Gene Review:
Igf1 - insulin-like growth factor 1
Mus musculus
Synonyms:
C730016P09Rik, IGF-I, Igf-1, Igf-I, Insulin-like growth factor I, ...
Shih,
Kulkarni,
Diaz-Casares,
Berho,
Varela-Nieto,
Gill,
Sindelar,
Morales-Garcia,
Sánchez-Galiano,
Pereria-Simon,
Holzenberger,
Ozcan,
Gorospe,
Contreras,
Yee,
Sampat,
Aplin,
Bergman,
Wang,
Bievre,
Elliot,
Li,
Bondy,
Gibson,
Cañon,
Striker,
Lewitt,
Bobek,
Osborne,
Brismar,
Westwood,
Magnuson,
Hilsenbeck,
Cediel,
Zakari,
Leon,
Xia,
Gooch,
Hu,
Zhou,
Yuspa,
Jackson,
Kahn,
Camarero,
Vigil,
White,
Gonzalez,
Stoffel,
Espinosa-Heidmann,
Wivall-Helleryd,
Karl,
Lee,
Collinge,
Coronado-Heinsohn,
- Igf1 promotes longitudinal bone growth by insulin-like actions augmenting chondrocyte hypertrophy. Wang, J., Zhou, J., Bondy, C.A. FASEB J. (1999)
- Effects of Igf1 gene deletion on postnatal growth patterns. Wang, J., Zhou, J., Powell-Braxton, L., Bondy, C. Endocrinology (1999)
- Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Sell, C., Rubini, M., Rubin, R., Liu, J.P., Efstratiadis, A., Baserga, R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Insulin-like growth factor I is a dual effector of multiple myeloma cell growth. Ge, N.L., Rudikoff, S. Blood (2000)
- Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease. Lopez-Lopez, C., Dietrich, M.O., Metzger, F., Loetscher, H., Torres-Aleman, I. J. Neurosci. (2007)
- Akt is altered in an animal model of Huntington's disease and in patients. Colin, E., Régulier, E., Perrin, V., Dürr, A., Brice, A., Aebischer, P., Déglon, N., Humbert, S., Saudou, F. Eur. J. Neurosci. (2005)
- Liver-derived IGF-I regulates exploratory activity in old mice. Svensson, J., Söderpalm, B., Sjögren, K., Engel, J., Ohlsson, C. Am. J. Physiol. Endocrinol. Metab. (2005)
- Neuroprotective effects of IGF-I against TNFalpha-induced neuronal damage in HIV-associated dementia. Ying Wang, J., Peruzzi, F., Lassak, A., Del Valle, L., Radhakrishnan, S., Rappaport, J., Khalili, K., Amini, S., Reiss, K. Virology (2003)
- Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear. Varela-Nieto, I., Morales-Garcia, J.A., Vigil, P., Diaz-Casares, A., Gorospe, I., Sánchez-Galiano, S., Cañon, S., Camarero, G., Contreras, J., Cediel, R., Leon, Y. Hear. Res. (2004)
- beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Kulkarni, R.N., Holzenberger, M., Shih, D.Q., Ozcan, U., Stoffel, M., Magnuson, M.A., Kahn, C.R. Nat. Genet. (2002)
- Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Musarò, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., Barton, E.R., Sweeney, H.L., Rosenthal, N. Nat. Genet. (2001)
- Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Withers, D.J., Burks, D.J., Towery, H.H., Altamuro, S.L., Flint, C.L., White, M.F. Nat. Genet. (1999)
- Castration-induced apoptosis of androgen-dependent shionogi carcinoma is associated with increased expression of genes encoding insulin-like growth factor-binding proteins. Nickerson, T., Miyake, H., Gleave, M.E., Pollak, M. Cancer Res. (1999)
- Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. Lee, A.V., Jackson, J.G., Gooch, J.L., Hilsenbeck, S.G., Coronado-Heinsohn, E., Osborne, C.K., Yee, D. Mol. Endocrinol. (1999)
- Increased expression of platelet-derived growth factor A and insulin-like growth factor-I in BAL cells during the development of bleomycin-induced pulmonary fibrosis in mice. Maeda, A., Hiyama, K., Yamakido, H., Ishioka, S., Yamakido, M. Chest (1996)
- Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two beta subunits are derived from differences in glycosylation. Ota, A., Wilson, G.L., Leroith, D. Eur. J. Biochem. (1988)
- Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination. Komoly, S., Hudson, L.D., Webster, H.D., Bondy, C.A. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle. Adesanya, O.O., Zhou, J., Samathanam, C., Powell-Braxton, L., Bondy, C.A. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. Kido, Y., Nakae, J., Hribal, M.L., Xuan, S., Efstratiadis, A., Accili, D. J. Biol. Chem. (2002)
- Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition. Cheng, C.M., Joncas, G., Reinhardt, R.R., Farrer, R., Quarles, R., Janssen, J., McDonald, M.P., Crawley, J.N., Powell-Braxton, L., Bondy, C.A. J. Neurosci. (1998)
- Postnatally Elevated Levels of Insulin-Like Growth Factor (IGF)-II Fail to Rescue the Dwarfism of IGF-I-Deficient Mice except Kidney Weight. Moerth, C., Schneider, M.R., Renner-Mueller, I., Blutke, A., Elmlinger, M.W., Erben, R.G., Camacho-H??bner, C., Hoeflich, A., Wolf, E. Endocrinology (2007)
- Insulin-like growth factor 1 is essential for normal dendritic growth. Cheng, C.M., Mervis, R.F., Niu, S.L., Salem, N., Witters, L.A., Tseng, V., Reinhardt, R., Bondy, C.A. J. Neurosci. Res. (2003)
- Reduced GLUT1 expression in Igf1-/- null oocytes and follicles. Zhou, J., Bievre, M., Bondy, C.A. Growth Horm. IGF Res. (2000)
- PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons. Delcourt, N., Thouvenot, E., Chanrion, B., Galéotti, N., Jouin, P., Bockaert, J., Marin, P. EMBO J. (2007)
- Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. Schertzer, J.D., Gehrig, S.M., Ryall, J.G., Lynch, G.S. Am. J. Pathol. (2007)
- Glucagon-like peptide-2 activates beta-catenin signaling in the mouse intestinal crypt: role of insulin-like growth factor-I. Dubé, P.E., Rowland, K.J., Brubaker, P.L. Endocrinology (2008)
- An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I. Elgin, R.G., Busby, W.H., Clemmons, D.R. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR. Denley, A., Bonython, E.R., Booker, G.W., Cosgrove, L.J., Forbes, B.E., Ward, C.W., Wallace, J.C. Mol. Endocrinol. (2004)
- Gene expression of the insulin-like growth factor system during mouse kidney development. Lindenbergh-Kortleve, D.J., Rosato, R.R., van Neck, J.W., Nauta, J., van Kleffens, M., Groffen, C., Zwarthoff, E.C., Drop, S.L. Mol. Cell. Endocrinol. (1997)
- Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice. Lewitt, M.S., Brismar, K., Wang, J., Wivall-Helleryd, I.L., Sindelar, P., Gonzalez, F.J., Bergman, T., Bobek, G.A. Growth Horm. IGF Res. (2001)
- Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes. Chen, W., Salojin, K.V., Mi, Q.S., Grattan, M., Meagher, T.C., Zucker, P., Delovitch, T.L. Endocrinology (2004)
- Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Araki, E., Lipes, M.A., Patti, M.E., Brüning, J.C., Haag, B., Johnson, R.S., Kahn, C.R. Nature (1994)
- The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling. Beitner-Johnson, D., Blakesley, V.A., Shen-Orr, Z., Jimenez, M., Stannard, B., Wang, L.M., Pierce, J., LeRoith, D. J. Biol. Chem. (1996)
- Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src. Peterson, J.E., Kulik, G., Jelinek, T., Reuter, C.W., Shannon, J.A., Weber, M.J. J. Biol. Chem. (1996)
- alpha 2-Macroglobulin: a new component in the insulin-like growth factor/insulin-like growth factor binding protein-1 axis. Westwood, M., Aplin, J.D., Collinge, I.A., Gill, A., White, A., Gibson, J.M. J. Biol. Chem. (2001)
- Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I. Entingh-Pearsall, A., Kahn, C.R. J. Biol. Chem. (2004)
- Nuclear translocation of insulin receptor substrate-1 by oncogenes and Igf-I. Effect on ribosomal RNA synthesis. Tu, X., Batta, P., Innocent, N., Prisco, M., Casaburi, I., Belletti, B., Baserga, R. J. Biol. Chem. (2002)
- Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. Li, L., Sampat, K., Hu, N., Zakari, J., Yuspa, S.H. J. Biol. Chem. (2006)
- Smoking Induces Glomerulosclerosis in Aging Estrogen-Deficient Mice through Cross-Talk between TGF-beta1 and IGF-I Signaling Pathways. Elliot, S.J., Karl, M., Berho, M., Xia, X., Pereria-Simon, S., Espinosa-Heidmann, D., Striker, G.E. J. Am. Soc. Nephrol. (2006)
- Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors. Paria, B.C., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Involvement of transforming growth factor beta1 in autocrine enhancement of gelatinase B secretion by murine metastatic colon carcinoma cells. Shimizu, S., Nishikawa, Y., Kuroda, K., Takagi, S., Kozaki, K., Hyuga, S., Saga, S., Matsuyama, M. Cancer Res. (1996)
- Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. Xu, J., Liao, K. J. Biol. Chem. (2004)
- Growth hormone-releasing hormone antagonist MZ-5-156 inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of insulin-like growth factor II in tumors. Lamharzi, N., Schally, A.V., Koppán, M., Groot, K. Proc. Natl. Acad. Sci. U.S.A. (1998)
- The insulin-like growth factor axis and prostate cancer: lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Kaplan, P.J., Mohan, S., Cohen, P., Foster, B.A., Greenberg, N.M. Cancer Res. (1999)
- Tumor necrosis factor alpha inhibits transcriptional activity of the porcine P-45011A insulin-like growth factor response element. Urban, R.J., Nagamani, M., Bodenburg, Y. J. Biol. Chem. (1996)
- Impact of androgens, growth hormone, and igf-I on bone and muscle in male mice during puberty. Venken, K., Mov??rare-Skrtic, S., Kopchick, J.J., Coschigano, K.T., Ohlsson, C., Boonen, S., Bouillon, R., Vanderschueren, D. J. Bone Miner. Res. (2007)