Gene Review:
CTLA4 - cytotoxic T-lymphocyte-associated protein 4
Homo sapiens
Synonyms:
ALPS5, CD, CD152, CD28, CELIAC3, ...
- Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study. Graham, D.S., Wong, A.K., McHugh, N.J., Whittaker, J.C., Vyse, T.J. Hum. Mol. Genet. (2006)
- Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Marron, M.P., Raffel, L.J., Garchon, H.J., Jacob, C.O., Serrano-Rios, M., Martinez Larrad, M.T., Teng, W.P., Park, Y., Zhang, Z.X., Goldstein, D.R., Tao, Y.W., Beaurain, G., Bach, J.F., Huang, H.S., Luo, D.F., Zeidler, A., Rotter, J.I., Yang, M.C., Modilevsky, T., Maclaren, N.K., She, J.X. Hum. Mol. Genet. (1997)
- A CTLA4high genotype is associated with myasthenia gravis in thymoma patients. Chuang, W.Y., Ströbel, P., Gold, R., Nix, W., Schalke, B., Kiefer, R., Opitz, A., Klinker, E., Müller-Hermelink, H.K., Marx, A. Ann. Neurol. (2005)
- Interactions of CD80 and CD86 with CD28 and CTLA4. Ellis, J.H., Burden, M.N., Vinogradov, D.V., Linge, C., Crowe, J.S. J. Immunol. (1996)
- No evidence for an association of the CTLA4 gene with bipolar I disorder. Jun, T.Y., Lee, K.U., Pae, C.U., Kweon, Y.S., Chae, J.H., Bahk, W.M., Kim, K.S., Lew, T.Y., Han, H. Psychiatry and clinical neurosciences. (2004)
- Neurologic presentation of celiac disease. Bushara, K.O. Gastroenterology (2005)
- CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques. Hryniewicz, A., Boasso, A., Edghill-Smith, Y., Vaccari, M., Fuchs, D., Venzon, D., Nacsa, J., Betts, M.R., Tsai, W.P., Heraud, J.M., Beer, B., Blanset, D., Chougnet, C., Lowy, I., Shearer, G.M., Franchini, G. Blood (2006)
- Celiac disease, brain atrophy, and dementia. Collin, P., Pirttilä, T., Nurmikko, T., Somer, H., Erilä, T., Keyriläinen, O. Neurology (1991)
- Frequency and clinical pattern of celiac disease among siblings of celiac children. Bonamico, M., Mariani, P., Mazzilli, M.C., Triglione, P., Lionetti, P., Ferrante, P., Picarelli, A., Mesturino, A., Gemme, G., Imperato, C. J. Pediatr. Gastroenterol. Nutr. (1996)
- The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Carreno, B.M., Collins, M. Annu. Rev. Immunol. (2002)
- CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Chambers, C.A., Kuhns, M.S., Egen, J.G., Allison, J.P. Annu. Rev. Immunol. (2001)
- Molecular basis of celiac disease. Sollid, L.M. Annu. Rev. Immunol. (2000)
- Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection. Yee, L.J., Perez, K.A., Tang, J., van Leeuwen, D.J., Kaslow, R.A. J. Infect. Dis. (2003)
- Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands. Hufton, S.E., van Neer, N., van den Beuken, T., Desmet, J., Sablon, E., Hoogenboom, H.R. FEBS Lett. (2000)
- Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease. Donner, H., Braun, J., Seidl, C., Rau, H., Finke, R., Ventz, M., Walfish, P.G., Usadel, K.H., Badenhoop, K. J. Clin. Endocrinol. Metab. (1997)
- Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. Barcellos, L.F., Kamdar, B.B., Ramsay, P.P., Deloa, C., Lincoln, R.R., Caillier, S., Schmidt, S., Haines, J.L., Pericak-Vance, M.A., Oksenberg, J.R., Hauser, S.L. Lancet neurology. (2006)
- Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Wu, G.S., Saftig, P., Peters, C., El-Deiry, W.S. Oncogene (1998)
- CD28 and apoptosis. Boise, L.H., Noel, P.J., Thompson, C.B. Curr. Opin. Immunol. (1995)
- Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Butty, V., Roy, M., Sabeti, P., Besse, W., Benoist, C., Mathis, D. Proc. Natl. Acad. Sci. U.S.A. (2007)
- The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity. Hermann, R., Laine, A.P., Veijola, R., Vahlberg, T., Simell, S., Lähde, J., Simell, O., Knip, M., Ilonen, J. Diabetologia (2005)
- A pathway of costimulation that prevents anergy in CD28- T cells: B7-independent costimulation of CD1-restricted T cells. Behar, S.M., Porcelli, S.A., Beckman, E.M., Brenner, M.B. J. Exp. Med. (1995)
- Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. Tan, P.H., Yates, J.B., Xue, S.A., Chan, C., Jordan, W.J., Harper, J.E., Watson, M.P., Dong, R., Ritter, M.A., Lechler, R.I., Lombardi, G., George, A.J. Blood (2005)
- Expression of functional B7 and CTLA4 on rheumatoid synovial T cells. Verwilghen, J., Lovis, R., De Boer, M., Linsley, P.S., Haines, G.K., Koch, A.E., Pope, R.M. J. Immunol. (1994)
- Inhibition by CTLA4Ig of experimental allergic encephalomyelitis. Arima, T., Rehman, A., Hickey, W.F., Flye, M.W. J. Immunol. (1996)
- Arterial and venular endothelial cell costimulation of cytokine secretion by human T cell clones. Johnson, D.R., Hauser, I.A., Voll, R.E., Emmrich, F. J. Leukoc. Biol. (1998)
- Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail. Leung, H.T., Bradshaw, J., Cleaveland, J.S., Linsley, P.S. J. Biol. Chem. (1995)
- Cyclic adenosine 5'-monophosphate and calcium induce CD152 (CTLA-4) up-regulation in resting CD4+ T lymphocytes. Vendetti, S., Riccomi, A., Sacchi, A., Gatta, L., Pioli, C., De Magistris, M.T. J. Immunol. (2002)
- Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7. Vaughan, A.N., Malde, P., Rogers, N.J., Jackson, I.M., Lechler, R.I., Dorling, A. J. Immunol. (2000)
- CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. van der Merwe, P.A., Bodian, D.L., Daenke, S., Linsley, P., Davis, S.J. J. Exp. Med. (1997)
- Functional expression of a costimulatory B7.2 (CD86) protein on human salivary gland epithelial cells that interacts with the CD28 receptor, but has reduced binding to CTLA4. Kapsogeorgou, E.K., Moutsopoulos, H.M., Manoussakis, M.N. J. Immunol. (2001)
- CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription. Srahna, M., Van Grunsven, L.A., Remacle, J.E., Vandenberghe, P. Immunology (2006)
- CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. Schneider, H., Prasad, K.V., Shoelson, S.E., Rudd, C.E. J. Exp. Med. (1995)
- Ovine dendritic cells transduced with an adenoviral CTLA4eEGFP fusion protein construct induce hyporesponsiveness to allostimulation. Newland, A., Kireta, S., Russ, G., Krishnan, R. Immunology (2004)
- Relationship between CTLA-4 and CD28 molecule expression on T lymphocytes and stimulating and blocking autoantibodies to the TSH-receptor in children with Graves' disease. Bossowski, A., Stasiak-Barmuta, A., Urban, M. Horm. Res. (2005)
- ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement. Riley, J.L., Blair, P.J., Musser, J.T., Abe, R., Tezuka, K., Tsuji, T., June, C.H. J. Immunol. (2001)
- Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. Gibson, H.M., Hedgcock, C.J., Aufiero, B.M., Wilson, A.J., Hafner, M.S., Tsokos, G.C., Wong, H.K. J. Immunol. (2007)
- Soluble CD86 is a costimulatory molecule for human T lymphocytes. Jeannin, P., Magistrelli, G., Aubry, J.P., Caron, G., Gauchat, J.F., Renno, T., Herbault, N., Goetsch, L., Blaecke, A., Dietrich, P.Y., Bonnefoy, J.Y., Delneste, Y. Immunity (2000)
- Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Boussiotis, V.A., Freeman, G.J., Gribben, J.G., Daley, J., Gray, G., Nadler, L.M. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte-associated antigen 4, and programmed cell death 1 in primary Sjögren's syndrome. Bolstad, A.I., Eiken, H.G., Rosenlund, B., Alarcón-Riquelme, M.E., Jonsson, R. Arthritis Rheum. (2003)
- Expression and function of a CD5 cDNA in human and murine T cells. Nishimura, Y., Bierer, B.E., Jones, W.K., Jones, N.H., Strominger, J.L., Burakoff, S.J. Eur. J. Immunol. (1988)
- CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. Bergholdt, R., Taxvig, C., Eising, S., Nerup, J., Pociot, F. J. Leukoc. Biol. (2005)
- The codon 17 polymorphism of the CTLA4 gene in type 2 diabetes mellitus. Rau, H., Braun, J., Donner, H., Seissler, J., Siegmund, T., Usadel, K.H., Badenhoop, K. J. Clin. Endocrinol. Metab. (2001)
- In vivo expression of the CTLA4 inhibitory receptor in malignant and reactive cells from human lymphomas. Xerri, L., Devilard, E., Hassoun, J., Olive, D., Birg, F. J. Pathol. (1997)
- Local gene therapy with CTLA4-immunoglobulin fusion protein in experimental allergic encephalomyelitis. Croxford, J.L., O'Neill, J.K., Ali, R.R., Browne, K., Byrnes, A.P., Dallman, M.J., Wood, M.J., Fedlmann, M., Baker, D. Eur. J. Immunol. (1998)