Gene Review:
Hoxd13 - homeobox D13
Mus musculus
Synonyms:
Homeobox protein Hox-4.8, Homeobox protein Hox-D13, Hox-4.8, spdh
- The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Albrecht, A.N., Schwabe, G.C., Stricker, S., Böddrich, A., Wanker, E.E., Mundlos, S. Mech. Dev. (2002)
- Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13. Podlasek, C.A., Duboule, D., Bushman, W. Dev. Dyn. (1997)
- The molecular basis of hypodactyly (Hd): a deletion in Hoxa 13 leads to arrest of digital arch formation. Mortlock, D.P., Post, L.C., Innis, J.W. Nat. Genet. (1996)
- Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Dollé, P., Dierich, A., LeMeur, M., Schimmang, T., Schuhbaur, B., Chambon, P., Duboule, D. Cell (1993)
- Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Zákány, J., Duboule, D. Nature (1996)
- Hox gene expression in teleost fins and the origin of vertebrate digits. Sordino, P., van der Hoeven, F., Duboule, D. Nature (1995)
- Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex. Kmita, M., van Der Hoeven, F., Zákány, J., Krumlauf, R., Duboule, D. Genes Dev. (2000)
- The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' HoxD genes during limb pattern formation. Haramis, A.G., Brown, J.M., Zeller, R. Development (1995)
- Suppression of polydactyly of the Gli3 mutant (extra toes) by deltaEF1 homozygous mutation. Moribe, H., Takagi, T., Kondoh, H., Higashi, Y. Dev. Growth Differ. (2000)
- All for one and one for all: condensations and the initiation of skeletal development. Hall, B.K., Miyake, T. Bioessays (2000)
- Effects of all-trans-retinoic acid on skeletal pattern, 5'HoxD gene expression, and RAR beta 2/beta 4 promoter activity in embryonic mouse limbs. Wood, H.B., Ward, S.J., Morriss-Kay, G.M. Dev. Genet. (1996)
- The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb. Ros, M.A., Dahn, R.D., Fernandez-Teran, M., Rashka, K., Caruccio, N.C., Hasso, S.M., Bitgood, J.J., Lancman, J.J., Fallon, J.F. Development (2003)
- Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod. Boulet, A.M., Capecchi, M.R. Development (2004)
- Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. de la Cruz, C.C., Der-Avakian, A., Spyropoulos, D.D., Tieu, D.D., Carpenter, E.M. Dev. Biol. (1999)
- Altered Hox expression and increased cell death distinguish Hypodactyly from Hoxa13 null mice. Post, L.C., Innis, J.W. Int. J. Dev. Biol. (1999)
- A new spontaneous mouse mutation of Hoxd13 with a polyalanine expansion and phenotype similar to human synpolydactyly. Johnson, K.R., Sweet, H.O., Donahue, L.R., Ward-Bailey, P., Bronson, R.T., Davisson, M.T. Hum. Mol. Genet. (1998)
- Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. Francis, P.H., Richardson, M.K., Brickell, P.M., Tickle, C. Development (1994)
- Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis. Kuss, P., Villavicencio-Lorini, P., Witte, F., Klose, J., Albrecht, A.N., Seemann, P., Hecht, J., Mundlos, S. J. Clin. Invest. (2009)
- The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development. Dollé, P., Izpisúa-Belmonte, J.C., Boncinelli, E., Duboule, D. Mech. Dev. (1991)
- Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation, duplication, and posterior transformation of digit in mouse limb. Zhang, Z., Yu, X., Zhang, Y., Geronimo, B., Lovlie, A., Fromm, S.H., Chen, Y. Dev. Biol. (2000)
- Some distal limb structures develop in mice lacking Sonic hedgehog signaling. Kraus, P., Fraidenraich, D., Loomis, C.A. Mech. Dev. (2001)
- An enhancer-titration effect induces digit-specific regulatory alleles of the HoxD cluster. Monge, I., Kondo, T., Duboule, D. Dev. Biol. (2003)
- Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. Hérault, Y., Hraba-Renevey, S., van der Hoeven, F., Duboule, D. EMBO J. (1996)
- Hox proteins functionally cooperate with the GC box-binding protein system through distinct domains. Suzuki, M., Ueno, N., Kuroiwa, A. J. Biol. Chem. (2003)
- Polarizing activity, Sonic hedgehog, and tooth development in embryonic and postnatal mouse. Koyama, E., Yamaai, T., Iseki, S., Ohuchi, H., Nohno, T., Yoshioka, H., Hayashi, Y., Leatherman, J.L., Golden, E.B., Noji, S., Pacifici, M. Dev. Dyn. (1996)
- Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts. Warot, X., Fromental-Ramain, C., Fraulob, V., Chambon, P., Dollé, P. Development (1997)