Gene Review:
DEFA5 - defensin, alpha 5, Paneth cell-specific
Homo sapiens
Synonyms:
DEF5, Defensin, alpha 5, Defensin-5, HD-5, HD5(20-94)
- High level expression of human epithelial beta-defensins (hBD-1, 2 and 3) in papillomavirus induced lesions. Chong, K.T., Xiang, L., Wang, X., Jun, E.L., Xi, L.F., Schweinfurth, J.M. Virol. J. (2006)
- Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Salzman, N.H., Ghosh, D., Huttner, K.M., Paterson, Y., Bevins, C.L. Nature (2003)
- Antibacterial activity and specificity of the six human {alpha}-defensins. Ericksen, B., Wu, Z., Lu, W., Lehrer, R.I. Antimicrob. Agents Chemother. (2005)
- Enteric defensin expression in necrotizing enterocolitis. Salzman, N.H., Polin, R.A., Harris, M.C., Ruchelli, E., Hebra, A., Zirin-Butler, S., Jawad, A., Martin Porter, E., Bevins, C.L. Pediatr. Res. (1998)
- Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis. Fahlgren, A., Hammarström, S., Danielsson, A., Hammarström, M.L. Clin. Exp. Immunol. (2003)
- Paneth cell trypsin is the processing enzyme for human defensin-5. Ghosh, D., Porter, E., Shen, B., Lee, S.K., Wilk, D., Drazba, J., Yadav, S.P., Crabb, J.W., Ganz, T., Bevins, C.L. Nat. Immunol. (2002)
- Human enteric defensins. Gene structure and developmental expression. Mallow, E.B., Harris, A., Salzman, N., Russell, J.P., DeBerardinis, R.J., Ruchelli, E., Bevins, C.L. J. Biol. Chem. (1996)
- Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships. Bevins, C.L., Jones, D.E., Dutra, A., Schaffzin, J., Muenke, M. Genomics (1996)
- Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Quayle, A.J., Porter, E.M., Nussbaum, A.A., Wang, Y.M., Brabec, C., Yip, K.P., Mok, S.C. Am. J. Pathol. (1998)
- NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Wehkamp, J., Harder, J., Weichenthal, M., Schwab, M., Schäffeler, E., Schlee, M., Herrlinger, K.R., Stallmach, A., Noack, F., Fritz, P., Schröder, J.M., Bevins, C.L., Fellermann, K., Stange, E.F. Gut (2004)
- Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Wehkamp, J., Salzman, N.H., Porter, E., Nuding, S., Weichenthal, M., Petras, R.E., Shen, B., Schaeffeler, E., Schwab, M., Linzmeier, R., Feathers, R.W., Chu, H., Lima, H., Fellermann, K., Ganz, T., Stange, E.F., Bevins, C.L. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Structure-dependent functional properties of human defensin 5. de Leeuw, E., Burks, S.R., Li, X., Kao, J.P., Lu, W. FEBS Lett. (2007)
- Comparative study of the lubricant performance of Compritol HD5 ATO and Compritol 888 ATO: effect of polyethylene glycol behenate on lubricant capacity. N'Diaye, A., Jannin, V., Bérard, V., Andrès, C., Pourcelot, Y. International journal of pharmaceutics. (2003)
- Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Lawrance, I.C., Fiocchi, C., Chakravarti, S. Hum. Mol. Genet. (2001)
- Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status. Wehkamp, J., Schmidt, K., Herrlinger, K.R., Baxmann, S., Behling, S., Wohlschläger, C., Feller, A.C., Stange, E.F., Fellermann, K. J. Clin. Pathol. (2003)
- Localization of human intestinal defensin 5 in Paneth cell granules. Porter, E.M., Liu, L., Oren, A., Anton, P.A., Ganz, T. Infect. Immun. (1997)
- Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. Zhao, C., Wang, I., Lehrer, R.I. FEBS Lett. (1996)
- Effect of surface electrode positioning on the compound action potential evoked by ulnar nerve stimulation in anaesthetized infants and children. Kalli, I. British journal of anaesthesia. (1989)