Gene Review:
Il2rb - interleukin 2 receptor, beta chain
Mus musculus
Synonyms:
CD122, High affinity IL-2 receptor subunit beta, IL-15 receptor beta chain, IL-15Rbeta, IL-2 receptor subunit beta, ...
Nishimura,
Tagaya,
Tsunobuchi,
Suzuki,
Nakashima,
Yoshikai,
Walter,
Fassbender,
Gulbins,
Liu,
Rieschel,
Herten,
Bertsch,
Engelhardt,
- The action of interleukin-2 receptor subunits defines a new type of signaling mechanism for hematopoietin receptors in hepatic cells and fibroblasts. Morella, K.K., Lai, C.F., Kumaki, S., Kumaki, N., Wang, Y., Bluman, E.M., Witthuhn, B.A., Ihle, J.N., Giri, J., Gearing, D.P. J. Biol. Chem. (1995)
- Mice lacking interleukin-2 (IL-2)/IL-15 receptor beta chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant. Nishimura, H., Tagaya, M., Tsunobuchi, H., Suzuki, H., Nakashima, I., Yoshikai, Y. Infect. Immun. (2001)
- A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. Tsunobuchi, H., Nishimura, H., Goshima, F., Daikoku, T., Suzuki, H., Nakashima, I., Nishiyama, Y., Yoshikai, Y. Virology (2000)
- Molecular cloning of a partial cDNA of the interleukin-2 receptor-beta in normal mouse brain: in situ localization in the hippocampus and expression by neuroblastoma cells. Petitto, J.M., Huang, Z. Brain Res. (1994)
- Murine intracerebral interleukin-2 injection: pathological and immunological effects. Yamasaki, T., Kikuchi, H., Paine, J.T., Yamashita, J., Miyatake, S., Iwasaki, K., Kobayashi, H., Namba, Y., Hanaoka, M. J. Neurosurg. (1989)
- T cell anergy. Schwartz, R.H. Annu. Rev. Immunol. (2003)
- The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M., Takeshita, T. Annu. Rev. Immunol. (1996)
- The IL-2 receptor complex: its structure, function, and target genes. Minami, Y., Kono, T., Miyazaki, T., Taniguchi, T. Annu. Rev. Immunol. (1993)
- A restricted cytoplasmic region of IL-2 receptor beta chain is essential for growth signal transduction but not for ligand binding and internalization. Hatakeyama, M., Mori, H., Doi, T., Taniguchi, T. Cell (1989)
- Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Zhang, J., Cado, D., Chen, A., Kabra, N.H., Winoto, A. Nature (1998)
- Effects of pyocyanine, a blue pigment from Pseudomonas aeruginosa, on separate steps of T cell activation: interleukin 2 (IL 2) production, IL 2 receptor formation, proliferation and induction of cytolytic activity. Mühlradt, P.F., Tsai, H., Conradt, P. Eur. J. Immunol. (1986)
- Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex. Kimura, Y., Takeshita, T., Kondo, M., Ishii, N., Nakamura, M., Van Snick, J., Sugamura, K. Int. Immunol. (1995)
- The conversion of redox status of peritoneal macrophages during pathological progression of spontaneous inflammatory bowel disease in Janus family tyrosine kinase 3(-/-) and IL-2 receptor gamma(-/-) mice. Murata, Y., Yamashita, A., Saito, T., Sugamura, K., Hamuro, J. Int. Immunol. (2002)
- Glycosylation processing inhibition by castanospermine prevents experimental autoimmune encephalomyelitis by interference with IL-2 receptor signal transduction. Walter, S., Fassbender, K., Gulbins, E., Liu, Y., Rieschel, M., Herten, M., Bertsch, T., Engelhardt, B. J. Neuroimmunol. (2002)
- Testosterone receptor blockade restores cellular immunity in male mice after burn injury. Messingham, K.A., Messingham, K.A., Shirazi, M., Duffner, L.A., Duffner, L.A., Emanuele, M.A., Kovacs, E.J., Kovacs, E.J., Kovacs, E.J., Kovacs, E.J. J. Endocrinol. (2001)
- Biology of the interleukin-2 receptor. Nelson, B.H., Willerford, D.M. Adv. Immunol. (1998)
- Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Van Parijs, L., Refaeli, Y., Lord, J.D., Nelson, B.H., Abbas, A.K., Baltimore, D. Immunity (1999)
- Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells. Leclercq, G., Debacker, V., de Smedt, M., Plum, J. J. Exp. Med. (1996)
- Induction of interleukin 2 receptor beta chain expression by self-recognition in the thymus. Hanke, T., Mitnacht, R., Boyd, R., Hünig, T. J. Exp. Med. (1994)
- Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation. Nelson, B.H., Lord, J.D., Greenberg, P.D. Nature (1994)
- Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. Suzuki, H., Duncan, G.S., Takimoto, H., Mak, T.W. J. Exp. Med. (1997)
- Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Ravichandran, K.S., Igras, V., Shoelson, S.E., Fesik, S.W., Burakoff, S.J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain. Adachi, M., Sekiya, M., Torigoe, T., Takayama, S., Reed, J.C., Miyazaki, T., Minami, Y., Taniguchi, T., Imai, K. Blood (1996)
- Interleukin 2 responses of lpr and normal L3T4-/Lyt-2- T cells induced by TPA plus A23187. Katagiri, K., Katagiri, T., Eisenberg, R.A., Ting, J., Cohen, P.L. J. Immunol. (1987)
- The IL-2 receptor beta-chain (p70). Ligand binding ability of the cDNA-encoding membrane and secreted forms. Tsudo, M., Karasuyama, H., Kitamura, F., Tanaka, T., Kubo, S., Yamamura, Y., Tamatani, T., Hatakeyama, M., Taniguchi, T., Miyasaka, M. J. Immunol. (1990)
- Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line. Dornand, J., Bouaboula, M., d'Angeac, A.D., Favero, J., Shire, D., Casellas, P. J. Cell. Physiol. (1992)
- Receptor antagonist and selective agonist derivatives of mouse interleukin-2. Zurawski, S.M., Zurawski, G. EMBO J. (1992)
- Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Cheng, L.E., Ohlén, C., Nelson, B.H., Greenberg, P.D. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Unexpected effects of the IL-2 receptor alpha subunit on high affinity IL-2 receptor assembly and function detected with a mutant IL-2 analog. Kuziel, W.A., Ju, G., Grdina, T.A., Greene, W.C. J. Immunol. (1993)
- IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes. Casey, L.S., Lichtman, A.H., Boothby, M. J. Immunol. (1992)
- T cell activation in the absence of interleukin 2 (IL 2) results in the induction of high-affinity IL 2 receptor unable to transmit a proliferative signal. Proust, J.J., Shaper, N.L., Buchholz, M.A., Nordin, A.A. Eur. J. Immunol. (1991)
- Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor beta chain-deficient mice. Suzuki, H., Hayakawa, A., Bouchard, D., Nakashima, I., Mak, T.W. Int. Immunol. (1997)
- An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. Nakajima, H., Liu, X.W., Wynshaw-Boris, A., Rosenthal, L.A., Imada, K., Finbloom, D.S., Hennighausen, L., Leonard, W.J. Immunity (1997)
- IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor alpha chain. Wang, H.Y., Paul, W.E., Keegan, A.D. Immunity (1996)
- Role and regulation of interleukin (IL)-2 receptor alpha and beta chains in IL-2-driven B-cell growth. Nakanishi, K., Hirose, S., Yoshimoto, T., Ishizashi, H., Hiroishi, K., Tanaka, T., Kono, T., Miyasaka, M., Taniguchi, T., Higashino, K. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission. Fujii, H., Nakagawa, Y., Schindler, U., Kawahara, A., Mori, H., Gouilleux, F., Groner, B., Ihle, J.N., Minami, Y., Miyazaki, T. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo. Suzuki, H., Zhou, Y.W., Kato, M., Mak, T.W., Nakashima, I. J. Exp. Med. (1999)
- In vivo and in vitro expression of an interleukin 2 receptor by murine B and T lymphocytes. Finkelman, F.D., Malek, T.R., Shevach, E.M., Mond, J.J. J. Immunol. (1986)
- Lack of intermediate-affinity interleukin-2 receptor in mice leads to dependence on interleukin-2 receptor alpha, beta and gamma chain expression for T cell growth. Chastagner, P., Moreau, J.L., Jacques, Y., Tanaka, T., Miyasaka, M., Kondo, M., Sugamura, K., Thèze, J. Eur. J. Immunol. (1996)
- Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor. Gouilleux, F., Moritz, D., Humar, M., Moriggl, R., Berchtold, S., Groner, B. Endocrinology (1995)