Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

HEVgp08 - RNA-directed RNA polymerase

Hepatitis E virus

This record was discontinued.

Reyes, G.R. et al., Tam, A.W. et al.

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Disease relevance of HEVgp08

The translated nucleic acid sequence of a portion of ET1.1 had a consensus amino acid motif consistent with an RNA-directed RNA polymerase; this enzyme is present in all positive strand RNA viruses [1].

High impact information on HEVgp08

The largest open reading frame extends approximately 5 kb from the 5' end and contains the RNA-directed RNA polymerase and nucleoside triphosphate binding motifs [2].

References

Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Reyes, G.R., Purdy, M.A., Kim, J.P., Luk, K.C., Young, L.M., Fry, K.E., Bradley, D.W. Science (1990) [Pubmed]
Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Tam, A.W., Smith, M.M., Guerra, M.E., Huang, C.C., Bradley, D.W., Fry, K.E., Reyes, G.R. Virology (1991) [Pubmed]

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