Gene Review:
Kras - v-Ki-ras2 Kirsten rat sarcoma viral...
Mus musculus
Synonyms:
AI929937, GTPase KRas, K-Ras 2, K-ras, Ki-Ras, ...
- Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Aguirre, A.J., Bardeesy, N., Sinha, M., Lopez, L., Tuveson, D.A., Horner, J., Redston, M.S., DePinho, R.A. Genes Dev. (2003)
- Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Braun, B.S., Tuveson, D.A., Kong, N., Le, D.T., Kogan, S.C., Rozmus, J., Le Beau, M.M., Jacks, T.E., Shannon, K.M. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice. Grippo, P.J., Nowlin, P.S., Demeure, M.J., Longnecker, D.S., Sandgren, E.P. Cancer Res. (2003)
- Comparison of gene expression and DNA copy number changes in a murine model of lung cancer. Sweet-Cordero, A., Tseng, G.C., You, H., Douglass, M., Huey, B., Albertson, D., Jacks, T. Genes Chromosomes Cancer (2006)
- The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors. Compere, S.J., Baldacci, P., Sharpe, A.H., Thompson, T., Land, H., Jaenisch, R. Proc. Natl. Acad. Sci. U.S.A. (1989)
- An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis. Sweet-Cordero, A., Mukherjee, S., Subramanian, A., You, H., Roix, J.J., Ladd-Acosta, C., Mesirov, J., Golub, T.R., Jacks, T. Nat. Genet. (2005)
- Stem cells for lung cancer? Berns, A. Cell (2005)
- Nf1 has an essential role in endothelial cells. Gitler, A.D., Zhu, Y., Ismat, F.A., Lu, M.M., Yamauchi, Y., Parada, L.F., Epstein, J.A. Nat. Genet. (2003)
- Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Kapfhamer, D., Valladares, O., Sun, Y., Nolan, P.M., Rux, J.J., Arnold, S.E., Veasey, S.C., Bućan, M. Nat. Genet. (2002)
- Genetic alterations of p53 and ras genes in 1,3-butadiene- and 2',3'-dideoxycytidine-induced lymphomas. Zhuang, S.M., Cochran, C., Goodrow, T., Wiseman, R.W., Söderkvist, P. Cancer Res. (1997)
- Mutagenesis of ras proto-oncogenes in rat liver tumors induced by vinyl chloride. Froment, O., Boivin, S., Barbin, A., Bancel, B., Trepo, C., Marion, M.J. Cancer Res. (1994)
- Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Taylor, M.T., Lawson, K.R., Ignatenko, N.A., Marek, S.E., Stringer, D.E., Skovan, B.A., Gerner, E.W. Cancer Res. (2000)
- Protooncogene expression in normal, preleukemic, and leukemic murine erythroid cells and its relationship to differentiation and proliferation. Robert-Lézénès, J., Meneceur, P., Ray, D., Moreau-Gachelin, F. Cancer Res. (1988)
- Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis. Uhrbom, L., Kastemar, M., Johansson, F.K., Westermark, B., Holland, E.C. Cancer Res. (2005)
- Frequent retention of heterozygosity for point mutations in p53 and Ikaros in N-ethyl-N-nitrosourea-induced mouse thymic lymphomas. Kakinuma, S., Nishimura, M., Kubo, A., Nagai, J.Y., Amasaki, Y., Majima, H.J., Sado, T., Shimada, Y. Mutat. Res. (2005)
- Chromosomal instability in mouse metastatic pancreatic cancer--it's Kras and Tp53 after all. Siveke, J.T., Schmid, R.M. Cancer Cell (2005)
- Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C. Seuwen, K., Lagarde, A., Pouysségur, J. EMBO J. (1988)
- Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma. Vousden, K.H., Marshall, C.J. EMBO J. (1984)
- Activation of ras oncogene in aflatoxin-induced rat liver carcinogenesis. Sinha, S., Webber, C., Marshall, C.J., Knowles, M.A., Proctor, A., Barrass, N.C., Neal, G.E. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Jackson, J.H., Cochrane, C.G., Bourne, J.R., Solski, P.A., Buss, J.E., Der, C.J. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. Albright, C.F., Giddings, B.W., Liu, J., Vito, M., Weinberg, R.A. EMBO J. (1993)
- Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes. Yoshida, Y., Kawata, M., Miura, Y., Musha, T., Sasaki, T., Kikuchi, A., Takai, Y. Mol. Cell. Biol. (1992)
- An affinity labeling of ras p21 protein and its use in the identification of ras p21 in cellular and tissue extracts. Basu, A., Modak, M.J. J. Biol. Chem. (1987)
- Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. Qian, Y.W., Lee, E.Y. J. Biol. Chem. (1995)
- Mechanism of carcinogenesis: the role of oncogenes, transcriptional enhancers and growth factors. Spandidos, D.A. Anticancer Res. (1985)
- Codon 12 region of mouse K-ras gene is the site for in vitro binding of transcription factors GATA-6 and NF-Y. Gorshkova, E.V., Kaledin, V.I., Kobzev, V.F., Merkulova, T.I. Biochemistry Mosc. (2005)
- K-ras regulates the steady-state expression of matrix metalloproteinase 2 in fibroblasts. Liao, J., Wolfman, J.C., Wolfman, A. J. Biol. Chem. (2003)
- Radiation and chemical activation of ras oncogenes in different mouse strains. Newcomb, E.W., Diamond, L.E., Sloan, S.R., Corominas, M., Guerrerro, I., Pellicer, A. Environ. Health Perspect. (1989)
- Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Tuveson, D.A., Zhu, L., Gopinathan, A., Willis, N.A., Kachatrian, L., Grochow, R., Pin, C.L., Mitin, N.Y., Taparowsky, E.J., Gimotty, P.A., Hruban, R.H., Jacks, T., Konieczny, S.F. Cancer Res. (2006)
- Transforming and c-fos promoter/enhancer-stimulating activities of a stimulatory GDP/GTP exchange protein for small GTP-binding proteins. Fujioka, H., Kaibuchi, K., Kishi, K., Yamamoto, T., Kawamura, M., Sakoda, T., Mizuno, T., Takai, Y. J. Biol. Chem. (1992)
- Radiosensitizing Effects of the Prenyltransferase Inhibitor AZD3409 against RAS Mutated Cell Lines. Cengel, K.A., Deutsch, E., Stephens, T.C., Voong, K.R., Kao, G.D., Bernhard, E.J. Cancer Biol. Ther. (2006)
- A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Guerrero, I., Calzada, P., Mayer, A., Pellicer, A. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression. Takahashi, C., Contreras, B., Bronson, R.T., Loda, M., Ewen, M.E. Mol. Cell. Biol. (2004)
- Correlation of genetic instability and apoptosis in the presence of oncogenic Ki-Ras. Chen, C.Y., Liou, J., Forman, L.W., Faller, D.V. Cell Death Differ. (1998)
- Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties. Bearss, D.J., Lee, R.J., Troyer, D.A., Pestell, R.G., Windle, J.J. Cancer Res. (2002)
- Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Johnson, L., Mercer, K., Greenbaum, D., Bronson, R.T., Crowley, D., Tuveson, D.A., Jacks, T. Nature (2001)
- Identification of an activated c-Ki-ras oncogene in rat liver tumors induced by aflatoxin B1. McMahon, G., Hanson, L., Lee, J.J., Wogan, G.N. Proc. Natl. Acad. Sci. U.S.A. (1986)