Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

US27 - type 3 membrane protein; 7 transmembrane...

Human herpesvirus 5

This record was discontinued.

Fraile-Ramos, A. et al., Sahagun-Ruiz, A. et al., Penfold, M.E. et al.

Penfold, Schmidt, Dairaghi, Barry, Schall,

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Disease relevance of HHV5gp144

Human cytomegalovirus (CMV) US28 (and the related open reading frame [ORF] US27) are G-protein-coupled receptor homologs believed to play a role in viral pathogenesis [1].

High impact information on HHV5gp144

Antibody-feeding experiments indicated that cell surface US27 undergoes endocytosis [2].
Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes [2].
The intracellular pools of UL33 and US27 showed overlap with markers for endocytic organelles [2].
A related ORF named US27 is adjacent to US28, but no functions have been defined yet [3].

Biological context of HHV5gp144

HCMV US27 and US28 homologues have also been identified in the chimpanzee CMV genome, whereas mouse and rat CMV lack chemokine receptor homologues [3].

References

Characterization of the rhesus cytomegalovirus US28 locus. Penfold, M.E., Schmidt, T.L., Dairaghi, D.J., Barry, P.A., Schall, T.J. J. Virol. (2003) [Pubmed]
Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes. Fraile-Ramos, A., Pelchen-Matthews, A., Kledal, T.N., Browne, H., Schwartz, T.W., Marsh, M. Traffic (2002) [Pubmed]
Simian cytomegalovirus encodes five rapidly evolving chemokine receptor homologues. Sahagun-Ruiz, A., Sierra-Honigmann, A.M., Krause, P., Murphy, P.M. Virus Genes (2004) [Pubmed]

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