Gene Review:
Hc - hemolytic complement
Mus musculus
Synonyms:
C5, C5a, Complement C5, He, Hemolytic complement
- Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Hillebrandt, S., Wasmuth, H.E., Weiskirchen, R., Hellerbrand, C., Keppeler, H., Werth, A., Schirin-Sokhan, R., Wilkens, G., Geier, A., Lorenzen, J., Köhl, J., Gressner, A.M., Matern, S., Lammert, F. Nat. Genet. (2005)
- Genetic control of resistance to Listeria monocytogenes: regulation of leukocyte inflammatory responses by the Hc locus. Gervais, F., Stevenson, M., Skamene, E. J. Immunol. (1984)
- Tumor necrosis factor/cachectin. Induction of hemorrhagic necrosis in normal tissue requires the fifth component of complement (C5). Rothstein, J.L., Lint, T.F., Schreiber, H. J. Exp. Med. (1988)
- An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization. Lambrecht, B.N. J. Clin. Invest. (2006)
- Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. Girardi, G., Berman, J., Redecha, P., Spruce, L., Thurman, J.M., Kraus, D., Hollmann, T.J., Casali, P., Caroll, M.C., Wetsel, R.A., Lambris, J.D., Holers, V.M., Salmon, J.E. J. Clin. Invest. (2003)
- The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease. Mukherjee, P., Pasinetti, G.M. J. Neuroimmunol. (2000)
- A role of Ia-associated invariant chains in antigen processing and presentation. Stockinger, B., Pessara, U., Lin, R.H., Habicht, J., Grez, M., Koch, N. Cell (1989)
- Increased expression of an adhesion-promoting surface glycoprotein in the granulocytopenia of hemodialysis. Arnaout, M.A., Hakim, R.M., Todd, R.F., Dana, N., Colten, H.R. N. Engl. J. Med. (1985)
- Generation of C5a in the absence of C3: a new complement activation pathway. Huber-Lang, M., Sarma, J.V., Zetoune, F.S., Rittirsch, D., Neff, T.A., McGuire, S.R., Lambris, J.D., Warner, R.L., Flierl, M.A., Hoesel, L.M., Gebhard, F., Younger, J.G., Drouin, S.M., Wetsel, R.A., Ward, P.A. Nat. Med. (2006)
- Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice. Mahesh, J., Daly, J., Cheadle, W.G., Kotwal, G.J. Shock (1999)
- Development of dextran sulfate sodium-induced colitis is aggravated in mice genetically deficient for complement C5. Deguchi, Y., Andoh, A., Inatomi, O., Araki, Y., Hata, K., Tsujikawa, T., Kitoh, K., Fujiyama, Y. Int. J. Mol. Med. (2005)
- Identification of a potent and orally active non-peptide C5a receptor antagonist. Sumichika, H., Sakata, K., Sato, N., Takeshita, S., Ishibuchi, S., Nakamura, M., Kamahori, T., Ehara, S., Itoh, K., Ohtsuka, T., Ohbora, T., Mishina, T., Komatsu, H., Naka, Y. J. Biol. Chem. (2002)
- A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, peritonitis, and cytokine production in vivo. Vlasenko, L.P., Melendez, A.J. J. Immunol. (2005)
- Regulation of heme biosynthesis in Escherichia coli. Woodard, S.I., Dailey, H.A. Arch. Biochem. Biophys. (1995)
- Chromosomal location of the genes encoding complement components C5 and factor H in the mouse. D'Eustachio, P., Kristensen, T., Wetsel, R.A., Riblet, R., Taylor, B.A., Tack, B.F. J. Immunol. (1986)
- The proinflammatory mediators C3a and C5a are essential for liver regeneration. Strey, C.W., Markiewski, M., Mastellos, D., Tudoran, R., Spruce, L.A., Greenbaum, L.E., Lambris, J.D. J. Exp. Med. (2003)
- Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice. Kumar, V., Ali, S.R., Konrad, S., Zwirner, J., Verbeek, J.S., Schmidt, R.E., Gessner, J.E. J. Clin. Invest. (2006)
- Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment. Tsuji, R.F., Kawikova, I., Ramabhadran, R., Akahira-Azuma, M., Taub, D., Hugli, T.E., Gerard, C., Askenase, P.W. J. Immunol. (2000)
- Genetic defect in secretion of complement C5 in mice. Ooi, Y.M., Colten, H.R. Nature (1979)
- A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. Köhl, J., Baelder, R., Lewkowich, I.P., Pandey, M.K., Hawlisch, H., Wang, L., Best, J., Herman, N.S., Sproles, A.A., Zwirner, J., Whitsett, J.A., Gerard, C., Sfyroera, G., Lambris, J.D., Wills-Karp, M. J. Clin. Invest. (2006)
- Drusen complement components C3a and C5a promote choroidal neovascularization. Nozaki, M., Raisler, B.J., Sakurai, E., Sarma, J.V., Barnum, S.R., Lambris, J.D., Chen, Y., Zhang, K., Ambati, B.K., Baffi, J.Z., Ambati, J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Mouse complement component C4 is devoid of classical pathway C5 convertase subunit activity. Ebanks, R.O., Isenman, D.E. Mol. Immunol. (1996)
- Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. Borders, C.W., Courtney, A., Ronen, K., Pilar Laborde-Lahoz, M., Guidry, T.V., Hwang, S.A., Olsen, M., Hunter, R.L., Hollmann, T.J., Wetsel, R.A., Actor, J.K. Scand. J. Immunol. (2005)
- Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage. Fung, M., Lu, M., Fure, H., Sun, W., Sun, C., Shi, N.Y., Dou, Y., Su, J., Swanson, X., Mollnes, T.E. Clin. Exp. Immunol. (2003)
- Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung. Haviland, D.L., McCoy, R.L., Whitehead, W.T., Akama, H., Molmenti, E.P., Brown, A., Haviland, J.C., Parks, W.C., Perlmutter, D.H., Wetsel, R.A. J. Immunol. (1995)
- NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells. Hsu, M.H., Wang, M., Browning, D.D., Mukaida, N., Ye, R.D. Blood (1999)
- The differential role of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase in eosinophil functions. Adachi, T., Choudhury, B.K., Stafford, S., Sur, S., Alam, R. J. Immunol. (2000)
- C5a negatively regulates toll-like receptor 4-induced immune responses. Hawlisch, H., Belkaid, Y., Baelder, R., Hildeman, D., Gerard, C., Köhl, J. Immunity (2005)
- C5a-mediated leukotriene B4-amplified neutrophil chemotaxis is essential in tumor immunotherapy facilitated by anti-tumor monoclonal antibody and beta-glucan. Allendorf, D.J., Yan, J., Ross, G.D., Hansen, R.D., Baran, J.T., Subbarao, K., Wang, L., Haribabu, B. J. Immunol. (2005)
- C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease. Shushakova, N., Skokowa, J., Schulman, J., Baumann, U., Zwirner, J., Schmidt, R.E., Gessner, J.E. J. Clin. Invest. (2002)
- Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. Segal, B.H., Kuhns, D.B., Ding, L., Gallin, J.I., Holland, S.M. J. Leukoc. Biol. (2002)
- Assignment of the structural gene for argininosuccinate synthetase to proximal mouse chromosome 2. Jackson, M.J., Surh, L.C., O'Brien, W.E., Beaudet, A.L. Genomics (1990)
- A role for complement in antibody-mediated inflammation: C5-deficient DBA/1 mice are resistant to collagen-induced arthritis. Wang, Y., Kristan, J., Hao, L., Lenkoski, C.S., Shen, Y., Matis, L.A. J. Immunol. (2000)
- ApoE(-/-) mice develop atherosclerosis in the absence of complement component C5. Patel, S., Thelander, E.M., Hernandez, M., Montenegro, J., Hassing, H., Burton, C., Mundt, S., Hermanowski-Vosatka, A., Wright, S.D., Chao, Y.S., Detmers, P.A. Biochem. Biophys. Res. Commun. (2001)
- The complement component C5 of the common carp (Cyprinus carpio): cDNA cloning of two distinct isotypes that differ in a functional site. Kato, Y., Nakao, M., Mutsuro, J., Zarkadis, I.K., Yano, T. Immunogenetics (2003)
- Studies on the polymorphism of the fifth component of complement in laboratory mice. Lynch, D.M., Kay, P.H. Exp. Clin. Immunogenet. (1995)