Gene Review:
DEFB4A - defensin, beta 4A
Homo sapiens
Synonyms:
BD-2, DEFB-2, DEFB102, DEFB2, DEFB4, ...
Armour,
Barber,
Schaeffeler,
Wehkamp,
Schröder,
Lee,
Sonnenborn,
Wehkamp,
Andalibi,
Radlwimmer,
Pan,
Wehkamp-von Meissner,
Gudmundsson,
Teml,
Schwab,
Enders,
Starner,
Schlee,
Agerberth,
Park,
Schmalzl,
Chung,
Hollox,
Marta Ramirez Gaite,
Moon,
Fellermann,
Linzmeier,
Bengmark,
McCray,
Lim,
Wehkamp,
Lichter,
Dale,
Fellermann,
Cheng-Yuan Kao,
Stange,
Harder,
Reinisch,
Cha,
Ganz,
Takeshita,
Nuding,
Stange,
Stange,
Bevins,
- Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. Hollox, E.J., Armour, J.A., Barber, J.C. Am. J. Hum. Genet. (2003)
- Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1. Wehkamp, K., Schwichtenberg, L., Schröder, J.M., Harder, J. J. Invest. Dermatol. (2006)
- Innate immune response of oral and foreskin keratinocytes: utilization of different signaling pathways by various bacterial species. Chung, W.O., Dale, B.A. Infect. Immun. (2004)
- Human beta-defensin-3 induction in H pylori-infected gastric mucosal tissues. Kawauchi, K., Yagihashi, A., Tsuji, N., Uehara, N., Furuya, D., Kobayashi, D., Watanabe, N. World J. Gastroenterol. (2006)
- Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells. Kumar, A., Zhang, J., Yu, F.S. Microbes Infect. (2006)
- Production of endogenous antibiotics in articular cartilage. Varoga, D., Pufe, T., Harder, J., Meyer-Hoffert, U., Mentlein, R., Schröder, J.M., Petersen, W.J., Tillmann, B.N., Proksch, E., Goldring, M.B., Paulsen, F.P. Arthritis Rheum. (2004)
- Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. Bals, R., Wang, X., Wu, Z., Freeman, T., Bafna, V., Zasloff, M., Wilson, J.M. J. Clin. Invest. (1998)
- The ets gene family. Macleod, K., Leprince, D., Stehelin, D. Trends Biochem. Sci. (1992)
- Identification of a heparin binding domain of the neural cell adhesion molecule N-CAM using synthetic peptides. Cole, G.J., Akeson, R. Neuron (1989)
- A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Fellermann, K., Stange, D.E., Schaeffeler, E., Schmalzl, H., Wehkamp, J., Bevins, C.L., Reinisch, W., Teml, A., Schwab, M., Lichter, P., Radlwimmer, B., Stange, E.F. Am. J. Hum. Genet. (2006)
- NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. Voss, E., Wehkamp, J., Wehkamp, K., Stange, E.F., Schröder, J.M., Harder, J. J. Biol. Chem. (2006)
- Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. Niyonsaba, F., Someya, A., Hirata, M., Ogawa, H., Nagaoka, I. Eur. J. Immunol. (2001)
- NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Wehkamp, J., Harder, J., Wehkamp, K., Wehkamp-von Meissner, B., Schlee, M., Enders, C., Sonnenborn, U., Nuding, S., Bengmark, S., Fellermann, K., Schröder, J.M., Stange, E.F. Infect. Immun. (2004)
- Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway. Niyonsaba, F., Iwabuchi, K., Matsuda, H., Ogawa, H., Nagaoka, I. Int. Immunol. (2002)
- Structure of the lysosomal sphingolipid activator protein 1 by homology with influenza virus neuraminidase. Potier, M. Biochem. Biophys. Res. Commun. (1988)
- Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populations. Vankeerberghen, A., Scudiero, O., De Boeck, K., Macek, M., Pignatti, P.F., Van Hul, N., Nuytten, H., Salvatore, F., Castaldo, G., Zemkova, D., Vavrova, V., Cassiman, J.J., Cuppens, H. Genomics (2005)
- Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Linzmeier, R.M., Ganz, T. Genomics (2005)
- Expression and activity of beta-defensins and LL-37 in the developing human lung. Starner, T.D., Agerberth, B., Gudmundsson, G.H., McCray, P.B. J. Immunol. (2005)
- IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. Kao, C.Y., Chen, Y., Thai, P., Wachi, S., Huang, F., Kim, C., Harper, R.W., Wu, R. J. Immunol. (2004)
- Antimicrobial peptides are present in immune and host defense cells of the human respiratory and gastroinstestinal tracts. Wah, J., Wellek, A., Frankenberger, M., Unterberger, P., Welsch, U., Bals, R. Cell Tissue Res. (2006)
- Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree. Harada, K., Ohba, K., Ozaki, S., Isse, K., Hirayama, T., Wada, A., Nakanuma, Y. Hepatology (2004)
- Human {alpha}- and beta-Defensins Block Multiple Steps in Herpes Simplex Virus Infection. Hazrati, E., Galen, B., Lu, W., Wang, W., Ouyang, Y., Keller, M.J., Lehrer, R.I., Herold, B.C. J. Immunol. (2006)
- Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells. Ouhara, K., Komatsuzawa, H., Shiba, H., Uchida, Y., Kawai, T., Sayama, K., Hashimoto, K., Taubman, M.A., Kurihara, H., Sugai, M. Infect. Immun. (2006)
- Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS. Chadebech, P., Goidin, D., Jacquet, C., Viac, J., Schmitt, D., Staquet, M.J. Cell Biol. Toxicol. (2003)
- Transcriptional regulation of beta-defensin-2 by lipopolysaccharide in cultured human cervical carcinoma (HeLa) cells. Mineshiba, J., Myokai, F., Mineshiba, F., Matsuura, K., Nishimura, F., Takashiba, S. FEMS Immunol. Med. Microbiol. (2005)
- NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation. Tsutsumi-Ishii, Y., Nagaoka, I. J. Leukoc. Biol. (2002)
- Correlation between beta-defensin expression and induction profiles in gingival keratinocytes. Joly, S., Organ, C.C., Johnson, G.K., McCray, P.B., Guthmiller, J.M. Mol. Immunol. (2005)
- Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells. Moon, S.K., Lee, H.Y., Pan, H., Takeshita, T., Park, R., Cha, K., Andalibi, A., Lim, D.J. BMC Infect. Dis. (2006)
- The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. Schibli, D.J., Hunter, H.N., Aseyev, V., Starner, T.D., Wiencek, J.M., McCray, P.B., Tack, B.F., Vogel, H.J. J. Biol. Chem. (2002)
- Airway epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2. Wang, X., Zhang, Z., Louboutin, J.P., Moser, C., Weiner, D.J., Wilson, J.M. FASEB J. (2003)