The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

CTF1  -  cardiotrophin 1

Homo sapiens

Synonyms: CT-1, CT1, Cardiotrophin-1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of CTF1

 

High impact information on CTF1

 

Chemical compound and disease context of CTF1

  • Using the hepatoma cell line HepG2, we report that the trans-activating function of the nuclear factor I/CCAAT box transcription factor (NFI/CTF-1) is, on the contrary, repressed by various stress conditions, including inflammatory cytokine treatment, glutathione depletion, heat and osmotic shocks, and chemical stress [8].
 

Biological context of CTF1

  • CT-1 induces a hypertrophic response in cardiomyocytes that is distinct from the phenotype seen after alpha-adrenergic stimulation, both with regard to cell morphology and gene expression pattern [1].
  • In the present study we show that CT-1 activates its receptor expressed at the surface of a human neural cell line by recruiting gp130 and gp190/leukemia inhibitory factor receptor beta, as shown by analyzing their tyrosine phosphorylation level [9].
  • Stimulation with CT-1 results in an increase in cardiac cell size that is characterized by an increase in cell length but no significant change in cell width [1].
  • Transient transfection analyses document that, in contrast to alpha-adrenergic stimulation, the CT-1 responsive cis-regulatory elements are located outside of the proximal 3 kilobase pairs of the ANF 5'-flanking region [1].
  • The coding region of CT-1 is contained on three exons and is located on human chromosome 16p11.1-16p11.2 [10].
 

Anatomical context of CTF1

  • Analysis of KB cell line culture supernatants after CT-1 treatment indicates that CT-1 stimulates the production of interleukin 6 (IL-6) in a time- and dose-dependent manner [11].
  • In a search for novel factors that induce cardiac myocyte hypertrophy, cardiotrophin-1 (CT-1) was identified by coupling expression cloning with an embryonic stem cell-based model of cardiogenesis [12].
  • Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways [1].
  • Neutralizing antibody directed against gp130 and reconstitution experiments performed in the COS-7 cell line demonstrate that gp130-gp190 heterocomplex formation is essential for CT-1 signaling [9].
  • CT-1 showed a dose-dependent induction of protein synthesis by primary rat hepatocytes, with effective concentrations ranging from 0.1 to 100 ng/ml [3].
 

Associations of CTF1 with chemical compounds

  • Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance [4].
  • Transcriptional activation in yeast by the proline-rich activation domain of human CTF1 [13].
  • We conclude that CT-1 is stable in specimens of whole blood treated with EDTA and aprotinin and stored for up to 48 hours at room temperature or on ice, hence permitting its development in the routine clinical investigation of patients with heart failure [14].
  • Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation [15].
  • CT-1 increased c-fos and ANP expression (p<0.01) and cell area (p<0.01) in cardiomyocytes from both rat strains [16].
 

Physical interactions of CTF1

  • METHODS AND RESULTS: This study was designed to determine left ventricular expression of CT-1 and its glycoprotein 130 (gp130)/leukemia inhibitory factor receptor complex in human end-stage heart failure due to ischemic and dilated cardiomyopathy [4].
  • HOX11 was shown to interact in vitro and in vivo with CTF1 [17].
  • Western immunoblot and supershift analysis shows that exogenously introduced CTF-1 proteins form different heterodimer complexes with the given subset of endogenous NFI proteins in epithelial or fibroblast cells [18].
 

Regulatory relationships of CTF1

 

Other interactions of CTF1

  • The F284A mutation impaired the biological response induced by LIF and CT-1, whereas the response to OSM remained unchanged [21].
  • This stimulation of IL-6 production by CT-1 is associated with an increase in intracellular levels of IL-6 mRNA [11].
  • Genetic variants in the promoter (g983G>T) and coding region (A92T) of the human cardiotrophin-1 gene (CTF1) in patients with dilated cardiomyopathy [22].
  • Cross-linking of iodinated CT-1 to the cell surface led to the identification of a third alpha component in addition to gp130 and gp190, with an apparent molecular mass of 80 kDa [9].
  • Our results provide evidence that the CT-1 receptor is composed of a tripartite complex, a situation similar to the high affinity receptor for ciliary neurotrophic factor [9].
 

Analytical, diagnostic and therapeutic context of CTF1

References

  1. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways. Wollert, K.C., Taga, T., Saito, M., Narazaki, M., Kishimoto, T., Glembotski, C.C., Vernallis, A.B., Heath, J.K., Pennica, D., Wood, W.I., Chien, K.R. J. Biol. Chem. (1996) [Pubmed]
  2. Expression of members of the interleukin-6 family of cytokines and their receptors in human pituitary and pituitary adenomas. Hanisch, A., Dieterich, K.D., Dietzmann, K., Lüdecke, K., Buchfelder, M., Fahlbusch, R., Lehnert, H. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  3. Murine cardiotrophin-1 stimulates the acute-phase response in rat hepatocytes and H35 hepatoma cells. Richards, C.D., Langdon, C., Pennica, D., Gauldie, J. J. Interferon Cytokine Res. (1996) [Pubmed]
  4. Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance. Zolk, O., Ng, L.L., O'Brien, R.J., Weyand, M., Eschenhagen, T. Circulation (2002) [Pubmed]
  5. The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain. Mermod, N., O'Neill, E.A., Kelly, T.J., Tjian, R. Cell (1989) [Pubmed]
  6. A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3. Alevizopoulos, A., Dusserre, Y., Tsai-Pflugfelder, M., von der Weid, T., Wahli, W., Mermod, N. Genes Dev. (1995) [Pubmed]
  7. Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioning. I??iguez, M., Berasain, C., Martinez-Ans??, E., Bustos, M., Fortes, P., Pennica, D., Avila, M.A., Prieto, J. J. Exp. Med. (2006) [Pubmed]
  8. Nuclear factor I/CCAAT box transcription factor trans-activating domain is a negative sensor of cellular stress. Morel, Y., Coumoul, X., Nalpas, A., Barouki, R. Mol. Pharmacol. (2000) [Pubmed]
  9. Signaling of the cardiotrophin-1 receptor. Evidence for a third receptor component. Robledo, O., Fourcin, M., Chevalier, S., Guillet, C., Auguste, P., Pouplard-Barthelaix, A., Pennica, D., Gascan, H. J. Biol. Chem. (1997) [Pubmed]
  10. Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. Pennica, D., Swanson, T.A., Shaw, K.J., Kuang, W.J., Gray, C.L., Beatty, B.G., Wood, W.I. Cytokine (1996) [Pubmed]
  11. Regulation of interleukin 6 expression by cardiotrophin 1. Robledo, O., Chevalier, S., Froger, J., Barthelaix-Pouplard, A., Pennica, D., Gascan, H. Cytokine (1997) [Pubmed]
  12. Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways. Pennica, D., Wood, W.I., Chien, K.R. Cytokine Growth Factor Rev. (1996) [Pubmed]
  13. Transcriptional activation in yeast by the proline-rich activation domain of human CTF1. Kim, T.K., Roeder, R.G. J. Biol. Chem. (1993) [Pubmed]
  14. Prolonged stability of endogenous cardiotrophin-1 in whole blood. Downie, P.F., Talwar, S., Squire, I.B., Davies, J.E., Ng, L.L. Metab. Clin. Exp. (2001) [Pubmed]
  15. Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation. Funamoto, M., Hishinuma, S., Fujio, Y., Matsuda, Y., Kunisada, K., Oh, H., Negoro, S., Tone, E., Kishimoto, T., Yamauchi-Takihara, K. J. Mol. Cell. Cardiol. (2000) [Pubmed]
  16. Differential hypertrophic effects of cardiotrophin-1 on adult cardiomyocytes from normotensive and spontaneously hypertensive rats. L??pez, N., D??ez, J., Fortu??o, M.A. J. Mol. Cell. Cardiol. (2006) [Pubmed]
  17. HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization. Zhang, N., Shen, W., Hawley, R.G., Lu, M. Oncogene (1999) [Pubmed]
  18. Nuclear factor I and epithelial cell-specific transcription of human papillomavirus type 16. Apt, D., Chong, T., Liu, Y., Bernard, H.U. J. Virol. (1993) [Pubmed]
  19. Proline-rich activator CTF1 targets the TFIIB assembly step during transcriptional activation. Kim, T.K., Roeder, R.G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  20. Cardiotrophin-1 induces monocyte chemoattractant protein-1 synthesis in human umbilical vein endothelial cells. Fritzenwanger, M., Kuethe, F., Haase, D., Jandt, E., Figulla, H.R. Cytokine (2006) [Pubmed]
  21. Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor. Plun-Favreau, H., Perret, D., Diveu, C., Froger, J., Chevalier, S., Lelièvre, E., Gascan, H., Chabbert, M. J. Biol. Chem. (2003) [Pubmed]
  22. Genetic variants in the promoter (g983G>T) and coding region (A92T) of the human cardiotrophin-1 gene (CTF1) in patients with dilated cardiomyopathy. Erdmann, J., Hassfeld, S., Kallisch, H., Fleck, E., Regitz-Zagrose, V. Hum. Mutat. (2000) [Pubmed]
  23. The heart is a source of circulating cardiotrophin-1 in humans. Asai, S., Saito, Y., Kuwahara, K., Mizuno, Y., Yoshimura, M., Higashikubo, C., Tsuji, T., Kishimoto, I., Harada, M., Hamanaka, I., Takahashi, N., Yasue, H., Nakao, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  24. Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3. Auernhammer, C.J., Isele, N.B., Kopp, F.B., Spoettl, G., Cengic, N., Weber, M.M., Senaldi, G., Engelhardt, D. Endocrinology (2003) [Pubmed]
 
WikiGenes - Universities