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Gene Review: 

Junb  -  Jun-B oncogene

Mus musculus

Synonyms: Jun-b, MyD21, Transcription factor jun-B
 
 
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Disease relevance of Junb

 

High impact information on Junb

  • The AP-1 transcription factor JunB is a transcriptional regulator of myelopoiesis [2].
  • Here we show, by a knock-in strategy and a transgenic complementation approach, that Junb can substitute for absence of Jun during mouse development [3].
  • A role for the transcription factor JunB in proliferation control was investigated in genetically modified mouse fibroblasts [4].
  • Linkage and genetic distance were established for 10 loci by analysis of 114 meiotic events and indicated the following gene order: (centromere)-Insr-3.5 cM-Plat-26.3 cM-Crryps/Mel/Jund-3.5 cM-Junb/Ucp-10.5 cM-Mt-1-27.2 cM-Acta2-0.9 cM-Aprt [5].
  • Probes for jun D identified two genetic loci; one, Jund-1, is near Junb on Chr 8, and a second, previously unidentified locus termed Jund-2, was mapped to Chr 2 [6].
 

Biological context of Junb

  • Junb can rescue both liver and cardiac defects in Jun-null mice in a manner dependent on gene dosage [3].
  • The murine homolog of v-jun, Jun, was mapped to chromosome (Chr) 4, and a locus containing jun B-related sequences (Junb) was mapped to Chr 8 [6].

References

  1. PU.1 and Junb: Suppressing the formation of acute myeloid leukemia stem cells. Somervaille, T.C., Cleary, M.L. Cancer Cell (2006) [Pubmed]
  2. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Passegué, E., Wagner, E.F., Weissman, I.L. Cell (2004) [Pubmed]
  3. JunB can substitute for Jun in mouse development and cell proliferation. Passegué, E., Jochum, W., Behrens, A., Ricci, R., Wagner, E.F. Nat. Genet. (2002) [Pubmed]
  4. JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression. Passegué, E., Wagner, E.F. EMBO J. (2000) [Pubmed]
  5. A linkage map of mouse chromosome 8: further definition of homologous linkage relationships between mouse chromosome 8 and human chromosomes 8, 16, and 19. Howard, T.A., Rochelle, J.M., Saunders, A.M., Seldin, M.F. Genomics (1991) [Pubmed]
  6. Genetic mapping in the mouse of four loci related to the jun family of transcriptional activators. Shapiro, M., Kozak, C.A. Somat. Cell Mol. Genet. (1991) [Pubmed]
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