Gene Review:
E2f1 - E2F transcription factor 1
Mus musculus
Synonyms:
E2F-1, Transcription factor E2F1, mKIAA4009
- Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Baudino, T.A., Maclean, K.H., Brennan, J., Parganas, E., Yang, C., Aslanian, A., Lees, J.A., Sherr, C.J., Roussel, M.F., Cleveland, J.L. Mol. Cell (2003)
- Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis. Coulouarn, C., Gomez-Quiroz, L.E., Lee, J.S., Kaposi-Novak, P., Conner, E.A., Goldina, T.A., Onishchenko, G.E., Factor, V.M., Thorgeirsson, S.S. Hepatology (2006)
- Visualizing dynamic E2F-mediated repression in vivo. Agromayor, M., Wloga, E., Naglieri, B., Abrashkin, J., Verma, K., Yamasaki, L. Mol. Cell. Biol. (2006)
- Regulation of E2F4 mitogenic activity during terminal differentiation by its heterodimerization partners for nuclear translocation. Puri, P.L., Cimino, L., Fulco, M., Zimmerman, C., La Thangue, N.B., Giordano, A., Graessmann, A., Levrero, M. Cancer Res. (1998)
- Induction of p53 and melanoma cell death is reciprocal with down-regulation of E2F, cyclin D1 and pRB. Rieber, M., Strasberg-Rieber, M. Int. J. Cancer (1998)
- Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology. Shimizu, S., Khan, M.Z., Hippensteel, R.L., Parkar, A., Raghupathi, R., Meucci, O. Neurobiol. Dis. (2007)
- Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Yamasaki, L., Bronson, R., Williams, B.O., Dyson, N.J., Harlow, E., Jacks, T. Nat. Genet. (1998)
- Tumor induction and tissue atrophy in mice lacking E2F-1. Yamasaki, L., Jacks, T., Bronson, R., Goillot, E., Harlow, E., Dyson, N.J. Cell (1996)
- Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Krek, W., Xu, G., Livingston, D.M. Cell (1995)
- Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. Fajas, L., Annicotte, J.S., Miard, S., Sarruf, D., Watanabe, M., Auwerx, J. J. Clin. Invest. (2004)
- Adenovirus-mediated E2F-1 gene transfer sensitizes melanoma cells to apoptosis induced by topoisomerase II inhibitors. Dong, Y.B., Yang, H.L., Elliott, M.J., McMasters, K.M. Cancer Res. (2002)
- Cyclin-dependent kinase 2 and cyclin A interaction with E2F are targets for tyrosine induction of B16 melanoma terminal differentiation. Rieber, M., Rieber, M.S. Cell Growth Differ. (1994)
- Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy. Vara, D., Bicknell, K.A., Coxon, C.H., Brooks, G. J. Biol. Chem. (2003)
- Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo. Cloud, J.E., Rogers, C., Reza, T.L., Ziebold, U., Stone, J.R., Picard, M.H., Caron, A.M., Bronson, R.T., Lees, J.A. Mol. Cell. Biol. (2002)
- Molecular cloning, chromosomal mapping, and expression of the mouse p107 gene. Huppi, K., Siwarski, D., Mock, B.A., Dosik, J., Hamel, P.A. Mamm. Genome (1996)
- The E2F1-3 transcription factors are essential for cellular proliferation. Wu, L., Timmers, C., Maiti, B., Saavedra, H.I., Sang, L., Chong, G.T., Nuckolls, F., Giangrande, P., Wright, F.A., Field, S.J., Greenberg, M.E., Orkin, S., Nevins, J.R., Robinson, M.L., Leone, G. Nature (2001)
- The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Li, F.X., Zhu, J.W., Tessem, J.S., Beilke, J., Varella-Garcia, M., Jensen, J., Hogan, C.J., DeGregori, J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 Is Essential for G1/S Progression and Cellular Transformation. Sharma, N., Timmers, C., Trikha, P., Saavedra, H.I., Obery, A., Leone, G. J. Biol. Chem. (2006)
- Multiple members of the E2F transcription factor family are the products of oncogenes. Xu, G., Livingston, D.M., Krek, W. Proc. Natl. Acad. Sci. U.S.A. (1995)
- C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Timchenko, N.A., Wilde, M., Darlington, G.J. Mol. Cell. Biol. (1999)
- E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis. Rogoff, H.A., Pickering, M.T., Debatis, M.E., Jones, S., Kowalik, T.F. Mol. Cell. Biol. (2002)
- Induction and modulation of cerebellar granule neuron death by E2F-1. O'Hare, M.J., Hou, S.T., Morris, E.J., Cregan, S.P., Xu, Q., Slack, R.S., Park, D.S. J. Biol. Chem. (2000)
- Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells. Smith, R.A., Walker, T., Xie, X., Hou, S.T. Brain Res. Mol. Brain Res. (2003)
- Vanadate activated Akt and promoted S phase entry. Zhang, Z., Gao, N., He, H., Huang, C., Luo, J., Shi, X. Mol. Cell. Biochem. (2004)
- Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice. Gu, M., Singh, R.P., Dhanalakshmi, S., Mohan, S., Agarwal, R. Mol. Cancer Ther. (2006)
- E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair. Chen, D., Yu, Z., Zhu, Z., Lopez, C.D. J. Biol. Chem. (2008)
- Regulation of the PDK4 isozyme by the Rb-E2F1 complex. Hsieh, M.C., Das, D., Sambandam, N., Zhang, M.Q., Nahlé, Z. J. Biol. Chem. (2008)
- Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. Schwarz, J.K., Devoto, S.H., Smith, E.J., Chellappan, S.P., Jakoi, L., Nevins, J.R. EMBO J. (1993)
- Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Aslanian, A., Iaquinta, P.J., Verona, R., Lees, J.A. Genes Dev. (2004)
- Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1. Schulze, A., Zerfass, K., Spitkovsky, D., Henglein, B., Jansen-Dürr, P. Oncogene (1994)
- Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. Macleod, K.F., Hu, Y., Jacks, T. EMBO J. (1996)
- A role for nuclear phospholipase Cbeta 1 in cell cycle control. Faenza, I., Matteucci, A., Manzoli, L., Billi, A.M., Aluigi, M., Peruzzi, D., Vitale, M., Castorina, S., Suh, P.G., Cocco, L. J. Biol. Chem. (2000)
- Combinatorial gene control involving E2F and E Box family members. Giangrande, P.H., Zhu, W., Rempel, R.E., Laakso, N., Nevins, J.R. EMBO J. (2004)
- Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo. Jiang, S.X., Sheldrick, M., Desbois, A., Slinn, J., Hou, S.T. Mol. Cell. Biol. (2007)
- Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone mice. Panchanathan, R., Xin, H., Choubey, D. J. Immunol. (2008)
- E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Ziebold, U., Reza, T., Caron, A., Lees, J.A. Genes Dev. (2001)
- Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. Alevizopoulos, K., Vlach, J., Hennecke, S., Amati, B. EMBO J. (1997)
- Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Sreeramaneni, R., Chaudhry, A., McMahon, M., Sherr, C.J., Inoue, K. Mol. Cell. Biol. (2005)
- ARF is not required for apoptosis in Rb mutant mouse embryos. Tsai, K.Y., MacPherson, D., Rubinson, D.A., Crowley, D., Jacks, T. Curr. Biol. (2002)
- Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis. Hou, S.T., Xie, X., Baggley, A., Park, D.S., Chen, G., Walker, T. J. Biol. Chem. (2002)
- C/EBPbeta activates E2F-regulated genes in vivo via recruitment of the coactivator CREB-binding protein/P300. Wang, H., Larris, B., Peiris, T.H., Zhang, L., Le Lay, J., Gao, Y., Greenbaum, L.E. J. Biol. Chem. (2007)
- C/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence. Sebastian, T., Malik, R., Thomas, S., Sage, J., Johnson, P.F. EMBO J. (2005)
- Unique roles for E2F1 in the mouse lens in the absence of functional pRB proteins. Hyde, R.K., Griep, A.E. Invest. Ophthalmol. Vis. Sci. (2002)
- The paradox of E2F1: oncogene and tumor suppressor gene. Johnson, D.G. Mol. Carcinog. (2000)
- Differential expression of members of the E2F family of transcription factors in rodent testes. El-Darwish, K.S., Parvinen, M., Toppari, J. Reprod. Biol. Endocrinol. (2006)