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Gene Review

Egf  -  epidermal growth factor

Mus musculus

Synonyms: AI790464, EGF, Pro-epidermal growth factor
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Disease relevance of Egf


Psychiatry related information on Egf

  • Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling [6].
  • To determine if the lack of EGF may be a decisive factor in the initiation and/or growth of collecting duct cysts, we administered exogenous EGF (1 microgram/g body wt subcutaneously) daily for Postnatal Days 3-9 (a critical period for collecting duct maturation) to C57BL/6J-cpk mice [7].
  • The latency period for the epidermal growth factor induction of the hyperpolarizing potential was approximately 3 hr [8].
  • Because the decrease in liver glycogen and the increase in plasma epidermal growth factor (EGF) were also smaller in restraint than in the tape-immobilization model of emotional stress, we conclude that the former is a less intense stressor than the latter [9].

High impact information on Egf


Chemical compound and disease context of Egf


Biological context of Egf


Anatomical context of Egf


Associations of Egf with chemical compounds


Physical interactions of Egf


Enzymatic interactions of Egf


Co-localisations of Egf


Regulatory relationships of Egf


Other interactions of Egf


Analytical, diagnostic and therapeutic context of Egf


  1. Epidermal growth factor receptor occupancy inhibits vaccinia virus infection. Eppstein, D.A., Marsh, Y.V., Schreiber, A.B., Newman, S.R., Todaro, G.J., Nestor, J.J. Nature (1985) [Pubmed]
  2. Abrogation of cisplatin-induced programmed cell death in human breast cancer cells by epidermal growth factor antisense RNA. Dixit, M., Yang, J.L., Poirier, M.C., Price, J.O., Andrews, P.A., Arteaga, C.L. J. Natl. Cancer Inst. (1997) [Pubmed]
  3. Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. McCole, D.F., Rogler, G., Varki, N., Barrett, K.E. Gastroenterology (2005) [Pubmed]
  4. Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells. Wagner, M., Weber, C.K., Bressau, F., Greten, F.R., Stagge, V., Ebert, M., Leach, S.D., Adler, G., Schmid, R.M. Gastroenterology (2002) [Pubmed]
  5. Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Fichera, A., Little, N., Jagadeeswaran, S., Dougherty, U., Sehdev, A., Mustafi, R., Cerda, S., Yuan, W., Khare, S., Tretiakova, M., Gong, C., Tallerico, M., Cohen, G., Joseph, L., Hart, J., Turner, J.R., Bissonnette, M. Cancer Res. (2007) [Pubmed]
  6. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Kramer, A., Yang, F.C., Snodgrass, P., Li, X., Scammell, T.E., Davis, F.C., Weitz, C.J. Science (2001) [Pubmed]
  7. Epidermal growth factor ameliorates autosomal recessive polycystic kidney disease in mice. Gattone, V.H., Lowden, D.A., Cowley, B.D. Dev. Biol. (1995) [Pubmed]
  8. Induction of distinct types of spontaneous electrical activities in mammary epithelial cells by epidermal growth factor and insulin. Enomoto, K., Cossu, M.F., Edwards, C., Oka, T. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  9. Acute stress-induced tissue injury in mice: differences between emotional and social stress. Sánchez, O., Arnau, A., Pareja, M., Poch, E., Ramírez, I., Soley, M. Cell Stress Chaperones (2002) [Pubmed]
  10. EGF receptor activation: push comes to shove. Hubbard, S.R. Cell (2006) [Pubmed]
  11. Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Wu, W.J., Tu, S., Cerione, R.A. Cell (2003) [Pubmed]
  12. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Smas, C.M., Sul, H.S. Cell (1993) [Pubmed]
  13. Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase-mediated leukotriene C4 production. Peppelenbosch, M.P., Tertoolen, L.G., den Hertog, J., de Laat, S.W. Cell (1992) [Pubmed]
  14. Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha. Troyer, K.L., Luetteke, N.C., Saxon, M.L., Qiu, T.H., Xian, C.J., Lee, D.C. Gastroenterology (2001) [Pubmed]
  15. Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway? Budnik, L.T., Brunswig-Spickenheier, B., Mukhopadhyay, A.K. Mol. Endocrinol. (2003) [Pubmed]
  16. EGF-related growth factors in the pathogenesis of murine ARPKD. MacRae Dell, K., Nemo, R., Sweeney, W.E., Avner, E.D. Kidney Int. (2004) [Pubmed]
  17. Transforming growth factor-alpha deficiency reduces pulmonary fibrosis in transgenic mice. Madtes, D.K., Elston, A.L., Hackman, R.C., Dunn, A.R., Clark, J.G. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  18. Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Younes, M.N., Park, Y.W., Yazici, Y.D., Gu, M., Santillan, A.A., Nong, X., Kim, S., Jasser, S.A., El-Naggar, A.K., Myers, J.N. Mol. Cancer Ther. (2006) [Pubmed]
  19. Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf. Milatovich, A., Travis, A., Grosschedl, R., Francke, U. Genomics (1991) [Pubmed]
  20. Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor. Yamashita, H., Oesterle, E.C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  21. Cell surface fibroblast growth factor and epidermal growth factor receptors are permanently lost during skeletal muscle terminal differentiation in culture. Olwin, B.B., Hauschka, S.D. J. Cell Biol. (1988) [Pubmed]
  22. Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis. Snedeker, S.M., Brown, C.F., DiAugustine, R.P. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  23. Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. Ruff-Jamison, S., Chen, K., Cohen, S. Science (1993) [Pubmed]
  24. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. Baselga, J., Norton, L., Masui, H., Pandiella, A., Coplan, K., Miller, W.H., Mendelsohn, J. J. Natl. Cancer Inst. (1993) [Pubmed]
  25. Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor. Curtis, S.W., Washburn, T., Sewall, C., DiAugustine, R., Lindzey, J., Couse, J.F., Korach, K.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  26. Neuropeptide-induced transactivation of a neuronal epidermal growth factor receptor is mediated by metalloprotease-dependent formation of heparin-binding epidermal growth factor. Shah, B.H., Farshori, M.P., Catt, K.J. J. Biol. Chem. (2004) [Pubmed]
  27. Intrapituitary regulatory system of mammotrophs in the mouse. Takahashi, S., Sharma, S., Oomizu, S., Honda, J., Takeuchi, S. Arch. Physiol. Biochem. (2002) [Pubmed]
  28. Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells. Anzano, M.A., Roberts, A.B., Meyers, C.A., Komoriya, A., Lamb, L.C., Smith, J.M., Sporn, M.B. Cancer Res. (1982) [Pubmed]
  29. Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway. Glading, A., Chang, P., Lauffenburger, D.A., Wells, A. J. Biol. Chem. (2000) [Pubmed]
  30. Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver. Ruff-Jamison, S., Zhong, Z., Wen, Z., Chen, K., Darnell, J.E., Cohen, S. J. Biol. Chem. (1994) [Pubmed]
  31. Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor. Mothe, I., Ballotti, R., Tartare, S., Kowalski-Chauvel, A., Van Obberghen, E. Mol. Biol. Cell (1993) [Pubmed]
  32. A 120 kDa nuclear phospholipase Cgamma1 protein fragment is stimulated in vivo by EGF signal phosphorylating nuclear membrane EGFR. Klein, C., Gensburger, C., Freyermuth, S., Nair, B.C., Labourdette, G., Malviya, A.N. Biochemistry (2004) [Pubmed]
  33. The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment. Meisenhelder, J., Hunter, T. Mol. Cell. Biol. (1992) [Pubmed]
  34. Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factor. Walker, F., Burgess, A.W. J. Biol. Chem. (1991) [Pubmed]
  35. A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein. Trentin, G.A., Yin, X., Tahir, S., Lhotak, S., Farhang-Fallah, J., Li, Y., Rozakis-Adcock, M. J. Biol. Chem. (2001) [Pubmed]
  36. Epidermal growth factor or transforming growth factor alpha is required for kidney tubulogenesis in matrigel cultures in serum-free medium. Taub, M., Wang, Y., Szczesny, T.M., Kleinman, H.K. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  37. Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells. Huang, C., Ma, W.Y., Young, M.R., Colburn, N., Dong, Z. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  38. Fibroblast growth factor 2 (FGF-2) promotes acquisition of epidermal growth factor (EGF) responsiveness in mouse striatal precursor cells: identification of neural precursors responding to both EGF and FGF-2. Ciccolini, F., Svendsen, C.N. J. Neurosci. (1998) [Pubmed]
  39. PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib. Ueda, S., Basaki, Y., Yoshie, M., Ogawa, K., Sakisaka, S., Kuwano, M., Ono, M. Cancer Res. (2006) [Pubmed]
  40. Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities. Akamatsu, M., Aota, S., Suwa, A., Ueda, K., Amachi, T., Yamada, K.M., Akiyama, S.K., Kioka, N. J. Biol. Chem. (1999) [Pubmed]
  41. Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors. Paria, B.C., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  42. Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity. Kimura, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  43. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Lee, D., Pearsall, R.S., Das, S., Dey, S.K., Godfrey, V.L., Threadgill, D.W. Mol. Cell. Biol. (2004) [Pubmed]
  44. Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Suen, K.L., Bustelo, X.R., Pawson, T., Barbacid, M. Mol. Cell. Biol. (1993) [Pubmed]
  45. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. Reynolds, B.A., Tetzlaff, W., Weiss, S. J. Neurosci. (1992) [Pubmed]
  46. Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands. Dlugosz, A.A., Cheng, C., Williams, E.K., Darwiche, N., Dempsey, P.J., Mann, B., Dunn, A.R., Coffey, R.J., Yuspa, S.H. Cancer Res. (1995) [Pubmed]
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