Gene Review:
CTSB - cathepsin B
Homo sapiens
Synonyms:
APP secretase, APPS, CPSB, Cathepsin B, Cathepsin B1
- A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma. Hughes, S.J., Glover, T.W., Zhu, X.X., Kuick, R., Thoraval, D., Orringer, M.B., Beer, D.G., Hanash, S. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Identification of two new exons and multiple transcription start points in the 5'-untranslated region of the human cathepsin-B-encoding gene. Berquin, I.M., Cao, L., Fong, D., Sloane, B.F. Gene (1995)
- Human cathepsin B-encoding cDNAs: sequence variations in the 3'-untranslated region. Tam, S.W., Cote-Paulino, L.R., Peak, D.A., Sheahan, K., Murnane, M.J. Gene (1994)
- Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo. Menzel, K., Hausmann, M., Obermeier, F., Schreiter, K., Dunger, N., Bataille, F., Falk, W., Scholmerich, J., Herfarth, H., Rogler, G. Clin. Exp. Immunol. (2006)
- A polymorphic marker for the human cathepsin B gene. MacKenzie, J.R., Mason, S.L., Hickford, J.G., Kohonen-Corish, M.R., Bickerstaffe, R. Mol. Cell. Probes (2001)
- Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: inverse correlation with severity of dementia and effect of apolipoprotein E genotype. Nitsch, R.M., Rebeck, G.W., Deng, M., Richardson, U.I., Tennis, M., Schenk, D.B., Vigo-Pelfrey, C., Lieberburg, I., Wurtman, R.J., Hyman, B.T. Ann. Neurol. (1995)
- Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme. Tagawa, K., Kunishita, T., Maruyama, K., Yoshikawa, K., Kominami, E., Tsuchiya, T., Suzuki, K., Tabira, T., Sugita, H., Ishiura, S. Biochem. Biophys. Res. Commun. (1991)
- Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells. Lugini, L., Matarrese, P., Tinari, A., Lozupone, F., Federici, C., Iessi, E., Gentile, M., Luciani, F., Parmiani, G., Rivoltini, L., Malorni, W., Fais, S. Cancer Res. (2006)
- Increased cathepsin B activity in pancreatic juice from a patient with pancreatic cancer. Rinderknecht, H., Renner, I.G. N. Engl. J. Med. (1980)
- A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Miyazaki, K., Hasegawa, M., Funahashi, K., Umeda, M. Nature (1993)
- Tumor cell-platelet aggregation: induced by cathepsin B-like proteinase and inhibited by prostacyclin. Honn, K.V., Cavanaugh, P., Evens, C., Taylor, J.D., Sloane, B.F. Science (1982)
- Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Riese, R.J., Wolf, P.R., Brömme, D., Natkin, L.R., Villadangos, J.A., Ploegh, H.L., Chapman, H.A. Immunity (1996)
- Expression of Cathepsin B and L antigen and activity is associated with early colorectal cancer progression. Troy, A.M., Sheahan, K., Mulcahy, H.E., Duffy, M.J., Hyland, J.M., O'Donoghue, D.P. Eur. J. Cancer (2004)
- Estrogen-induced lysosomal proteases secreted by breast cancer cells: a role in carcinogenesis? Rochefort, H., Capony, F., Garcia, M., Cavaillès, V., Freiss, G., Chambon, M., Morisset, M., Vignon, F. J. Cell. Biochem. (1987)
- Cathepsin B- and L-like activities at local gingival sites of chronic periodontitis patients. Eley, B.M., Cox, S.W. Journal of clinical periodontology. (1991)
- Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. Olivotto, E., Vitellozzi, R., Fernandez, P., Falcieri, E., Battistelli, M., Burattini, S., Facchini, A., Flamigni, F., Santi, S., Facchini, A., Borzi', R.M. J. Cell. Physiol. (2007)
- Plasma membrane association of cathepsin B in human prostate cancer: biochemical and immunogold electron microscopic analysis. Sinha, A.A., Jamuar, M.P., Wilson, M.J., Rozhin, J., Sloane, B.F. Prostate (2001)
- Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B. Redzynia, I., Ljunggren, A., Abrahamson, M., Mort, J.S., Krupa, J.C., Jaskolski, M., Bujacz, G. J. Biol. Chem. (2008)
- Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. Cao, L., Taggart, R.T., Berquin, I.M., Moin, K., Fong, D., Sloane, B.F. Gene (1994)
- Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity. Brömme, D., Bonneau, P.R., Lachance, P., Storer, A.C. J. Biol. Chem. (1994)
- Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma. Niedergethmann, M., Wostbrock, B., Sturm, J.W., Willeke, F., Post, S., Hildenbrand, R. Pancreas (2004)
- Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme. Spizz, G., Blackshear, P.J. J. Biol. Chem. (1997)
- Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance. Michallet, M.C., Saltel, F., Flacher, M., Revillard, J.P., Genestier, L. J. Immunol. (2004)
- Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis. Cunnane, G., FitzGerald, O., Hummel, K.M., Youssef, P.P., Gay, R.E., Gay, S., Bresnihan, B. Arthritis Rheum. (2001)
- Strong immunoreactivity of cathepsin L at the site of rimmed vacuoles in diseased muscles. Jimi, T., Satoh, Y., Takeda, A., Shibuya, S., Wakayama, Y., Sugita, K. Brain (1992)
- Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. Taha, T.A., Kitatani, K., Bielawski, J., Cho, W., Hannun, Y.A., Obeid, L.M. J. Biol. Chem. (2005)
- Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane. Ma, D.H., Yao, J.Y., Kuo, M.T., See, L.C., Lin, K.Y., Chen, S.C., Chen, J.K., Chao, A.S., Wang, S.F., Lin, K.K. Invest. Ophthalmol. Vis. Sci. (2007)
- Cathepsin L activity in alveolar macrophages of rats: response to cigarette smoke. Lesser, M., Galicki, N., Cardozo, C., Gariola, C.G. Am. J. Respir. Cell Mol. Biol. (1989)
- Cell surface complex of cathepsin B/annexin II tetramer in malignant progression. Mai, J., Waisman, D.M., Sloane, B.F. Biochim. Biophys. Acta (2000)
- Human sputum cathepsin B degrades proteoglycan, is inhibited by alpha 2-macroglobulin and is modulated by neutrophil elastase cleavage of cathepsin B precursor and cystatin C. Buttle, D.J., Abrahamson, M., Burnett, D., Mort, J.S., Barrett, A.J., Dando, P.M., Hill, S.L. Biochem. J. (1991)
- Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. Rao, N.K., Shi, G.P., Chapman, H.A. J. Clin. Invest. (1995)
- The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. Musil, D., Zucic, D., Turk, D., Engh, R.A., Mayr, I., Huber, R., Popovic, T., Turk, V., Towatari, T., Katunuma, N. EMBO J. (1991)
- Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. Guncar, G., Klemencic, I., Turk, B., Turk, V., Karaoglanovic-Carmona, A., Juliano, L., Turk, D. Structure (2000)
- Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA). Kobayashi, H., Schmitt, M., Goretzki, L., Chucholowski, N., Calvete, J., Kramer, M., Günzler, W.A., Jänicke, F., Graeff, H. J. Biol. Chem. (1991)
- Sphingosine kinase-1 is cleaved by cathepsin B in vitro: Identification of the initial cleavage sites for the protease. Taha, T.A., El-Alwani, M., Hannun, Y.A., Obeid, L.M. FEBS Lett. (2006)
- Amyloid beta/A4 precursor protein (APP) processing in lysosomes. Tagawa, K., Maruyama, K., Ishiura, S. Ann. N. Y. Acad. Sci. (1992)
- The role of extracellular matrix in the processing of the amyloid protein precursor of Alzheimer's disease. Small, D.H., Nurcombe, V., Clarris, H., Beyreuther, K., Masters, C.L. Ann. N. Y. Acad. Sci. (1993)
- Cytochemical localization of hyaluronic acid in human synovium with special reference to its possible process of degradation. Asari, A., Kuriyama, S., Kominami, E., Uchiyama, Y. Arch. Histol. Cytol. (1995)
- Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. Griffiths, G.M., Isaaz, S. J. Cell Biol. (1993)
- Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells. Cavallo-Medved, D., Dosescu, J., Linebaugh, B.E., Sameni, M., Rudy, D., Sloane, B.F. Neoplasia (2003)
- Abnormal cathepsin B activity in Batten disease. Dawson, G., Glaser, P.T. American journal of medical genetics. Supplement. (1988)
- OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Yacoub, A., Park, M.A., Hanna, D., Hong, Y., Mitchell, C., Pandya, A.P., Harada, H., Powis, G., Chen, C.S., Koumenis, C., Grant, S., Dent, P. Mol. Pharmacol. (2006)
- Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B. Guo, M., Mathieu, P.A., Linebaugh, B., Sloane, B.F., Reiners, J.J. J. Biol. Chem. (2002)
- Degradation of laminin by human tumor cathepsin B. Lah, T.T., Buck, M.R., Honn, K.V., Crissman, J.D., Rao, N.C., Liotta, L.A., Sloane, B.F. Clin. Exp. Metastasis (1989)
- Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells. Mai, J., Finley, R.L., Waisman, D.M., Sloane, B.F. J. Biol. Chem. (2000)
- Insulin-like growth factor II receptor-mediated intracellular retention of cathepsin B is essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus. Rose, P.P., Bogyo, M., Moses, A.V., Früh, K. J. Virol. (2007)
- Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1). Riccio, M., Di Giaimo, R., Pianetti, S., Palmieri, P.P., Melli, M., Santi, S. Exp. Cell Res. (2001)