Gene Review:
CPE - carboxypeptidase E
Homo sapiens
Synonyms:
CPH, Carboxypeptidase E, Carboxypeptidase H, Enkephalin convertase, Prohormone-processing carboxypeptidase
- Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous and visceral fat of obese subjects. Ramis, J.M., Franssen-van Hal, N.L., Kramer, E., Llado, I., Bouillaud, F., Palou, A., Keijer, J. Cell. Mol. Life Sci. (2002)
- Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary. Fan, X., Olson, S.J., Blevins, L.S., Allen, G.S., Johnson, M.D. J. Histochem. Cytochem. (2002)
- Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. He, P., Varticovski, L., Bowman, E.D., Fukuoka, J., Welsh, J.A., Miura, K., Jen, J., Gabrielson, E., Brambilla, E., Travis, W.D., Harris, C.C. Hum. Pathol. (2004)
- Identification of a novel prohormone sorting signal-binding site on carboxypeptidase E, a regulated secretory pathway-sorting receptor. Zhang, C.F., Snell, C.R., Loh, Y.P. Mol. Endocrinol. (1999)
- Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. Manser, E., Fernandez, D., Loo, L., Goh, P.Y., Monfries, C., Hall, C., Lim, L. Biochem. J. (1990)
- Adapting CPE to an Asian life style. Keidel, K.W. Journal of pastoral care. (1975)
- Racial and gender myths as key factors in pastoral supervision. Robinson, E., Needham, M.A. Journal of pastoral care. (1991)
- Personality traits in leadership behavior. Kornør, H., Nordvik, H. Scandinavian journal of psychology. (2004)
- Group supervision versus group psychotherapy: similarities and differences for clinical pastoral education. Bogia, B.P. Journal of pastoral care. (1987)
- The HealthCare Chaplaincy, Inc., New York, New York. Handzo, G.F., Smith, W.J., Twiname, J., Twiname, C., Weiss, W.M. Journal of health care chaplaincy. (1999)
- Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Jackson, R.S., Creemers, J.W., Ohagi, S., Raffin-Sanson, M.L., Sanders, L., Montague, C.T., Hutton, J.C., O'Rahilly, S. Nat. Genet. (1997)
- Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cool, D.R., Normant, E., Shen, F., Chen, H.C., Pannell, L., Zhang, Y., Loh, Y.P. Cell (1997)
- Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Naggert, J.K., Fricker, L.D., Varlamov, O., Nishina, P.M., Rouille, Y., Steiner, D.F., Carroll, R.J., Paigen, B.J., Leiter, E.H. Nat. Genet. (1995)
- Carboxypeptidase E. Fricker, L.D. Annu. Rev. Physiol. (1988)
- Processing and secretion of human carboxypeptidase E by C6 glioma cells. Manser, E., Fernandez, D., Lim, L. Biochem. J. (1991)
- Cord blood leptin levels: relationship to body weight, body mass index, sex and insulin and cortisol levels of maternal-newborn pairs at delivery. Kirel, B., Tekin, N., Tekin, B., Kiliç, F.S., Doğruel, N., Aydoğdu, S.D. Journal of pediatric endocrinology & metabolism : JPEM. (2000)
- Antiviral and antiproliferative activities of human leukocyte interferon potentiated by cimetidine in vitro. Hirai, N., Hill, N.O., Motoo, Y., Osther, K. J. Interferon Res. (1985)
- Relation of the hepatitis B virus carrier state to hepatocellular carcinoma. Popper, H., Shafritz, D.A., Hoofnagle, J.H. Hepatology (1987)
- Identification of zymogen and mature forms of human carboxypeptidase H. A processing enzyme for the synthesis of peptide hormones. Hook, V.Y., Affolter, H.U. FEBS Lett. (1988)
- Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2. Lei, Y., Xin, X., Morgan, D., Pintar, J.E., Fricker, L.D. DNA Cell Biol. (1999)
- Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. Utsunomiya, N., Ohagi, S., Sanke, T., Tatsuta, H., Hanabusa, T., Nanjo, K. Diabetologia (1998)
- Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity. Chen, H., Jawahar, S., Qian, Y., Duong, Q., Chan, G., Parker, A., Meyer, J.M., Moore, K.J., Chayen, S., Gross, D.J., Glaser, B., Permutt, M.A., Fricker, L.D. Hum. Mutat. (2001)
- Immunohistochemical localization of carboxypeptidases E and D in the human placenta and umbilical cord. Reznik, S.E., Salafia, C.M., Lage, J.M., Fricker, L.D. J. Histochem. Cytochem. (1998)
- Immunohistochemical localization and comparison of carboxypeptidases D, E, and Z, alpha-MSH, ACTH, and MIB-1 between human anterior and corticotroph cell "basophil invasion" of the posterior pituitary. Fan, X., Olson, S.J., Johnson, M.D. J. Histochem. Cytochem. (2001)
- Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid rafts. Zhang, C.F., Dhanvantari, S., Lou, H., Loh, Y.P. Biochem. J. (2003)
- Identification of gp17 glycoprotein and characterization of prostatic acid phosphatase (PAP) and carboxypeptidase E (CPE) fragments in a human seminal plasma fraction interacting with concanavalin A. Marquínez, A.C., Andreetta, A.M., González, N., Wolfenstein-Todel, C., Scacciati de Cerezo, J.M. J. Protein Chem. (2003)
- High affinity vasoactive intestinal peptide receptors on fetal human nonpigmented ciliary epithelial cells. Crook, R.B., Lui, G.M., Alvarado, J.A., Fauss, D.J., Polansky, J.R. Curr. Eye Res. (1994)
- Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules. Fricker, L.D., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1982)
- The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans. Guest, P.C., Arden, S.D., Rutherford, N.G., Hutton, J.C. Mol. Cell. Endocrinol. (1995)
- Recycling of Raft-associated prohormone sorting receptor carboxypeptidase E requires interaction with ARF6. Arnaoutova, I., Jackson, C.L., Al-Awar, O.S., Donaldson, J.G., Loh, Y.P. Mol. Biol. Cell (2003)
- New insights into the cytotoxic mechanisms of Clostridium perfringens enterotoxin. McClane, B.A., Chakrabarti, G. Anaerobe (2004)
- Cloning of candidate autoantigen carboxypeptidase H from a human islet library: sequence identity with human brain CPH. Alcalde, L., Tonacchera, M., Costagliola, S., Jaraquemada, D., Pujol-Borrell, R., Ludgate, M. J. Autoimmun. (1996)
- Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells. Zhang, T., Chen, X., Qu, L., Wu, J., Cui, R., Zhao, Y. Bioorg. Med. Chem. (2004)
- Gene expression profiling in human insulinoma tissue: genes involved in the insulin secretion pathway and cloning of novel full-length cDNAs. Wang, X.C., Xu, S.Y., Wu, X.Y., Song, H.D., Mao, Y.F., Fan, H.Y., Yu, F., Mou, B., Gu, Y.Y., Xu, L.Q., Zhou, X.O., Chen, Z., Chen, J.L., Hu, R.M. Endocr. Relat. Cancer (2004)
- Identification of a neuropeptide and neuropeptide-processing enzymes in aqueous humor confers neuroendocrine features to the human ocular ciliary epithelium. Ortego, J., Escribano, J., Crabb, J., Coca-Prados, M. J. Neurochem. (1996)
- Molecular cloning of Aplysia neuronal cDNAs that encode carboxypeptidases related to mammalian prohormone processing enzymes. Fan, X., Nagle, G.T. DNA Cell Biol. (1996)
- Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A. Normant, E., Loh, Y.P. Endocrinology (1998)
- Early detection of human cytomegalovirus infection after kidney transplantation by nucleic acid sequence-based amplification. Blok, M.J., Christiaans, M.H., Goossens, V.J., van Hooff, J.P., Sillekens, P., Middeldorp, J.M., Bruggeman, C.A. Transplantation (1999)