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Gene Review: 

Mutyh  -  mutY homolog (E. coli)

Rattus norvegicus

Synonyms: A/G-specific adenine DNA glycosylase, MutY homolog, Myh, rMYH
 
 
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Disease relevance of Mutyh

  • We show that the Escherichia coli MutY DNA glycosylase homolog (MYH) in rat (rMYH) involved in repair of oxidative damage is abundantly expressed in the rat brain, with isoforms that are exclusive to brain tissue [1].
  • Ensuing hypoxia, mitochondrial DNA damage was induced and rMYH expression strongly elevated [2].
 

High impact information on Mutyh

 

Analytical, diagnostic and therapeutic context of Mutyh

  • We have cloned a full-length rat MYH (rMYH) cDNA, which encodes 516 amino acids, and by in situ hybridization analysis obtained expression patterns of rMYH mRNA in hippocampal, cortical and cerebellar regions [2].

References

  1. Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain-specific isoforms that localize to neuronal mitochondria. Englander, E.W., Hu, Z., Sharma, A., Lee, H.M., Wu, Z.H., Greeley, G.H. J. Neurochem. (2002) [Pubmed]
  2. Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain. Lee, H.M., Wang, C., Hu, Z., Greeley, G.H., Makalowski, W., Hellmich, H.L., Englander, E.W. J. Neurochem. (2002) [Pubmed]
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