Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

U86 - IE-A

Human herpesvirus 6

Nikolaou, K. et al., Papanikolaou, E. et al., Dominguez, G. et al., Takemoto, M. et al.

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Disease relevance of U86

HHV-6 has three repetitive elements, R1, R2, and R3, in or near the IE-A locus [1].
This region includes the immediate early A (IE-A) locus that was defined as positional homologue of the major IE locus of Human cytomegalovirus (HCMV) with little recognizable sequence homologies [2].

High impact information on U86

The most divergent regions are DR and the right end of U, spanning ORFs U86 to U100 [3].
However, the HHV-6 IE-A locus exhibits limited sequence homology with the HCMV MIE locus [4].

References

The R3 region, one of three major repetitive regions of human herpesvirus 6, is a strong enhancer of immediate-early gene U95. Takemoto, M., Shimamoto, T., Isegawa, Y., Yamanishi, K. J. Virol. (2001) [Pubmed]
Identification and characterization of gene products of ORF U90/89 of human herpesvirus 6. Nikolaou, K., Varinou, L., Inoue, N., Arsenakis, M. Acta Virol. (2003) [Pubmed]
Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. Dominguez, G., Dambaugh, T.R., Stamey, F.R., Dewhurst, S., Inoue, N., Pellett, P.E. J. Virol. (1999) [Pubmed]
Identification and characterization of the gene products of open reading frame U86/87 of human herpesvirus 6. Papanikolaou, E., Kouvatsis, V., Dimitriadis, G., Inoue, N., Arsenakis, M. Virus Res. (2002) [Pubmed]

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