Gene Review:
Hgs - HGF-regulated tyrosine kinase substrate
Mus musculus
Synonyms:
Hepatocyte growth factor-regulated tyrosine kinase substrate, Hgr, Hrs, ZFYVE8
- Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Komada, M., Kitamura, N. Mol. Cell. Biol. (1995)
- Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria. Vieira, O.V., Harrison, R.E., Scott, C.C., Stenmark, H., Alexander, D., Liu, J., Gruenberg, J., Schreiber, A.D., Grinstein, S. Mol. Cell. Biol. (2004)
- Mercury-resistant plasmids in bacteria from a mercury and antimony deposit area. Khesin, R.B., Karasyova, E.V. Mol. Gen. Genet. (1984)
- Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Komada, M., Soriano, P. Genes Dev. (1999)
- Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Abella, J.V., Peschard, P., Naujokas, M.A., Lin, T., Saucier, C., Urbé, S., Park, M. Mol. Cell. Biol. (2005)
- A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors. Takata, H., Kato, M., Denda, K., Kitamura, N. Genes Cells (2000)
- Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation. Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., Sugamura, K. Biochem. Biophys. Res. Commun. (2003)
- Galactosylceramide expression factor-1 induces myogenesis in MDCK and C3H10T1/2 cells. Ogura, K., Niino, Y.S., Tai, T. Arch. Biochem. Biophys. (2004)
- Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1. Sasaki, Y., Sugamura, K. J. Biol. Chem. (2001)
- Molecular cloning and characterization of galactosylceramide expression factor-1 (GEF-1). Ogura, K., Tai, T. Neurochem. Res. (2002)
- Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Miura, S., Takeshita, T., Asao, H., Kimura, Y., Murata, K., Sasaki, Y., Hanai, J.I., Beppu, H., Tsukazaki, T., Wrana, J.L., Miyazono, K., Sugamura, K. Mol. Cell. Biol. (2000)
- Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Raiborg, C., Bache, K.G., Gillooly, D.J., Madshus, I.H., Stang, E., Stenmark, H. Nat. Cell Biol. (2002)