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CCT8L2  -  chaperonin containing TCP1, subunit 8...

Homo sapiens

Synonyms: CESK1
 
 
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Disease relevance of CESK1

  • Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1 [1].
  • Michal upon microscopic examination of the rat's cornea, found nuclear pyknosis, edema and separation of cells in the eye following exposures for 3h at 36ppm H(2)S [Michal FV. Eye lesions caused by hydrogen sulfide. Cesk Ophthalmol 1950;6;5-8] [2].
  • Based on a differentially displayed cDNA fragment, which was down regulated in hepatoma tissues, we cloned a novel cDNA of 957 bp, TCP10L (T-complex protein 10 like), from the human liver cDNA library [3].
  • A case of cystic embryonal sarcoma of the kidney (CESK) with a rapidly fatal outcome was recently reported.1 Here, we report another case of a 12-year-old boy with a localized but ill-defined submucosal lesion of CESK in the right renal pelvis [4].
 

High impact information on CESK1

  • T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol [5].
  • The lethal 't alleles' of the T complex on mouse chromosome 17 (refs 1, 2) have been assigned to six complementation groups (the definitive classes being t0, t9, t12, tw1, tw5 and tw73), each causing embryonic death at a particular stage [6].
  • The amino acid sequence encoded by one of the cDNA clones is related to T-complex proteins, which suggests a "chaperonin"-like function [7].
  • T-complex polypeptide-1 interacts with the erythrocyte cytoskeleton in response to elevated temperatures [8].
  • When the pure alpha T.GDP complex is added to lipid vesicles containing rhodopsin and the beta gamma T complex, a light- and guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S)-dependent enhancement of the fluorescence emission of alpha T is observed [9].
 

Biological context of CESK1

 

Anatomical context of CESK1

 

Associations of CESK1 with chemical compounds

  • Here we characterise a further three of the 18 proteins as: manganese superoxide dismutase, 6q25.3, T-complex protein 1, 6q25.3-q26 and collapsin response mediator protein 2, 8p21 [18].
  • Consistent amplitude and latency correlations were found between the obligatory AEP components P1, N1b and P2 recorded at C3 and C4 and the T-complex components measured at T5 and T6, but not T3 and T4 [12].
  • CONCLUSIONS: Distinct patterns of AEP maturation were measured at electrode sites commonly used to record the T-complex [12].
  • However, the T complex could not be identified in 7 LI children and 1 C child [19].
 

Other interactions of CESK1

 

Analytical, diagnostic and therapeutic context of CESK1

  • Cucumber T-complex protein. Molecular cloning, bacterial expression and characterization within a 22-S cytosolic complex in cotyledons and hypocotyls [25].

References

  1. Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1. Yoo, B.C., Fountoulakis, M., Dierssen, M., Lubec, G. J. Neural Transm. Suppl. (2001) [Pubmed]
  2. Hydrogen sulfide (H2S) and sour gas effects on the eye. A historical perspective. Lambert, T.W., Goodwin, V.M., Stefani, D., Strosher, L. Sci. Total Environ. (2006) [Pubmed]
  3. Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity. Chen, Z., Yu, L., Wu, H., Yu, J., Zhang, L., Jiang, D., Ma, L., Li, D., Zhao, S. J. Hum. Genet. (2003) [Pubmed]
  4. Embryonal sarcoma of adult and pediatric kidneys: report of a case with localized submucosal invasion of the renal pelvis and long-term survival. Ito, J., Monobe, Y., Sakamoto, K., Tanaka, H. Pathol. Int. (2000) [Pubmed]
  5. T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol. Lewis, V.A., Hynes, G.M., Zheng, D., Saibil, H., Willison, K. Nature (1992) [Pubmed]
  6. Explanation of sterility in txty male mice. Tucker, M.J. Nature (1980) [Pubmed]
  7. Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA. Segel, G.B., Boal, T.R., Cardillo, T.S., Murant, F.G., Lichtman, M.A., Sherman, F. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. T-complex polypeptide-1 interacts with the erythrocyte cytoskeleton in response to elevated temperatures. Wagner, C.T., Lu, I.Y., Hoffman, M.H., Sun, W.Q., Trent, J.D., Connor, J. J. Biol. Chem. (2004) [Pubmed]
  9. The intrinsic fluorescence of the alpha subunit of transducin. Measurement of receptor-dependent guanine nucleotide exchange. Phillips, W.J., Cerione, R.A. J. Biol. Chem. (1988) [Pubmed]
  10. The ascendency of developmental genetics, or how the T complex educated a generation of developmental biologists. Papaioannou, V.E. Genetics (1999) [Pubmed]
  11. Linkage mapping and fluorescence in situ hybridization of TCTE1 on human chromosome 6p: analysis of dinucleotide polymorphisms on native gels. Kwiatkowski, T.J., Beaudet, A.L., Trask, B.J., Zoghbi, H.Y. Genomics (1991) [Pubmed]
  12. Maturation of human central auditory system activity: the T-complex. Tonnquist-Uhlen, I., Ponton, C.W., Eggermont, J.J., Kwong, B., Don, M. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2003) [Pubmed]
  13. RNA differential display of scarless wound healing in fetal rabbit indicates downregulation of a CCT chaperonin subunit and upregulation of a glycophorin-like gene transcript. Darden, D.L., Hu, F.Z., Ehrlich, M.D., Gorry, M.C., Dressman, D., Li, H.S., Whitcomb, D.C., Hebda, P.A., Dohar, J.E., Ehrlich, G.D. J. Pediatr. Surg. (2000) [Pubmed]
  14. Evidence for association between single nucleotide polymorphisms in T complex protein 1 gene and schizophrenia in the Chinese Han population. Yang, M.S., Yu, L., Guo, T.W., Zhu, S.M., Liu, H.J., Shi, Y.Y., Gu, N.F., Feng, G.Y., He, L. J. Med. Genet. (2004) [Pubmed]
  15. Spermatocytes and round spermatids of rat testis: protein patterns. Cossio, G., Sanchez, J.C., Golaz, O., Wettstein, R., Hochstrasser, D.F. Electrophoresis (1995) [Pubmed]
  16. T complex hemispheric asymmetries: effects of stimulus intensity. Cacace, A.T., Dowman, R., Wolpaw, J.R. Hear. Res. (1988) [Pubmed]
  17. Late auditory evoked potentials can occur without brain stem potentials. Satya-Murti, S., Wolpaw, J.R., Cacace, A.T., Schaffer, C.A. Electroencephalography and clinical neurophysiology. (1983) [Pubmed]
  18. Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia. Edgar, P.F., Douglas, J.E., Cooper, G.J., Dean, B., Kydd, R., Faull, R.L. Mol. Psychiatry (2000) [Pubmed]
  19. Topography of auditory evoked long-latency potentials in children with severe language impairment: the T complex. Tonnquist-Uhlén, I. Acta Otolaryngol. (1996) [Pubmed]
  20. Origin of gene overlap: the case of TCP1 and ACAT2. Shintani, S., O'hUigin, C., Toyosawa, S., Michalová, V., Klein, J. Genetics (1999) [Pubmed]
  21. A differential proteomic approach to identify proteins associated with thyroid cell transformation. Paron, I., D'Ambrosio, C., Scaloni, A., Berlingieri, M.T., Pallante, P.L., Fusco, A., Bivi, N., Tell, G., Damante, G. J. Mol. Endocrinol. (2005) [Pubmed]
  22. Utility of peptide-protein affinity complexes in proteomics: identification of interaction partners of a tumor suppressor peptide. Gururaja, T.L., Li, W., Payan, D.G., Anderson, D.C. J. Pept. Res. (2003) [Pubmed]
  23. Modulation of antigen-induced T cell proliferation by alpha 2M-trypsin complexes. Mannhalter, J.W., Borth, W., Eibl, M.M. J. Immunol. (1986) [Pubmed]
  24. Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress. Nakamura, M., Yamada, M., Ohsawa, T., Morisawa, H., Nishine, T., Nishimura, O., Toda, T. Biochim. Biophys. Acta (2006) [Pubmed]
  25. Cucumber T-complex protein. Molecular cloning, bacterial expression and characterization within a 22-S cytosolic complex in cotyledons and hypocotyls. Ahnert, V., May, C., Gerke, R., Kindl, H. Eur. J. Biochem. (1996) [Pubmed]
 
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