High impact information on DCAL1

• The DCAL-1 locus is within a cluster of C-type lectin-like loci on human chromosome 12p12-13 just 3' to the CD69 locus [1].
• Coincubation with soluble DCAL-1 enhanced the proliferation of CD4(+) T cells in response to CD3 ligation and significantly increased IL-4 secretion [1].
• B cells also express high levels of DCAL-1 on their cell surface [1].
• DCAL-1 mRNA and protein expression are increased upon the differentiation of monocytes to CD1a(+) DCs [1].
• The consensus sequence of the DCAL-1 gene was confirmed by RACE-PCR; however, based on sequence alignment with genomic DNA and with various human expressed sequence tags, we predict that DCAL-1 has two splice variants [1].

Anatomical context of DCAL1

• Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4 [1].
• We have characterized dendritic cell (DC)-associated lectin-1 (DCAL-1), a novel, type II, transmembrane, C-type lectin-like protein [1].

Associations of DCAL1 with chemical compounds

• DCAL-1, however, is missing three of the cysteine residues required to form the standard carbohydrate recognition domain [1].

References