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Gene Review

Peg10  -  paternally expressed 10

Mus musculus

Synonyms: AA407948, Edr, Embryonal carcinoma differentiation regulated protein, HB-1, MEF3-like protein 1, ...
 
 
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Disease relevance of Peg10

  • We isolated Gram-positive circular bacterium HB1 from intestinal microflora showing resistance to colonization by Clostridium difficile in mice (Su et. al., 1986a,b) [1].
 

High impact information on Peg10

  • To elucidate the functions of evolutionarily conserved retrotransposon-derived genes in mammalian development, we produced mice that lack one of these genes, Peg10 (paternally expressed 10), which is a paternally expressed imprinted gene on mouse proximal chromosome 6 [2].
  • Therefore these preneoplastic lesions were induced directly by HB1 myc and did not require the expression of Blym-1 or similar oncogenes [3].
  • The DNA from these transformed follicles contained the HB1 v-myc gene but lacked the ability to transform NIH/3T3 mouse cells [3].
  • Peg10, which is next to Sgce, shows complete paternal expression, like Sgce [4].
  • 5'-RACE (Rapid Amplification of cDNA Ends) analysis of Peg10 revealed the existence of a novel first exon separate from the second exon, which encoded two putative ORFs similar to the viral Gag and Pol proteins [4].
 

Biological context of Peg10

  • The use of short DNA fragments encompassing the nucleotide base substitutions across the MB1 domain in competition band shift assay revealed that the ten nucleotide sequence, 5'-GCCTGTCTTT-3' is important for binding of MyEF-3 to DNA [5].
  • Computer assisted evaluations of the MyEF-3 sequence revealed several interesting features including four sites for phosphorylation by casein kinase II, a transmembrane domain at the N-terminus, a nuclear localization signal and a Zinc finger domain at the carboxyl terminal [5].
  • Testing a reporter gene construct with mutated binding sites in mouse embryos shows that HB1 is also active in the expression domains of posterior Hox genes in the mouse neural tube [6].
  • Further study of the HB1 antigen may provide important information about the influence of the brain environment on the phenotype of monocytic cells [7].
 

Anatomical context of Peg10

  • Here, we report the isolation of a recombinant cDNA clone, termed myelin expression factor-3, (MyEF-3) from a mouse brain expression library that encodes a novel protein which interacts with the MBP MB1 domain [5].
  • Hybridization of a mouse T-cell lymphocyte line (HB1) with a polyoma virus-transformed mouse fibroblast line [8].
  • The monoclonal antibody HB1 recognizes an adhesion molecule for macrophages in the brain [7].
  • HB1 recognizes microglia in the normal brain and activated microglia and recruited monocytes during CNS pathology [7].
 

Other interactions of Peg10

  • MyEF-3, a developmentally controlled brain-derived nuclear protein which specifically interacts with myelin basic protein proximal regulatory sequences [5].
 

Analytical, diagnostic and therapeutic context of Peg10

  • Results from Northern blot studies demonstrate that expression of MyEF-3 is restricted to brain and developmentally regulated during brain maturation [5].

References

  1. Identification of a Clostridium cocleatum strain involved in an anti-Clostridium difficile barrier effect and determination of its mucin-degrading enzymes. Boureau, H., Decré, D., Carlier, J.P., Guichet, C., Bourlioux, P. Res. Microbiol. (1993) [Pubmed]
  2. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Ono, R., Nakamura, K., Inoue, K., Naruse, M., Usami, T., Wakisaka-Saito, N., Hino, T., Suzuki-Migishima, R., Ogonuki, N., Miki, H., Kohda, T., Ogura, A., Yokoyama, M., Kaneko-Ishino, T., Ishino, F. Nat. Genet. (2006) [Pubmed]
  3. A retroviral myc gene induces preneoplastic transformation of lymphocytes in a bursal transplantation assay. Neiman, P., Wolf, C., Enrietto, P.J., Cooper, G.M. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  4. Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Ono, R., Shiura, H., Aburatani, H., Kohda, T., Kaneko-Ishino, T., Ishino, F. Genome Res. (2003) [Pubmed]
  5. MyEF-3, a developmentally controlled brain-derived nuclear protein which specifically interacts with myelin basic protein proximal regulatory sequences. Steplewski, A., Krynska, B., Tretiakova, A., Haas, S., Khalili, K., Amini, S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  6. A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs. Keegan, L.P., Haerry, T.E., Crotty, D.A., Packer, A.I., Wolgemuth, D.J., Gehring, W.J. Mech. Dev. (1997) [Pubmed]
  7. The monoclonal antibody HB1 recognizes an adhesion molecule for macrophages in the brain. Brown, H., Townsend, M., Fearn, S., Perry, V.H. J. Neurocytol. (1998) [Pubmed]
  8. Hybridization of a mouse T-cell lymphocyte line (HB1) with a polyoma virus-transformed mouse fibroblast line. Berebbi, M., Foa, C., Barra, Y., Simonetti, J., Meyer, G. Exp. Cell Res. (1981) [Pubmed]
 
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