Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

NOBOX - NOBOX oogenesis homeobox

Homo sapiens

Synonyms: Homeobox protein NOBOX, OG-2, OG2, OG2X, Og2x, ...

Zhao, X.X. et al., Choi, Y. et al., Huntriss, J. et al., Pangas, S.A. et al., Ballow, D.J. et al.

Huntriss, Hinkins, Picton,

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High impact information on NOBOX

These results suggest that NOBOX directly regulates the transcription of Pou5f1 and Gdf9 in oocytes during early folliculogenesis [1].
In addition, we found that promoter regions of mouse Pou5f1 and Gdf9 contain one (-426) and three NOBOX binding elements (-786, -967, and -1259), respectively [1].
Factor in the germline (Figla) and newborn ovary homeobox gene (Nobox) represent a growing number of oocyte-specific transcription factors that regulate genes unique to oocytes [2].
Nobox is a homeobox gene that is preferentially expressed in the oocytes and is essential for folliculogenesis and the regulation of oocyte-specific gene expression in the mouse [3].
Germ cell-specific transcription factors such as Figla and Nobox are critical in oogenesis, while Zfp148 and Taf4b are also critical in spermatogenesis [4].

Biological context of NOBOX

Our data suggest that mutations of the homeobox region of the NOBOX gene are uncommon in Japanese patients with POF [5].
No mutations in exons 2-6 of the NOBOX gene, including the homeobox region, could be identified in Japanese women with POF [5].

Other interactions of NOBOX

Mutational analysis of the homeobox region of the human NOBOX gene in Japanese women who exhibit premature ovarian failure [5].

Analytical, diagnostic and therapeutic context of NOBOX

Here, we present the first cDNA cloning and transcript expression analysis of the human NOBOX gene [3].

References

Characterization of NOBOX DNA Binding Specificity and Its Regulation of Gdf9 and Pou5f1 Promoters. Choi, Y., Rajkovic, A. J. Biol. Chem. (2006) [Pubmed]
Transcriptional regulation of early oogenesis: in search of masters. Pangas, S.A., Rajkovic, A. Hum. Reprod. Update (2006) [Pubmed]
cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. Huntriss, J., Hinkins, M., Picton, H.M. Mol. Hum. Reprod. (2006) [Pubmed]
Sohlh2 is a germ cell-specific bHLH transcription factor. Ballow, D.J., Xin, Y., Choi, Y., Pangas, S.A., Rajkovic, A. Gene Expr. Patterns (2006) [Pubmed]
Mutational analysis of the homeobox region of the human NOBOX gene in Japanese women who exhibit premature ovarian failure. Zhao, X.X., Suzumori, N., Yamaguchi, M., Suzumori, K. Fertil. Steril. (2005) [Pubmed]

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