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Gene Review

CSPG4  -  chondroitin sulfate proteoglycan 4

Homo sapiens

Synonyms: Chondroitin sulfate proteoglycan 4, Chondroitin sulfate proteoglycan NG2, HMW-MAA, MCSP, MCSPG, ...
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Disease relevance of CSPG4


High impact information on CSPG4


Chemical compound and disease context of CSPG4


Biological context of CSPG4


Anatomical context of CSPG4


Associations of CSPG4 with chemical compounds


Regulatory relationships of CSPG4


Other interactions of CSPG4


Analytical, diagnostic and therapeutic context of CSPG4


  1. Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. Yang, J., Price, M.A., Neudauer, C.L., Wilson, C., Ferrone, S., Xia, H., Iida, J., Simpson, M.A., McCarthy, J.B. J. Cell Biol. (2004) [Pubmed]
  2. Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. Pluschke, G., Vanek, M., Evans, A., Dittmar, T., Schmid, P., Itin, P., Filardo, E.J., Reisfeld, R.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors. Shoshan, Y., Nishiyama, A., Chang, A., Mörk, S., Barnett, G.H., Cowell, J.K., Trapp, B.D., Staugaitis, S.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Identification of the human melanoma-associated chondroitin sulfate proteoglycan antigen epitope recognized by the antitumor monoclonal antibody 763.74 from a peptide phage library. Geiser, M., Schultz, D., Le Cardinal, A., Voshol, H., García-Echeverría, C. Cancer Res. (1999) [Pubmed]
  5. NG2 colocalizes with axons and is expressed by a mixed cell population in spinal cord lesions. McTigue, D.M., Tripathi, R., Wei, P. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  6. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Eisenmann, K.M., McCarthy, J.B., Simpson, M.A., Keely, P.J., Guan, J.L., Tachibana, K., Lim, L., Manser, E., Furcht, L.T., Iida, J. Nat. Cell Biol. (1999) [Pubmed]
  7. Spreading and focal contact formation of human melanoma cells in response to the stimulation of both melanoma-associated proteoglycan (NG2) and alpha 4 beta 1 integrin. Iida, J., Meijne, A.M., Spiro, R.C., Roos, E., Furcht, L.T., McCarthy, J.B. Cancer Res. (1995) [Pubmed]
  8. A factor produced by feeder cells which inhibits embryonal carcinoma cell differentiation. Characterization and partial purification. Koopman, P., Cotton, R.G. Exp. Cell Res. (1984) [Pubmed]
  9. Characterization of retinaldehyde dehydrogenase-2 induction in NG2-positive glia after spinal cord contusion injury. Kern, J., Schrage, K., Koopmans, G.C., Joosten, E.A., McCaffery, P., Mey, J. Int. J. Dev. Neurosci. (2007) [Pubmed]
  10. Development of NG2 neural progenitor cells requires Olig gene function. Ligon, K.L., Kesari, S., Kitada, M., Sun, T., Arnett, H.A., Alberta, J.A., Anderson, D.J., Stiles, C.D., Rowitch, D.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  11. Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. Iida, J., Pei, D., Kang, T., Simpson, M.A., Herlyn, M., Furcht, L.T., McCarthy, J.B. J. Biol. Chem. (2001) [Pubmed]
  12. Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. Makagiansar, I.T., Williams, S., Dahlin-Huppe, K., Fukushi, J., Mustelin, T., Stallcup, W.B. J. Biol. Chem. (2004) [Pubmed]
  13. Inhibition of post-translational modification and surface expression of a melanoma-associated chondroitin sulfate proteoglycan by diethylcarbamazine or ammonium chloride. Spiro, R.C., Parsons, W.G., Perry, S.K., Caulfield, J.P., Hein, A., Reisfeld, R.A., Harper, J.R., Austen, K.F., Stevens, R.L. J. Biol. Chem. (1986) [Pubmed]
  14. Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas. Majumdar, M., Vuori, K., Stallcup, W.B. Cell. Signal. (2003) [Pubmed]
  15. Erythropoietin-mediated preservation of the white matter in rat spinal cord injury. Vitellaro-Zuccarello, L., Mazzetti, S., Madaschi, L., Bosisio, P., Gorio, A., De Biasi, S. Neuroscience (2007) [Pubmed]
  16. The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. Barritt, D.S., Pearn, M.T., Zisch, A.H., Lee, S.S., Javier, R.T., Pasquale, E.B., Stallcup, W.B. J. Cell. Biochem. (2000) [Pubmed]
  17. Gene expression profiles of 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU)-resistant C6 rat glioma cells. Nakagawa, T., Kubota, T., Ido, K., Sakuma, T., Matsuda, K. J. Neurooncol. (2006) [Pubmed]
  18. Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. Legg, J., Jensen, U.B., Broad, S., Leigh, I., Watt, F.M. Development (2003) [Pubmed]
  19. Altered expression of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency. Petrini, S., Tessa, A., Stallcup, W.B., Sabatelli, P., Pescatori, M., Giusti, B., Carrozzo, R., Verardo, M., Bergamin, N., Columbaro, M., Bernardini, C., Merlini, L., Pepe, G., Bonaldo, P., Bertini, E. Mol. Cell. Neurosci. (2005) [Pubmed]
  20. A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. Staub, E., Hinzmann, B., Rosenthal, A. FEBS Lett. (2002) [Pubmed]
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