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CITED4  -  Cbp/p300-interacting transactivator, with...

Homo sapiens

Synonyms: Cbp/p300-interacting transactivator 4, MRG-2, MRG2, MSG1-related protein 2
 
 
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Disease relevance of CITED4

  • To explore the function of CITED4 in breast cancer, we determined its expression in normal, in situ and invasive breast cancers [1].
  • In line with the latter finding, treatment of CITED4 hypermethylated glioma cell lines with 5-aza-2'-deoxycytidine and trichostatine A resulted in a marked increase of the CITED4 transcript levels [2].
 

High impact information on CITED4

  • CITED4, a recently identified member of the CITED family, binds p300/CBP via the CH1 domain and functions as a coactivator for transcription factor AP-2 [1].
  • CITED4 showed no significant correlation with patient age (P = 0.45), estrogen receptor (P = 0.11), or epidermal growth factor receptor (P = 0.48) [1].
  • Here, we show that CITED4 blocks the binding of hypoxia-inducible factor 1alpha to p300 in vitro and inhibits hypoxia-inducible factor-1alpha transactivation and hypoxia-mediated reporter gene activation [1].
  • In HepG2 cells, CITED4 is significantly weaker than CITED2 for TFAP2C co-activation [3].
  • CITED4 physically interacts with all TFAP2 isoforms in vitro and strongly co-activates all TFAP2 isoforms in Hep3B cells [3].
 

Biological context of CITED4

  • Here we describe human CITED4, a new member of this family, which is encoded by a single exon mapping to chromosome 1p34--1p35 [3].
 

Other interactions of CITED4

  • These results suggest that CITED4 may function as a co-activator for TFAP2 [3].
  • CITED4 and p300/CREB-binding protein are present in endogenous naturally occurring complexes, indicating that they interact physiologically [3].

References

  1. CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha. Fox, S.B., Bragança, J., Turley, H., Campo, L., Han, C., Gatter, K.C., Bhattacharya, S., Harris, A.L. Cancer Res. (2004) [Pubmed]
  2. Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q. Tews, B., Roerig, P., Hartmann, C., Hahn, M., Felsberg, J., Blaschke, B., Sabel, M., Kunitz, A., Toedt, G., Neben, K., Benner, A., von Deimling, A., Reifenberger, G., Lichter, P. Oncogene (2007) [Pubmed]
  3. Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. Bragança, J., Swingler, T., Marques, F.I., Jones, T., Eloranta, J.J., Hurst, H.C., Shioda, T., Bhattacharya, S. J. Biol. Chem. (2002) [Pubmed]
 
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