Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Ifit2 - interferon-induced protein with...

Mus musculus

Synonyms: AV302338, GARG-39, Garg39, Glucocorticoid-attenuated response gene 39 protein, IFI-54K, ...

Saha, S. et al., Bluyssen, H.A. et al., Aung, H.T. et al.

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Disease relevance of Ifit2

While GARG39 was known for a long time as an inflammation-inducible glucocorticoid attenuated protein, its identification as a microtubule-associated protein in this study suggests a possible role for this protein in cell proliferation, virion assembly/transport and microtubule dynamics [1].
Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein [1].

High impact information on Ifit2

It was demonstrated that GARG39 protein interacts with microtubules in vitro, co-localizes with beta-tubulin in vivo and is enriched in the mitotic spindle of non-neuronal cells undergoing mitosis [1].
Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family [2].
It turned out that ISRE 2 is hardly active, due to the G at position 4, which is a T in the hamster Ifi54 ISRE 2 and in the ISRE consensus sequence [2].
The Ifi54 promoter region contains two sequences, which are closely related to the interferon stimulated response element (ISRE) consensus sequence (ISRE 1, GGTTTCAATTTCT, and ISRE 2, AGTGTTACTTTCT) [2].
Treatment of BMM with trichostatin A (TSA), an inhibitor of HDACs, enhanced LPS-induced expression of the Cox-2, Cxcl2, and Ifit2 genes [3].

References

Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein. Saha, S., Sugumar, P., Bhandari, P., Rangarajan, P.N. J. Gen. Virol. (2006) [Pubmed]
Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family. Bluyssen, H.A., Vlietstra, R.J., Faber, P.W., Smit, E.M., Hagemeijer, A., Trapman, J. Genomics (1994) [Pubmed]
LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. Aung, H.T., Schroder, K., Himes, S.R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D.A., Sweet, M.J., Ravasi, T. FASEB J. (2006) [Pubmed]

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