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Gene Review: 

pknox1.2  -  pbx/knotted 1 homeobox 1.2

Danio rerio

Synonyms: knotted, pbx, prep1.2
 
 
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High impact information on pknox1.2

  • Notably, reductions in the function of another Hox cofactor, pbx, have not been reported to transform the caudal hindbrain, suggesting that Meis and Pbx proteins may also function differently in their roles as Hox cofactors [1].
  • A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b [2].
  • We present the characterization of a zebrafish pbx CDNA that appears to encode a novel family member, pbx4. pbx4 RNA is maternally deposited and is detected throughout the zebrafish embryo during blastula stages [2].
 

Biological context of pknox1.2

  • pbx genes encode homeodomain-containing transcriptional regulators that interact with other proteins to control embryogenesis and tumorigenesis [2].

References

  1. Paralog group 1 hox genes regulate rhombomere 5/6 expression of vhnf1, a repressor of rostral hindbrain fates, in a meis-dependent manner. Choe, S.K., Sagerström, C.G. Dev. Biol. (2004) [Pubmed]
  2. A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b. Vlachakis, N., Ellstrom, D.R., Sagerström, C.G. Dev. Dyn. (2000) [Pubmed]
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