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Klf9  -  Kruppel-like factor 9

Mus musculus

Synonyms: 2310051E17Rik, AA589643, BTE-binding protein 1, BTEB-1, Basic transcription element-binding protein 1, ...
 
 
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High impact information on Klf9

 

Biological context of Klf9

  • Here we report that ablation of the Bteb1 gene in female mice results in uterine hypoplasia, reduced litter size, and increased incidence of neonatal deaths in offspring [2].
  • Klf9 and Klf13 are members of the C(2)H(2) zinc finger family of transcription factors that are thought to be involved in regulating basal transcription [3].
  • AP-2rep, BTEB-1, and AP-2 interact in a mutually exclusive manner with overlapping binding sites in the A32 element [4].
  • To address this, endometrium from wild-type (WT) and Bteb1(-/-) females at 0.5 to 5.5 days postcoitum (dpc) were evaluated for proliferation (BrdU labeling), apoptosis (TUNEL), and steroid hormone receptor expression (immunohistochemistry) [5].
  • The numbers of PGR-positive ST cells was negatively correlated with LE proliferation in WT mice; this correlation was lost in Bteb1(-/-) mice and was not observed before 2.5 dpc for both genotypes [5].
 

Anatomical context of Klf9

  • In the early pregnant uterus, Bteb1 expression in stromal cells temporally coincides with PR-A isoform-dependent decidual formation at the time of implantation [2].
  • In the gut and bladder at E16, Klf13 is expressed in the epithelial cell layer whereas Klf9 is expressed in both the muscle and epithelial layers [3].
  • At E11, both genes are expressed in high levels in the cephalic mesenchyme whilst Klf13 and not Klf9 is expressed at high levels in the developing heart at E8 and E11 [3].
  • Although general behavioral activities such as locomotion, rearing, and speed of movement were not so much affected in the BTEB(-/-) mutant mice, they showed clearly reduced activity levels in rotorod and contextual fear-conditioning tests; this finding was probably due to defective functions of the cerebellum, hippocampus, and amygdala [1].
  • Results suggest that BTEB1, by regulating ST PGR expression and transactivation, participates in the paracrine control of LE proliferation by PGR and thus is important for establishment of a receptive uterus critical for successful implantation [5].
 

Associations of Klf9 with chemical compounds

 

Other interactions of Klf9

  • Proliferation and apoptosis in all endometrial compartments, as well as the numbers of PGR-, HOXA10-, and ESR1-expressing ST cells, were lower in Bteb1(-/-) relative to WT mice after ovariectomy and E + P treatment [5].
 

Analytical, diagnostic and therapeutic context of Klf9

References

  1. Functional analysis of basic transcription element binding protein by gene targeting technology. Morita, M., Kobayashi, A., Yamashita, T., Shimanuki, T., Nakajima, O., Takahashi, S., Ikegami, S., Inokuchi, K., Yamashita, K., Yamamoto, M., Fujii-Kuriyama, Y. Mol. Cell. Biol. (2003) [Pubmed]
  2. Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene. Simmen, R.C., Eason, R.R., McQuown, J.R., Linz, A.L., Kang, T.J., Chatman, L., Till, S.R., Fujii-Kuriyama, Y., Simmen, F.A., Oh, S.P. J. Biol. Chem. (2004) [Pubmed]
  3. Expression of Klf9 and Klf13 in mouse development. Martin, K.M., Metcalfe, J.C., Kemp, P.R. Mech. Dev. (2001) [Pubmed]
  4. Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. Imhof, A., Schuierer, M., Werner, O., Moser, M., Roth, C., Bauer, R., Buettner, R. Mol. Cell. Biol. (1999) [Pubmed]
  5. Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice. Velarde, M.C., Geng, Y., Eason, R.R., Simmen, F.A., Simmen, R.C. Biol. Reprod. (2005) [Pubmed]
 
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