Gene Review:
AKR1C1 - aldo-keto reductase family 1, member C1
Homo sapiens
Synonyms:
2-ALPHA-HSD, 20-ALPHA-HSD, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, Aldo-keto reductase family 1 member C1, ...
- Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling. Ji, Q., Aoyama, C., Nien, Y.D., Liu, P.I., Chen, P.K., Chang, L., Stanczyk, F.Z., Stolz, A. Cancer Res. (2004)
- Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Burczynski, M.E., Lin, H.K., Penning, T.M. Cancer Res. (1999)
- AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer. Rizner, T.L., Smuc, T., Rupreht, R., Sinkovec, J., Penning, T.M. Mol. Cell. Endocrinol. (2006)
- Inverse expression of dihydrodiol dehydrogenase and glutathione-S-transferase in patients with esophageal squamous cell carcinoma. Wang, L.S., Chow, K.C., Wu, Y.C., Lin, T.Y., Li, W.Y. Int. J. Cancer (2004)
- Up-regulated production and activation of the complement system in Alzheimer's disease brain. Yasojima, K., Schwab, C., McGeer, E.G., McGeer, P.L. Am. J. Pathol. (1999)
- Induction of complement C9 messenger RNAs in human neuronal cells by inflammatory stimuli: relevance to neurodegenerative disorders. Klegeris, A., Schwab, C., Bissonnette, C.J., McGeer, P.L. Exp. Gerontol. (2001)
- The human complement system in thrombin-mediated platelet function. Polley, M.J., Nachman, R. J. Exp. Med. (1978)
- Arachidonic acid metabolites in hepatobiliary physiology and disease. Kaminski, D.L. Gastroenterology (1989)
- Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Karakas, E., Truglio, J.J., Croteau, D., Rhau, B., Wang, L., Van Houten, B., Kisker, C. EMBO J. (2007)
- How human neuroblastoma cells make morphine. Boettcher, C., Fellermeier, M., Boettcher, C., Dräger, B., Zenk, M.H. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The C9 methyl group of retinal interacts with glycine-121 in rhodopsin. Han, M., Groesbeek, M., Sakmar, T.P., Smith, S.O. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Gene expression profiles of HeLa Cells impacted by hepatitis C virus non-structural protein NS4B. Zheng, Y., Ye, L.B., Liu, J., Jing, W., Timani, K.A., Yang, X.J., Yang, F., Wang, W., Gao, B., Wu, Z.H. J. Biochem. Mol. Biol. (2005)
- Ubiquitous induction of resistance to platinum drugs in human ovarian, cervical, germ-cell and lung carcinoma tumor cells overexpressing isoforms 1 and 2 of dihydrodiol dehydrogenase. Deng, H.B., Adikari, M., Parekh, H.K., Simpkins, H. Cancer Chemother. Pharmacol. (2004)
- C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. Cudrici, C., Niculescu, F., Jensen, T., Zafranskaia, E., Fosbrink, M., Rus, V., Shin, M.L., Rus, H. J. Immunol. (2006)
- Molecular characterization of two monkey dihydrodiol dehydrogenases. Higaki, Y., Kamiya, T., Usami, N., Shintani, S., Shiraishi, H., Ishikura, S., Yamamoto, I., Hara, A. Drug Metab. Pharmacokinet. (2002)
- The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. Burczynski, M.E., Sridhar, G.R., Palackal, N.T., Penning, T.M. J. Biol. Chem. (2001)
- Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder. Deyashiki, Y., Ogasawara, A., Nakayama, T., Nakanishi, M., Miyabe, Y., Sato, K., Hara, A. Biochem. J. (1994)
- Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. O'connor, T., Ireland, L.S., Harrison, D.J., Hayes, J.D. Biochem. J. (1999)
- Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men. Blouin, K., Richard, C., Brochu, G., Hould, F.S., Lebel, S., Marceau, S., Biron, S., Luu-The, V., Tchernof, A. J. Endocrinol. (2006)
- Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily. Steckelbroeck, S., Oyesanmi, B., Jin, Y., Lee, S.H., Kloosterboer, H.J., Penning, T.M. J. Pharmacol. Exp. Ther. (2006)
- Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol. Atalla, A., Breyer-Pfaff, U., Maser, E. Xenobiotica (2000)
- Induction of AKR1C2 by phase II inducers: identification of a distal consensus antioxidant response element regulated by NRF2. Lou, H., Du, S., Ji, Q., Stolz, A. Mol. Pharmacol. (2006)
- Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms. Penning, T.M., Jin, Y., Heredia, V.V., Lewis, M. J. Steroid Biochem. Mol. Biol. (2003)
- Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Bonnesen, C., Eggleston, I.M., Hayes, J.D. Cancer Res. (2001)
- Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding. Lou, H., Hammond, L., Sharma, V., Sparkes, R.S., Lusis, A.J., Stolz, A. J. Biol. Chem. (1994)
- High-affinity stereoselective reduction of the enantiomers of ketotifen and of ketonic nortriptyline metabolites by aldo-keto reductases from human liver. Breyer-Pfaff, U., Nill, K. Biochem. Pharmacol. (2000)
- Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesis. Matsuura, K., Deyashiki, Y., Sato, K., Ishida, N., Miwa, G., Hara, A. Biochem. J. (1997)