Gene Review:
CPB1 - carboxypeptidase B1 (tissue)
Homo sapiens
Synonyms:
CPB, Carboxypeptidase B, PASP, PCPB, Pancreas-specific protein
- Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. Yamamoto, K.K., Pousette, A., Chow, P., Wilson, H., el Shami, S., French, C.K. J. Biol. Chem. (1992)
- Enhancement of fibrinolysis by EF6265 [(S)-7-amino-2-[[[(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxyphosphinoyl] methyl]heptanoic acid], a specific inhibitor of plasma carboxypeptidase B. Suzuki, K., Muto, Y., Fushihara, K., Kanemoto, K., Iida, H., Sato, E., Kikuchi, C., Matsushima, T., Kato, E., Nomoto, M., Yoshioka, S., Ishii, H. J. Pharmacol. Exp. Ther. (2004)
- Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis. Pascalis, H., Lavergne, A., Bourreau, E., Prévot-Linguet, G., Kariminia, A., Pradinaud, R., Rafati, S., Launois, P. Infect. Immun. (2003)
- A novel serum assay for pancreatic cellular damage. II. High tissue specificity of a pancreatic protein. Pousette, A., Fernstad, R., Sköldefors, H., Carlström, K. Pancreas (1988)
- The NOD mouse: a model of immune dysregulation. Anderson, M.S., Bluestone, J.A. Annu. Rev. Immunol. (2005)
- Evaluating neuroprotective agents for clinical anti-ischemic benefit using neurological and neuropsychological changes after cardiac surgery under cardiopulmonary bypass. Methodological strategies and results of a double-blind, placebo-controlled trial of GM1 ganglioside. Grieco, G., d'Hollosy, M., Culliford, A.T., Jonas, S. Stroke (1996)
- External validation of compliance to perfusion quality indicators. Dickinson, T., Riley, J., Zabetakis, P.M. Perfusion (2004)
- Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Ornitz, D.M., Palmiter, R.D., Hammer, R.E., Brinster, R.L., Swift, G.H., MacDonald, R.J. Nature (1985)
- Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Ijichi, H., Chytil, A., Gorska, A.E., Aakre, M.E., Fujitani, Y., Fujitani, S., Wright, C.V., Moses, H.L. Genes Dev. (2006)
- CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression. Cohen, L.E., Hashimoto, Y., Zanger, K., Wondisford, F., Radovick, S. J. Clin. Invest. (1999)
- Cloning and characterization of the novel gene for mast cell carboxypeptidase A. Reynolds, D.S., Gurley, D.S., Austen, K.F. J. Clin. Invest. (1992)
- Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant. Laughlin, M.J., McGaughey, D.S., Crews, J.R., Chao, N.J., Rizzieri, D., Ross, M., Gockerman, J., Cirrincione, C., Berry, D., Mills, L., Defusco, P., LeGrand, S., Peters, W.P., Vredenburgh, J.J. J. Clin. Oncol. (1998)
- Sulfonylurea treatment of type 2 diabetic patients does not reduce the vasodilator response to ischemia. Spallarossa, P., Schiavo, M., Rossettin, P., Cordone, S., Olivotti, L., Cordera, R., Brunelli, C. Diabetes Care (2001)
- alpha 1-Adrenergic responsiveness during coronary artery bypass surgery: effect of preoperative ejection fraction. Schwinn, D.A., McIntyre, R.W., Hawkins, E.D., Kates, R.A., Reves, J.G. Anesthesiology (1988)
- Glucose homeostasis. Comparison between hypothermic and normothermic cardiopulmonary bypass. Lehot, J.J., Piriz, H., Villard, J., Cohen, R., Guidollet, J. Chest (1992)
- Laboratory modalities for assessing hemostasis during cardiopulmonary bypass. Fekete, L.F., Bick, R.L. Semin. Thromb. Hemost. (1976)
- Isoforms of procarboxypeptidase B, (pancreas-specific protein, PASP) in human serum, pancreatic tissue and juice. Fernstad, R., Kylander, C., Tsai, L., Tydén, G., Pousette, A. Scand. J. Clin. Lab. Invest. Suppl. (1993)
- The intrinsic threshold of the fibrinolytic system is modulated by basic carboxypeptidases, but the magnitude of the antifibrinolytic effect of activated thrombin-activable fibrinolysis inhibitor is masked by its instability. Walker, J.B., Bajzar, L. J. Biol. Chem. (2004)
- Low degree of activation of circulating neutrophils determined by flow cytometry during cardiac surgery with cardiopulmonary bypass. Tárnok, A., Bocsi, J., Rössler, H., Schlykow, V., Schneider, P., Hambsch, J. Cytometry. (2001)
- The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences. Mottram, J.C., Frame, M.J., Brooks, D.R., Tetley, L., Hutchison, J.E., Souza, A.E., Coombs, G.H. J. Biol. Chem. (1997)
- The stage-regulated expression of Leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element. Brooks, D.R., Denise, H., Westrop, G.D., Coombs, G.H., Mottram, J.C. J. Biol. Chem. (2001)
- Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein. Valnickova, Z., Thogersen, I.B., Christensen, S., Chu, C.T., Pizzo, S.V., Enghild, J.J. J. Biol. Chem. (1996)
- Processing and trafficking of cysteine proteases in Leishmania mexicana. Brooks, D.R., Tetley, L., Coombs, G.H., Mottram, J.C. J. Cell. Sci. (2000)
- Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter. Smith, S.B., Watada, H., Scheel, D.W., Mrejen, C., German, M.S. J. Biol. Chem. (2000)
- Thrombin-activable fibrinolysis inhibitor attenuates (DD)E-mediated stimulation of plasminogen activation by reducing the affinity of (DD)E for tissue plasminogen activator. A potential mechanism for enhancing the fibrin specificity of tissue plasminogen activator. Stewart, R.J., Fredenburgh, J.C., Rischke, J.A., Bajzar, L., Weitz, J.I. J. Biol. Chem. (2000)
- Carboxypeptidase E. Fricker, L.D. Annu. Rev. Physiol. (1988)
- The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity. Sourdive, D.J., Transy, C., Garbay, S., Yaniv, M. Nucleic Acids Res. (1997)
- Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. Bajzar, L., Manuel, R., Nesheim, M.E. J. Biol. Chem. (1995)
- The clinical value of human pancreas-specific protein procarboxypeptidase B as an indicator of necrosis in acute pancreatitis: comparison to CRP and LDH. Rau, B., Cebulla, M., Uhl, W., Schoenberg, M.H., Beger, H.G. Pancreas (1998)