Q. Biochem. Biophys. Res. Commun. (2005)
- Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations. Milhavet, O., Martindale, J.L., Camandola, S., Chan, S.L., Gary, D.S., Cheng, A., Holbrook, N.J., Mattson, M.P. J. Neurochem. (2002)
- Regulated expression and functional role of the transcription factor CHOP (GADD153) in erythroid growth and differentiation. Coutts, M., Cui, K., Davis, K.L., Keutzer, J.C., Sytkowski, A.J. Blood (1999)
- C/EBP Homologous Protein (CHOP) Is Crucial for the Induction of Caspase-11 and the Pathogenesis of Lipopolysaccharide-Induced Inflammatio. Endo, M., Mori, M., Akira, S., Gotoh, T. J. Immunol. (2006)
- Gene profiling during development and after a peripheral nerve traumatism reveals genes specifically induced by injury in dorsal root ganglia. Méchaly, I., Bourane, S., Piquemal, D., Al-Jumaily, M., Ventéo, S., Puech, S., Scamps, F., Valmier, J., Carroll, P. Mol. Cell. Neurosci. (2006)
- DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Rathmell, W.K., Kaufmann, W.K., Hurt, J.C., Byrd, L.L., Chu, G. Cancer Res. (1997)
- cDNA microarray analysis reveals chop-10 plays a key role in Sertoli cell injury induced by bisphenol A. Tabuchi, Y., Kondo, T. Biochem. Biophys. Res. Commun. (2003)