Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: Nmur1 - neuromedin U receptor 1

Mus musculus

Synonyms: FM-3, Gpr66, G-protein coupled receptor 66, G-protein coupled receptor FM-3, Neuromedin U receptor 1, Neuromedin-U receptor 1, NMU1R, NmU-R, NMU-R1

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Moriyama, M., Moriyama, M., Prendergast, C.E., Hanada, T.

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High impact information on Nmur1

These data indicate that NMU promotes mast cell-mediated inflammation; therefore, NMU receptor antagonists could be a novel target for pharmacological inhibition of mast cell-mediated inflammatory diseases [1].
Whereas NMU-R2 localizes predominantly to nerve cells, NMU-R1 is expressed in peripheral tissues including lymphocytes and monocytes, suggesting a role of NMU in immunoregulation [1].
These data suggest that LPS-induced IL-6 expression is partly dependent on autocrine/paracrine activation of the NMU-NMU-R1 signals in macrophages [2].
One NMU receptor, NMU2R, is abundantly expressed in the hypothalamic paraventricular nucleus, where corticotrophin-releasing hormone (CRH) is synthesized [3].

Anatomical context of Nmur1

Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice [4].
NMU-R1 was highly expressed in primary mast cells, and NMU induced Ca(2+) mobilization and degranulation in peritoneal mast cells [1].

Regulatory relationships of Nmur1

However, the NMU receptor NMU-R1 has been shown to be expressed in immune cells and NMU promotes mast cell-dependent inflammation [2].

References

The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells. Moriyama, M., Sato, T., Inoue, H., Fukuyama, S., Teranishi, H., Kangawa, K., Kano, T., Yoshimura, A., Kojima, M. J. Exp. Med. (2005)
The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock. Moriyama, M., Matsukawa, A., Kudoh, S., Takahashi, T., Sato, T., Kano, T., Yoshimura, A., Kojima, M. Biochem. Biophys. Res. Commun. (2006)
Central actions of neuromedin U via corticotropin-releasing hormone. Hanada, T., Date, Y., Shimbara, T., Sakihara, S., Murakami, N., Hayashi, Y., Kanai, Y., Suda, T., Kangawa, K., Nakazato, M. Biochem. Biophys. Res. Commun. (2003)
Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice. Prendergast, C.E., Morton, M.F., Figueroa, K.W., Wu, X., Shankley, N.P. Br. J. Pharmacol. (2006)

Gene: Nmur1 - neuromedin U receptor 1

Mus musculus

High impact information on Nmur1

Anatomical context of Nmur1

Regulatory relationships of Nmur1

References

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