Gene Review:
Igfbp3 - insulin-like growth factor binding protein 3
Mus musculus
Synonyms:
AI649005, IBP-3, IGF-binding protein 3, IGFBP-3, IGgfbp3, ...
- Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Takaoka, M., Harada, H., Andl, C.D., Oyama, K., Naomoto, Y., Dempsey, K.L., Klein-Szanto, A.J., El-Deiry, W.S., Grimberg, A., Nakagawa, H. Cancer Res. (2004)
- Perturbations in bone formation and resorption in insulin-like growth factor binding protein-3 transgenic mice. Silha, J.V., Mishra, S., Rosen, C.J., Beamer, W.G., Turner, R.T., Powell, D.R., Murphy, L.J. J. Bone Miner. Res. (2003)
- Serum insulin-like growth factor binding protein-3 in the hypophosphatemic mouse: decreased activity and abnormal modulation by dietary phosphate. Moriwake, T., Abribat, T., Brazeau, P., Ecarot, B. J. Bone Miner. Res. (1995)
- Cellular actions of the insulin-like growth factor binding proteins. Firth, S.M., Baxter, R.C. Endocr. Rev. (2002)
- Circulating levels of IGF-1 directly regulate bone growth and density. Yakar, S., Rosen, C.J., Beamer, W.G., Ackert-Bicknell, C.L., Wu, Y., Liu, J.L., Ooi, G.T., Setser, J., Frystyk, J., Boisclair, Y.R., LeRoith, D. J. Clin. Invest. (2002)
- Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. Neuenschwander, S., Schwartz, A., Wood, T.L., Roberts, C.T., Hennighausen, L., LeRoith, D. J. Clin. Invest. (1996)
- Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I. Ohneda, K., Ulshen, M.H., Fuller, C.R., D'Ercole, A.J., Lund, P.K. Gastroenterology (1997)
- Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer. Adhami, V.M., Siddiqui, I.A., Ahmad, N., Gupta, S., Mukhtar, H. Cancer Res. (2004)
- Inhibitory effect of a growth hormone receptor antagonist (G120K-PEG) on renal enlargement, glomerular hypertrophy, and urinary albumin excretion in experimental diabetes in mice. Flyvbjerg, A., Bennett, W.F., Rasch, R., Kopchick, J.J., Scarlett, J.A. Diabetes (1999)
- Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo. Liu, B., Lee, K.W., Li, H., Ma, L., Lin, G.L., Chandraratna, R.A., Cohen, P. Clin. Cancer Res. (2005)
- Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice. Donahue, L.R., Watson, G., Beamer, W.G. J. Endocrinol. (1993)
- In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. Singh, R.P., Sharma, G., Mallikarjuna, G.U., Dhanalakshmi, S., Agarwal, C., Agarwal, R. Clin. Cancer Res. (2004)
- Igfbp3 modulates cell proliferation in the hair follicle. Weger, N., Schlake, T. J. Invest. Dermatol. (2005)
- Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. Lee, K.W., Ma, L., Yan, X., Liu, B., Zhang, X.K., Cohen, P. J. Biol. Chem. (2005)
- Involvement of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in corneal fibroblasts during corneal wound healing. Izumi, K., Kurosaka, D., Iwata, T., Oguchi, Y., Tanaka, Y., Mashima, Y., Tsubota, K. Invest. Ophthalmol. Vis. Sci. (2006)
- Castration rapidly decreases local insulin-like growth factor-1 levels and inhibits its effects in the ventral prostate in mice. Ohlson, N., Bergh, A., Persson, M.L., Wikstr??m, P. Prostate (2006)
- Expression of the insulin-like growth factor binding proteins during postnatal development of the murine mammary gland. Allar, M.A., Wood, T.L. Endocrinology (2004)
- Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. Wang, E., Wang, J., Chin, E., Zhou, J., Bondy, C.A. Endocrinology (1995)
- Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Ning, Y., Schuller, A.G., Bradshaw, S., Rotwein, P., Ludwig, T., Frystyk, J., Pintar, J.E. Mol. Endocrinol. (2006)
- Regulation of insulin-like growth factor binding protein secretion by a murine mammary epithelial cell line. Skaar, T.C., Baumrucker, C.R. Exp. Cell Res. (1993)
- Characterization of insulin-like growth factor binding proteins (IGFBPs) during gestation in mice: effects of hypophysectomy and an IGFBP-specific serum protease activity. Fielder, P.J., Thordarson, G., Talamantes, F., Rosenfeld, R.G. Endocrinology (1990)
- Insulin-Like growth factor I (IGF-I) and cyclic adenosine 3',5'-monophosphate regulate IGF-binding protein-3 gene expression by transcriptional and posttranscriptional mechanisms in mammary epithelial cells. Cohick, W.S., Wang, B., Verma, P., Boisclair, Y.R. Endocrinology (2000)
- Molecular recognition characteristics in the insulin-like growth factor (IGF)-insulin-like growth factor binding protein -3/5 (IGFBP-3/5) heparin axis. Beattie, J., Phillips, K., Shand, J.H., Szymanowska, M., Flint, D.J., Allan, G.J. J. Mol. Endocrinol. (2005)
- Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3. Iwatsuki, K., Tanaka, K., Kaneko, T., Kazama, R., Okamoto, S., Nakayama, Y., Ito, Y., Satake, M., Takahashi, S., Miyajima, A., Watanabe, T., Hara, T. Oncogene (2005)
- Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes. Chen, W., Salojin, K.V., Mi, Q.S., Grattan, M., Meagher, T.C., Zucker, P., Delovitch, T.L. Endocrinology (2004)
- Cloning and characterization of mouse klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity. Matsui, H., Moriyama, A., Takahashi, T. Eur. J. Biochem. (2000)
- Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability. Nakamura, M., Miyamoto, S., Maeda, H., Ishii, G., Hasebe, T., Chiba, T., Asaka, M., Ochiai, A. Biochem. Biophys. Res. Commun. (2005)
- Tissue-specific expression of the insulin-like growth factor binding protein (IGFBP) mRNAs in mouse and rat development. Cerro, J.A., Grewal, A., Wood, T.L., Pintar, J.E. Regul. Pept. (1993)
- Identification of insulin receptor substrate proteins as key molecules for the TbetaR-V/LRP-1-mediated growth inhibitory signaling cascade in epithelial and myeloid cells. Huang, S.S., Leal, S.M., Chen, C.L., Liu, I.H., Huang, J.S. FASEB J. (2004)
- A quantitative RT-PCR study of the mRNA expression profile of the IGF axis during mammary gland development. Boutinaud, M., Shand, J.H., Park, M.A., Phillips, K., Beattie, J., Flint, D.J., Allan, G.J. J. Mol. Endocrinol. (2004)
- Phenotypic manifestations of insulin-like growth factor-binding protein-3 overexpression in transgenic mice. Modric, T., Silha, J.V., Shi, Z., Gui, Y., Suwanichkul, A., Durham, S.K., Powell, D.R., Murphy, L.J. Endocrinology (2001)
- The 16-kDa proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 inhibits the mitogenic action of fibroblast growth factor on mouse fibroblasts with a targeted disruption of the type 1 IGF receptor gene. Zadeh, S.M., Binoux, M. Endocrinology (1997)
- Heparin-binding EGF-like growth factor (HB-EGF) overexpression in transgenic mice downregulates insulin-like growth factor binding protein (IGFBP)-3 and -4 mRNA. Provenzano, A.P., Besner, G.E., James, P.F., Harding, P.A. Growth Factors (2005)