Gene Review:
Fap - fibroblast activation protein
Mus musculus
Synonyms:
Dipeptidyl peptidase FAP, FAPalpha, Fibroblast activation protein alpha, Gelatine degradation protease FAP, Integral membrane serine protease, ...
- Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha). Gilmore, B.F., Lynas, J.F., Scott, C.J., McGoohan, C., Martin, L., Walker, B. Biochem. Biophys. Res. Commun. (2006)
- FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor. Ramirez-Montagut, T., Blachere, N.E., Sviderskaya, E.V., Bennett, D.C., Rettig, W.J., Garin-Chesa, P., Houghton, A.N. Oncogene (2004)
- Pathologic interaction between megakaryocytes and polymorphonuclear leukocytes in myelofibrosis. Schmitt, A., Jouault, H., Guichard, J., Wendling, F., Drouin, A., Cramer, E.M. Blood (2000)
- Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer. Huang, Y., Wang, S., Kelly, T. Cancer Res. (2004)
- Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts. Jakubzick, C., Choi, E.S., Kunkel, S.L., Joshi, B.H., Puri, R.K., Hogaboam, C.M. Am. J. Pathol. (2003)
- Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. Loeffler, M., Krüger, J.A., Niethammer, A.G., Reisfeld, R.A. J. Clin. Invest. (2006)
- Targeted disruption of mouse fibroblast activation protein. Niedermeyer, J., Kriz, M., Hilberg, F., Garin-Chesa, P., Bamberger, U., Lenter, M.C., Park, J., Viertel, B., Püschner, H., Mauz, M., Rettig, W.J., Schnapp, A. Mol. Cell. Biol. (2000)
- PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Adams, S., Miller, G.T., Jesson, M.I., Watanabe, T., Jones, B., Wallner, B.P. Cancer Res. (2004)
- Clinical implications of fibroblast activation protein in patients with colon cancer. Henry, L.R., Lee, H.O., Lee, J.S., Klein-Szanto, A., Watts, P., Ross, E.A., Chen, W.T., Cheng, J.D. Clin. Cancer Res. (2007)
- Mouse fibroblast-activation protein--conserved Fap gene organization and biochemical function as a serine protease. Niedermeyer, J., Enenkel, B., Park, J.E., Lenter, M., Rettig, W.J., Damm, K., Schnapp, A. Eur. J. Biochem. (1998)
- Expression of the fibroblast activation protein during mouse embryo development. Niedermeyer, J., Garin-Chesa, P., Kriz, M., Hilberg, F., Mueller, E., Bamberger, U., Rettig, W.J., Schnapp, A. Int. J. Dev. Biol. (2001)
- Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy. Kelly, T. Drug Resist. Updat. (2005)
- Production of a fibroblast-stimulating factor by Schistosoma mansoni antigen-reactive T cell clones. Lammie, P.J., Michael, A.I., Linette, G.P., Phillips, S.M. J. Immunol. (1986)
- Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. Holgate, S.T., Peters-Golden, M., Panettieri, R.A., Henderson, W.R. J. Allergy Clin. Immunol. (2003)
- Cellular and molecular mechanisms of bleomycin-induced murine scleroderma: current update and future perspective. Yamamoto, T., Nishioka, K. Exp. Dermatol. (2005)
- cDNA cloning and expression of secreted Xenopus laevis dipeptidyl aminopeptidase IV. Vlasak, R., Vilas, U., Strobl, B., Kreil, G. Eur. J. Biochem. (1997)
- Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity. Ortega, A., Rámila, D., Ardura, J.A., Esteban, V., Ruiz-Ortega, M., Barat, A., Gazapo, R., Bosch, R.J., Esbrit, P. J. Am. Soc. Nephrol. (2006)
- Generation of a FasL-based proapoptotic fusion protein devoid of systemic toxicity due to cell-surface antigen-restricted Activation. Samel, D., Muller, D., Gerspach, J., Assohou-Luty, C., Sass, G., Tiegs, G., Pfizenmaier, K., Wajant, H. J. Biol. Chem. (2003)
- Tryptase 4, a new member of the chromosome 17 family of mouse serine proteases. Wong, G.W., Li, L., Madhusudhan, M.S., Krilis, S.A., Gurish, M.F., Rothenberg, M.E., Sali, A., Stevens, R.L. J. Biol. Chem. (2001)
- Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing. Saika, S., Ikeda, K., Yamanaka, O., Flanders, K.C., Okada, Y., Miyamoto, T., Kitano, A., Ooshima, A., Nakajima, Y., Ohnishi, Y., Kao, W.W. Am. J. Pathol. (2006)
- Mouse fibroblast activation protein: molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers. Niedermeyer, J., Scanlan, M.J., Garin-Chesa, P., Daiber, C., Fiebig, H.H., Old, L.J., Rettig, W.J., Schnapp, A. Int. J. Cancer (1997)
- Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth. Cheng, J.D., Valianou, M., Canutescu, A.A., Jaffe, E.K., Lee, H.O., Wang, H., Lai, J.H., Bachovchin, W.W., Weiner, L.M. Mol. Cancer Ther. (2005)
- Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts. Lee, J., Fassnacht, M., Nair, S., Boczkowski, D., Gilboa, E. Cancer Res. (2005)