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Gene Review: 

ABCC13  -  ATP-binding cassette, sub-family C...

Homo sapiens

Synonyms: C21orf73, PRED6
 
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High impact information on ABCC13

  • Here we show that while comparative analysis and in silico prediction methods indicate the presence of at least 28 exons, the major ABCC13 transcript in humans consists of only 6 exons with a total length of 1.1 kb [1].
  • The expression of ABCC13 in K562 cells decreased during cell differentiation induced by TPA [2].
  • The open reading frame of the ABCC13 cDNA encodes a peptide consisting of 325 amino acid residues [2].
  • These results suggest that the expression of human ABCC13 is related with hematopoiesis [2].
  • While ABCC13 was expressed in the bone marrow, its expression in peripheral blood leukocytes of adult humans was much lower and no detectable levels were observed in differentiated hematopoietic cells [2].
 

Biological context of ABCC13

References

  1. Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages. Annilo, T., Dean, M. Genomics (2004)
  2. ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver. Yabuuchi, H., Takayanagi, S., Yoshinaga, K., Taniguchi, N., Aburatani, H., Ishikawa, T. Biochem. Biophys. Res. Commun. (2002)
 

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