Gene Review:
Lgals3 - lectin, galactose binding, soluble 3
Mus musculus
Synonyms:
35 kDa lectin, CBP 35, Carbohydrate-binding protein 35, GBP, Gal-3, ...
- Galectins-1 and -3 and their ligands in tumor biology. Non-uniform properties in cell-surface presentation and modulation of adhesion to matrix glycoproteins for various tumor cell lines, in biodistribution of free and liposome-bound galectins and in their expression by breast and colorectal carcinomas with/without metastatic propensity. André, S., Kojima, S., Yamazaki, N., Fink, C., Kaltner, H., Kayser, K., Gabius, H.J. J. Cancer Res. Clin. Oncol. (1999)
- Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Henderson, N.C., Mackinnon, A.C., Farnworth, S.L., Poirier, F., Russo, F.P., Iredale, J.P., Haslett, C., Simpson, K.J., Sethi, T. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate. Ohannesian, D.W., Lotan, D., Lotan, R. Cancer Res. (1994)
- Biochemical and immunological characterization of K-1735P melanoma galactoside-binding lectins and their modulation by differentiation inducers. Lotan, R., Carralero, D., Lotan, D., Raz, A. Cancer Res. (1989)
- Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function. Farnworth, S.L., Henderson, N.C., Mackinnon, A.C., Atkinson, K.M., Wilkinson, T., Dhaliwal, K., Hayashi, K., Simpson, A.J., Rossi, A.G., Haslett, C., Sethi, T. Am. J. Pathol. (2008)
- Galectin-3 gene inactivation reduces atherosclerotic lesions and adventitial inflammation in ApoE-deficient mice. Nachtigal, M., Ghaffar, A., Mayer, E.P. Am. J. Pathol. (2008)
- Localization of a laminin-binding protein in brain. Jucker, M., Walker, L.C., Kibbey, M.C., Kleinman, H.K., Ingram, D.K. Neuroscience (1993)
- Galectin-3 decreases in mice exposed to immobilization stress. Dumić, J., Barisić, K., Flögel, M., Lauc, G. Stress (Amsterdam, Netherlands) (2000)
- Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene. Dombrowicz, D., Flamand, V., Brigman, K.K., Koller, B.H., Kinet, J.P. Cell (1993)
- Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII. Takizawa, F., Adamczewski, M., Kinet, J.P. J. Exp. Med. (1992)
- The Mac-2 antigen is a galactose-specific lectin that binds IgE. Cherayil, B.J., Weiner, S.J., Pillai, S. J. Exp. Med. (1989)
- Expression of two different endogenous galactoside-binding lectins sharing sequence homology. Raz, A., Carmi, P., Pazerini, G. Cancer Res. (1988)
- Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia. Sato, S., Ouellet, N., Pelletier, I., Simard, M., Rancourt, A., Bergeron, M.G. J. Immunol. (2002)
- Galectin-3 promotes neural cell adhesion and neurite growth. Pesheva, P., Kuklinski, S., Schmitz, B., Probstmeier, R. J. Neurosci. Res. (1998)
- A parallel association between differentiation and induction of galectin-1, and inhibition of galectin-3 by retinoic acid in mouse embryonal carcinoma F9 cells. Lu, Y., Amos, B., Cruise, E., Lotan, D., Lotan, R. Biol. Chem. (1998)
- Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. Nangia-Makker, P., Hogan, V., Honjo, Y., Baccarini, S., Tait, L., Bresalier, R., Raz, A. J. Natl. Cancer Inst. (2002)
- Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds. Cao, Z., Said, N., Amin, S., Wu, H.K., Bruce, A., Garate, M., Hsu, D.K., Kuwabara, I., Liu, F.T., Panjwani, N. J. Biol. Chem. (2002)
- Differential expression of two beta-galactoside-binding lectins in the reproductive tracts of pregnant mice. Phillips, B., Knisley, K., Weitlauf, K.D., Dorsett, J., Lee, V., Weitlauf, H. Biol. Reprod. (1996)
- Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling. Liu, L., Sakai, T., Sano, N., Fukui, K. Biochem. J. (2004)
- Galectin-3 expression in macrophages is signaled by Ras/MAP kinase pathway and up-regulated by modified lipoproteins. Kim, K., Mayer, E.P., Nachtigal, M. Biochim. Biophys. Acta (2003)
- Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity. Elad-Sfadia, G., Haklai, R., Balan, E., Kloog, Y. J. Biol. Chem. (2004)
- Cubilin, a binding partner for galectin-3 in the murine utero-placental complex. Crider-Pirkle, S., Billingsley, P., Faust, C., Hardy, D.M., Lee, V., Weitlauf, H. J. Biol. Chem. (2002)
- Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen. Oda, Y., Leffler, H., Sakakura, Y., Kasai, K., Barondes, S.H. Gene (1991)
- NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Fukushi, J., Makagiansar, I.T., Stallcup, W.B. Mol. Biol. Cell (2004)
- Carbohydrate-binding protein 35 (Mac-2), a laminin-binding lectin, forms functional dimers using cysteine 186. Woo, H.J., Lotz, M.M., Jung, J.U., Mercurio, A.M. J. Biol. Chem. (1991)
- UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,6 N-acetylglucosaminyltransferase V (Mgat5) deficient mice. Dennis, J.W., Pawling, J., Cheung, P., Partridge, E., Demetriou, M. Biochim. Biophys. Acta (2002)
- Specificity of interactions of galectin-3 with Chrp, a cysteine- and histidine-rich cytoplasmic protein. Bawumia, S., Barboni, E.A., Menon, R.P., Hughes, R.C. Biochimie (2003)
- Midkine binds to 37-kDa laminin binding protein precursor, leading to nuclear transport of the complex. Salama, R.H., Muramatsu, H., Zou, K., Inui, T., Kimura, T., Muramatsu, T. Exp. Cell Res. (2001)
- Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells. Lagana, A., Goetz, J.G., Cheung, P., Raz, A., Dennis, J.W., Nabi, I.R. Mol. Cell. Biol. (2006)
- Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection. Acosta-Rodríguez, E.V., Montes, C.L., Motrán, C.C., Zuniga, E.I., Liu, F.T., Rabinovich, G.A., Gruppi, A. J. Immunol. (2004)
- Expression and function of galectin-3, a beta-galactoside-binding protein in activated T lymphocytes. Joo, H.G., Goedegebuure, P.S., Sadanaga, N., Nagoshi, M., von Bernstorff, W., Eberlein, T.J. J. Leukoc. Biol. (2001)
- Embryonic implantation in galectin 1/galectin 3 double mutant mice. Colnot, C., Fowlis, D., Ripoche, M.A., Bouchaert, I., Poirier, F. Dev. Dyn. (1998)
- Differential cellular expression of galectin family mRNAs in the epithelial cells of the mouse digestive tract. Nio, J., Kon, Y., Iwanaga, T. J. Histochem. Cytochem. (2005)
- Immunohistochemical and in situ hybridization analysis of galectin-3, a beta-galactoside binding lectin, in the urinary system of adult mice. Nio, J., Takahashi-Iwanaga, H., Morimatsu, M., Kon, Y., Iwanaga, T. Histochem. Cell Biol. (2006)
- Critical role of galectin-3 in phagocytosis by macrophages. Sano, H., Hsu, D.K., Apgar, J.R., Yu, L., Sharma, B.B., Kuwabara, I., Izui, S., Liu, F.T. J. Clin. Invest. (2003)
- Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes. Ahmad, N., Gabius, H.J., André, S., Kaltner, H., Sabesan, S., Roy, R., Liu, B., Macaluso, F., Brewer, C.F. J. Biol. Chem. (2004)