Gene Review:
ADRA2A - adrenoceptor alpha 2A
Homo sapiens
Synonyms:
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, Alpha-2 adrenergic receptor subtype C10, ...
- Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks? Li, J.L., Canham, R.M., Vongpatanasin, W., Leonard, D., Auchus, R.J., Victor, R.G. Hypertension (2006)
- A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents. Surprenant, A., Horstman, D.A., Akbarali, H., Limbird, L.E. Science (1992)
- Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. Liggett, S.B., Caron, M.G., Lefkowitz, R.J., Hnatowich, M. J. Biol. Chem. (1991)
- Regulation of the alpha 2A-adrenergic receptor in the HT29 cell line. Effects of insulin and growth factors. Devedjian, J.C., Fargues, M., Denis-Pouxviel, C., Daviaud, D., Prats, H., Paris, H. J. Biol. Chem. (1991)
- Further evidence of the involvement of alpha-2A-adrenergic receptor gene (ADRA2A) in inattentive dimensional scores of attention-deficit/hyperactivity disorder. Roman, T., Polanczyk, G.V., Zeni, C., Genro, J.P., Rohde, L.A., Hutz, M.H. Mol. Psychiatry (2006)
- Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disorders. Ohara, K., Nagai, M., Tani, K., Tsukamoto, T., Suzuki, Y., Ohara, K. Neuroreport (1998)
- The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation. Eason, M.G., Jacinto, M.T., Theiss, C.T., Liggett, S.B. Proc. Natl. Acad. Sci. U.S.A. (1994)
- An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. Small, K.M., Forbes, S.L., Brown, K.M., Liggett, S.B. J. Biol. Chem. (2000)
- Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor. Eason, M.G., Moreira, S.P., Liggett, S.B. J. Biol. Chem. (1995)
- Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. Hawes, B.E., van Biesen, T., Koch, W.J., Luttrell, L.M., Lefkowitz, R.J. J. Biol. Chem. (1995)
- Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. Hawes, B.E., Luttrell, L.M., Exum, S.T., Lefkowitz, R.J. J. Biol. Chem. (1994)
- The alpha-2A adrenoceptor agonist guanfacine improves sustained attention and reduces overactivity and impulsiveness in an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD). Sagvolden, T. Behavioral and brain functions : BBF (2006)
- Variations in the alpha2A-adrenergic receptor gene and their functional effects. Kurnik, D., Muszkat, M., Li, C., Sofowora, G.G., Solus, J., Xie, H.G., Harris, P.A., Jiang, L., McMunn, C., Ihrie, P., Dawson, E.P., Williams, S.M., Wood, A.J., Stein, C.M. Clin. Pharmacol. Ther. (2006)
- The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study. Garenc, C., Pérusse, L., Chagnon, Y.C., Rankinen, T., Gagnon, J., Borecki, I.B., Leon, A.S., Skinner, J.S., Wilmore, J.H., Rao, D.C., Bouchard, C. Mol. Med. (2002)
- A polymorphism in the alpha2a-adrenoceptor gene and endurance athlete status. Wolfarth, B., Rivera, M.A., Oppert, J.M., Boulay, M.R., Dionne, F.T., Chagnon, M., Gagnon, J., Chagnon, Y., Perusse, L., Keul, J., Bouchard, C. Medicine and science in sports and exercise. (2000)
- Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements. Boucher, J., Castan-Laurell, I., Le Lay, S., Grujic, D., Sibrac, D., Krief, S., Lafontan, M., Lowell, B.B., Dugail, I., Saulnier-Blache, J.S., Valet, P. J. Mol. Endocrinol. (2002)
- Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. Schambra, U.B., Mackensen, G.B., Stafford-Smith, M., Haines, D.E., Schwinn, D.A. Neuroscience (2005)
- Dynamic strength training improves insulin sensitivity and functional balance between adrenergic alpha 2A and beta pathways in subcutaneous adipose tissue of obese subjects. Polak, J., Moro, C., Klimcakova, E., Hejnova, J., Majercik, M., Viguerie, N., Langin, D., Lafontan, M., Stich, V., Berlan, M. Diabetologia (2005)
- Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists. Wang, C.D., Buck, M.A., Fraser, C.M. Mol. Pharmacol. (1991)
- Attention-deficit/hyperactivity disorder: advancing on pharmacogenomics. Polanczyk, G., Zeni, C., Genro, J.P., Roman, T., Hutz, M.H., Rohde, L.A. Pharmacogenomics (2005)
- Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. Piletz, J.E., Zhu, H., Chikkala, D.N. J. Pharmacol. Exp. Ther. (1996)
- Identification of ADRA2A polymorphisms related to shear-mediated platelet function. Yabe, M., Matsubara, Y., Takahashi, S., Ishihara, H., Shibano, T., Miyaki, K., Omae, K., Watanabe, G., Murata, M., Ikeda, Y. Biochem. Biophys. Res. Commun. (2006)
- A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. Rosmond, R., Bouchard, C., Björntorp, P. J. Intern. Med. (2002)
- Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor. Airriess, C.N., Rudling, J.E., Midgley, J.M., Evans, P.D. Br. J. Pharmacol. (1997)
- Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. Liggett, S.B., Ostrowski, J., Chesnut, L.C., Kurose, H., Raymond, J.R., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1992)
- Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor. Bahia, D.S., Wise, A., Fanelli, F., Lee, M., Rees, S., Milligan, G. Biochemistry (1998)
- Association and linkage of alpha-2A adrenergic receptor gene polymorphisms with childhood ADHD. Park, L., Nigg, J.T., Waldman, I.D., Nummy, K.A., Huang-Pollock, C., Rappley, M., Friderici, K.H. Mol. Psychiatry (2005)
- Detailed physical analysis of a 1.5-megabase YAC contig containing the MXI1 and ADRA2A genes. Manca, A., Volpi, E.V., Laficara, F., Muresu, R., Gray, I.C., Spurr, N.K., Nobile, C. Genomics (1997)
- Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. Belfer, I., Buzas, B., Hipp, H., Phillips, G., Taubman, J., Lorincz, I., Evans, C., Lipsky, R.H., Enoch, M.A., Max, M.B., Goldman, D. J. Hum. Genet. (2005)
- Evaluation of the genes for the adrenergic receptors alpha 2A and alpha 1C and Gilles de la Tourette Syndrome. Xu, C., Ozbay, F., Wigg, K., Shulman, R., Tahir, E., Yazgan, Y., Sandor, P., Barr, C.L. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003)
- Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling. Eason, M.G., Liggett, S.B. J. Biol. Chem. (1995)
- Promoter region of the human alpha 2A adrenergic receptor gene. Handy, D.E., Gavras, H. J. Biol. Chem. (1992)