Gene Review:
Klf1 - Kruppel-like factor 1 (erythroid)
Mus musculus
Synonyms:
EKLF, Eklf, Elkf, Erythroid krueppel-like transcription factor, Krueppel-like factor 1, ...
- Retroviral integration within the Fli-2 locus results in inactivation of the erythroid transcription factor NF-E2 in Friend erythroleukemias: evidence that NF-E2 is essential for globin expression. Lu, S.J., Rowan, S., Bani, M.R., Ben-David, Y. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos. Perkins, A.C., Peterson, K.R., Stamatoyannopoulos, G., Witkowska, H.E., Orkin, S.H. Blood (2000)
- Transactivation of erythroid transcription factor GATA-1 by a myb-ets-containing retrovirus. Aurigemma, R.E., Blair, D.G., Ruscetti, S.K. J. Virol. (1992)
- Regulation of activity of the transcription factor GATA-1 by acetylation. Boyes, J., Byfield, P., Nakatani, Y., Ogryzko, V. Nature (1998)
- Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Perkins, A.C., Sharpe, A.H., Orkin, S.H. Nature (1995)
- Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis. Ito, E., Toki, T., Ishihara, H., Ohtani, H., Gu, L., Yokoyama, M., Engel, J.D., Yamamoto, M. Nature (1993)
- Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. Kabashima, K., Haynes, N.M., Xu, Y., Nutt, S.L., Allende, M.L., Proia, R.L., Cyster, J.G. J. Exp. Med. (2006)
- Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region. Tewari, R., Gillemans, N., Wijgerde, M., Nuez, B., von Lindern, M., Grosveld, F., Philipsen, S. EMBO J. (1998)
- Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. Crossley, M., Tsang, A.P., Bieker, J.J., Orkin, S.H. J. Biol. Chem. (1994)
- Loss of LKLF function results in embryonic lethality in mice. Wani, M.A., Means, R.T., Lingrel, J.B. Transgenic Res. (1998)
- Multiple proteins binding to a GATA-E box-GATA motif regulate the erythroid Krüppel-like factor (EKLF) gene. Anderson, K.P., Crable, S.C., Lingrel, J.B. J. Biol. Chem. (1998)
- Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Matsumoto, N., Kubo, A., Liu, H., Akita, K., Laub, F., Ramirez, F., Keller, G., Friedman, S.L. Blood (2006)
- A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains. Lim, S.K., Bieker, J.J., Lin, C.S., Costantini, F. Blood (1997)
- Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice. Coghill, E., Eccleston, S., Fox, V., Cerruti, L., Brown, C., Cunningham, J., Jane, S., Perkins, A. Blood (2001)
- The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Drissen, R., von Lindern, M., Kolbus, A., Driegen, S., Steinlein, P., Beug, H., Grosveld, F., Philipsen, S. Mol. Cell. Biol. (2005)
- A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Miller, I.J., Bieker, J.J. Mol. Cell. Biol. (1993)
- Regulation of the erythroid transcription factor NF-E2 by cyclic adenosine monophosphate-dependent protein kinase. Casteel, D., Suhasini, M., Gudi, T., Naima, R., Pilz, R.B. Blood (1998)
- Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1. Blobel, G.A., Orkin, S.H. Mol. Cell. Biol. (1996)
- Modification of the erythroid transcription factor GATA-1 by SUMO-1. Collavin, L., Gostissa, M., Avolio, F., Secco, P., Ronchi, A., Santoro, C., Del Sal, G. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. Gray, S., Feinberg, M.W., Hull, S., Kuo, C.T., Watanabe, M., Sen-Banerjee, S., DePina, A., Haspel, R., Jain, M.K. J. Biol. Chem. (2002)
- Chromatin-binding in vivo of the erythroid kruppel-like factor, EKLF, in the murine globin loci. Shyu, Y.C., Wen, S.C., Lee, T.L., Chen, X., Hsu, C.T., Chen, H., Chen, R.L., Hwang, J.L., Shen, C.K. Cell Res. (2006)
- Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Merika, M., Orkin, S.H. Mol. Cell. Biol. (1995)
- beta-Minor globin gene expression is preferentially reduced in EKLF Knock-Out mice. Porcu, S., Poddie, D., Melis, M., Cao, A., Ristaldi, M.S. Gene (2005)
- The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media. Adelman, C.A., Chattopadhyay, S., Bieker, J.J. Development (2002)
- Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Southwood, C.M., Downs, K.M., Bieker, J.J. Dev. Dyn. (1996)