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MIB2  -  mindbomb E3 ubiquitin protein ligase 2

Homo sapiens

 
 
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Disease relevance of MIB2

  • Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restored skeletrophin expression in cultured Mewo melanoma cells [1].
  • In malignant plasma cells from 23 of 40 multiple myeloma specimens, strong skeletrophin expression was observed, especially from patients with osteolytic bone lesions [2].
  • Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations [3].
  • Isolation of a cDNA encoding a novel zinc-finger protein from neuroblastoma x glioma NG108-15 cells [4].
  • Cloning and characterization of a novel zinc finger protein (MDZF) that is associated with monocytic differentiation of acute promyelocytic leukemia cells [5].
 

High impact information on MIB2

 

Biological context of MIB2

 

Anatomical context of MIB2

  • Northern blot analysis revealed that the 3.2-kb skeletrophin mRNA was expressed in normal skeletal muscle, and to a lesser extent in heart, brain, and kidney [1].
  • The A20 gene product is a novel zinc finger protein originally described as a tumor necrosis factor alpha (TNF)-inducible early response gene in human umbilical vein endothelial cells (HUVEC) [10].
  • We also found that skeletrophin downregulated transcription of the Met oncogene, which encodes the hepatocyte growth factor receptor and plays a role in the determination of the invasive phenotype of many malignant tumors [11].
  • GLP-1: A novel zinc finger protein required in somatic cells of the gonad for germ cell development [12].
  • Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells [13].
 

Associations of MIB2 with chemical compounds

 

Other interactions of MIB2

 

Analytical, diagnostic and therapeutic context of MIB2

References

  1. Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. Takeuchi, T., Heng, H.H., Ye, C.J., Liang, S.B., Iwata, J., Sonobe, H., Ohtsuki, Y. Am. J. Pathol. (2003) [Pubmed]
  2. Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. Takeuchi, T., Adachi, Y., Ohtsuki, Y. Am. J. Pathol. (2005) [Pubmed]
  3. Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Kas, K., Voz, M.L., Röijer, E., Aström, A.K., Meyen, E., Stenman, G., Van de Ven, W.J. Nat. Genet. (1997) [Pubmed]
  4. Isolation of a cDNA encoding a novel zinc-finger protein from neuroblastoma x glioma NG108-15 cells. Wick, M.J., Ann, D.K., Lee, N.M., Loh, H.H. Gene (1995) [Pubmed]
  5. Cloning and characterization of a novel zinc finger protein (MDZF) that is associated with monocytic differentiation of acute promyelocytic leukemia cells. Yuan, Z., Huang, X., Zhang, W., Zhang, M., Wan, T., Cao, X. J. Cancer Res. Clin. Oncol. (2001) [Pubmed]
  6. The POZ domain: a conserved protein-protein interaction motif. Bardwell, V.J., Treisman, R. Genes Dev. (1994) [Pubmed]
  7. Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. Benanti, J.A., Williams, D.K., Robinson, K.L., Ozer, H.L., Galloway, D.A. Mol. Cell. Biol. (2002) [Pubmed]
  8. Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. Takeuchi, T., Adachi, Y., Ohtsuki, Y. DNA Cell Biol. (2005) [Pubmed]
  9. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. Sarma, V., Lin, Z., Clark, L., Rust, B.M., Tewari, M., Noelle, R.J., Dixit, V.M. J. Biol. Chem. (1995) [Pubmed]
  10. A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism. Cooper, J.T., Stroka, D.M., Brostjan, C., Palmetshofer, A., Bach, F.H., Ferran, C. J. Biol. Chem. (1996) [Pubmed]
  11. A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. Takeuchi, T., Adachi, Y., Sonobe, H., Furihata, M., Ohtsuki, Y. Oncogene (2006) [Pubmed]
  12. GLP-1: A novel zinc finger protein required in somatic cells of the gonad for germ cell development. Li, S., Lu, M.M., Zhou, D., Hammes, S.R., Morrisey, E.E. Dev. Biol. (2007) [Pubmed]
  13. Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells. Peng, H., Du, Z.W., Zhang, J.W. Leukemia (2006) [Pubmed]
  14. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. Cattoretti, G., Becker, M.H., Key, G., Duchrow, M., Schlüter, C., Galle, J., Gerdes, J. J. Pathol. (1992) [Pubmed]
  15. Cloning and characterization of a novel zinc finger protein (rZFP96) in the rat corpus luteum. Lareu, R.R., Lacher, M.D., Friis, R.R., Dharmarajan, A.M. Biochim. Biophys. Acta (2005) [Pubmed]
  16. Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445. Luo, K., Yuan, J., Shan, Y., Li, J., Xu, M., Cui, Y., Tang, W., Wan, B., Zhang, N., Wu, Y., Yu, L. Gene (2006) [Pubmed]
  17. Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis. Ishizuka, M., Ohshima, H., Tamura, N., Nakada, T., Inoue, A., Hirose, S., Hagiwara, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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