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Gene Review: 

Psmd9  -  proteasome (prosome, macropain) 26S...

Rattus norvegicus

Synonyms: 26S proteasome non-ATPase regulatory subunit 9, 26S proteasome regulatory subunit p27, Bridge, Bridge-1, Transactivating protein Bridge-1
 
 
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Disease relevance of Psmd9

  • Inactivation of endogenous Bridge-1 in insulinoma (INS-1) cells by expression of a Bridge-1 antisense RNA diminishes rat insulin I promoter activity [1].
 

High impact information on Psmd9

References

  1. Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. Thomas, M.K., Yao, K.M., Tenser, M.S., Wong, G.G., Habener, J.F. Mol. Cell. Biol. (1999) [Pubmed]
  2. Overexpression of the coactivator bridge-1 results in insulin deficiency and diabetes. Volinic, J.L., Lee, J.H., Eto, K., Kaur, V., Thomas, M.K. Mol. Endocrinol. (2006) [Pubmed]
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