Gene Review:
Hspa5 - heat shock protein 5
Mus musculus
Synonyms:
78 kDa glucose-regulated protein, 78kDa, AL022860, AU019543, BiP, ...
- The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction. Misra, U.K., Gonzalez-Gronow, M., Gawdi, G., Hart, J.P., Johnson, C.E., Pizzo, S.V. J. Biol. Chem. (2002)
- Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Thuerauf, D.J., Marcinko, M., Gude, N., Rubio, M., Sussman, M.A., Glembotski, C.C. Circ. Res. (2006)
- Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78. Bhattacharjee, G., Ahamed, J., Pedersen, B., El-Sheikh, A., Mackman, N., Ruf, W., Liu, C., Edgington, T.S. Arterioscler. Thromb. Vasc. Biol. (2005)
- Sleep deprivation induces the unfolded protein response in mouse cerebral cortex. Naidoo, N., Giang, W., Galante, R.J., Pack, A.I. J. Neurochem. (2005)
- Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Zhao, L., Longo-Guess, C., Harris, B.S., Lee, J.W., Ackerman, S.L. Nat. Genet. (2005)
- Coordination of immunoglobulin chain folding and immunoglobulin chain assembly is essential for the formation of functional IgG. Kaloff, C.R., Haas, I.G. Immunity (1995)
- Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence. Molinari, M., Galli, C., Vanoni, O., Arnold, S.M., Kaufman, R.J. Mol. Cell (2005)
- Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., Mori, M. J. Clin. Invest. (2002)
- Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. Bertolotti, A., Wang, X., Novoa, I., Jungreis, R., Schlessinger, K., Cho, J.H., West, A.B., Ron, D. J. Clin. Invest. (2001)
- Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis. Price, B.D., Mannheim-Rodman, L.A., Calderwood, S.K. J. Cell. Physiol. (1992)
- Expression of glucose-regulated proteins (GRP78 and GRP94) in hearts and fore-limb buds of mouse embryos exposed to hypoglycemia in vitro. Barnes, J.A., Smoak, I.W., Branch, S. Cell Stress Chaperones (1999)
- Expression of a defective mouse mammary tumor virus envelope glycoprotein precursor which binds stably to GRP78 within the lumen of the endoplasmic reticulum is associated with decreased glucocorticoid-induced apoptosis in mouse lymphoma cells. Lam, M., Stallcup, M., Distelhorst, C.W. Cell Death Differ. (1997)
- Modulation of VP-16 cytotoxicity by carboplatin and 41.8 degrees C hyperthermia. Katschinski, D.M., Jacobson, E.L., Wiedemann, G.J., Robins, H.I. J. Cancer Res. Clin. Oncol. (2001)
- Isolation, partial characterisation and immunomodulating activities of polysaccharides from Vernonia kotschyana Sch. Bip. ex Walp. Nergard, C.S., Diallo, D., Michaelsen, T.E., Malterud, K.E., Kiyohara, H., Matsumoto, T., Yamada, H., Paulsen, B.S. Journal of ethnopharmacology. (2004)
- Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis. Hsu, H.C., Zhou, T., Kim, H., Barnes, S., Yang, P., Wu, Q., Zhou, J., Freeman, B.A., Luo, M., Mountz, J.D. Arthritis Rheum. (2006)
- Genomic organization of the mouse Msh4 gene producing bicistronic, chimeric and antisense mRNA. Hirano, M., Noda, T. Gene (2004)
- GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Luo, S., Mao, C., Lee, B., Lee, A.S. Mol. Cell. Biol. (2006)
- The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. Misra, U.K., Gonzalez-Gronow, M., Gawdi, G., Pizzo, S.V. J. Immunol. (2005)
- Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. Misra, U.K., Pizzo, S.V. J. Leukoc. Biol. (2005)
- The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2+ concentration. Zhang, X., Wang, Y., Li, H., Zhang, W., Wu, D., Mi, H. FEBS Lett. (2004)
- KDEL proteins are found on the surface of NG108-15 cells. Xiao, G., Chung, T.F., Pyun, H.Y., Fine, R.E., Johnson, R.J. Brain Res. Mol. Brain Res. (1999)
- Identification of highly conserved regulatory domains and protein-binding sites in the promoters of the rat and human genes encoding the stress-inducible 78-kilodalton glucose-regulated protein. Resendez, E., Wooden, S.K., Lee, A.S. Mol. Cell. Biol. (1988)
- Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. Misra, U.K., Sharma, T., Pizzo, S.V. J. Immunol. (2005)
- Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus. Ray, S., Xu, F., Li, P., Sanchez, N.S., Wang, H., Das, S.K. Endocrinology (2007)
- Expression of the glucose-regulated proteins (GRP94 and GRP78) in differentiated and undifferentiated mouse embryonic cells and the use of the GRP78 promoter as an expression system in embryonic cells. Kim, S.K., Kim, Y.K., Lee, A.S. Differentiation (1990)
- Differential screening of a cDNA library with cDNA probes amplified in a heterologous host: isolation of murine GRP78 (BiP) and other serum-regulated low-abundance mRNAs. Parfett, C.L., Hofbauer, R., Brudzynski, K., Edwards, D.R., Denhardt, D.T. Gene (1989)
- Suppression of stress protein GRP78 induction in tumor B/C10ME eliminates resistance to cell mediated cytotoxicity. Sugawara, S., Takeda, K., Lee, A., Dennert, G. Cancer Res. (1993)
- ADP-ribosylation of the 78-kDa glucose-regulated protein during nutritional stress. Leno, G.H., Ledford, B.E. Eur. J. Biochem. (1989)
- Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. Luo, S., Baumeister, P., Yang, S., Abcouwer, S.F., Lee, A.S. J. Biol. Chem. (2003)
- Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides. Nair, S., Wearsch, P.A., Mitchell, D.A., Wassenberg, J.J., Gilboa, E., Nicchitta, C.V. J. Immunol. (1999)
- Tolbutamide alters glucose transport and metabolism in the embryonic mouse heart. Smoak, I.W. Teratology (2002)
- Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis. Ito, Y., Pandey, P., Mishra, N., Kumar, S., Narula, N., Kharbanda, S., Saxena, S., Kufe, D. Mol. Cell. Biol. (2001)
- Rapid degradation of an unassembled immunoglobulin light chain is mediated by a serine protease and occurs in a pre-Golgi compartment. Gardner, A.M., Aviel, S., Argon, Y. J. Biol. Chem. (1993)