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CLYBL  -  citrate lyase beta like

Homo sapiens

Synonyms: CLB, Citrate lyase beta-like, Citrate lyase subunit beta-like protein, mitochondrial
 
 
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Disease relevance of CLYBL

  • Antibodies H5C6 and CLB/Gran12 immunoprecipitated a 30- to 60-Kd heterodisperse glycoprotein from G361 melanoma cells, as had previously been reported for antibodies recognizing ME491 [1].
  • However, their cells had a normal expression of other phosphatidylinositol (PI)-linked membrane glycoprotein (CD24, CD67, and CLB gran/5 antigens), ruling out the existence of a PI-linkage defect, such as paroxysmal nocturnal hemoglobinuria [2].
  • In a randomized trial, 227 patients undergoing hemodialysis who were seronegative for all markers of hepatitis B virus were immunized at monthly intervals with three doses of either 3 micrograms or 27 micrograms of heat-inactivated hepatitis B HB-vaccine (CLB) [3].
  • All lung cancer cell lines expressed Fas and FasL at RNA and protein levels, and apoptosis could be induced in four of six cell lines upon exposure to the Fas agonistic monoclonal antibody (mAb) CLB-CD95/15 [4].
  • FDR appears to be an efficient therapy with a favorable toxicity profile for patients in relapse after splenectomy or resistant to CLB [5].
 

High impact information on CLYBL

  • Furthermore, the anti-CD16 MoAbs CLB FcR gran1 (VD2) and OK-NK, which react with both T- and NK-lineage GLs, induced the proliferation of GLs with both T- and and NK-cell phenotypes [6].
  • Identity of CD63 and Pltgp40 was demonstrated by immunoprecipitation and sequential immunodepletion studies, which showed that the anti-Pltgp40 monoclonal antibody (MoAb) H5C6 and an anti-CD63 MoAb CLB/Gran 12 recognized the same 40- to 55-Kd platelet glycoprotein [1].
  • IgG1-mediated phagocytosis was blocked by mAb against hFc gamma RIIIb (CLB/FcRGran 1) to a greater extent than by anti-hFc gamma RIIa mAb [7].
  • METHODS: Radiolabeled CLB-CD19 antibody was evaluated for targeting ALL in a severe combined immunodeficient (SCID) mouse model engrafted with primary human leukemia cells [8].
  • STUDY DESIGN AND METHODS: Nucleic acids from 1-in-3 serial dilutions of an HCV RNA run control (Pelispy, CLB) were extracted with three kits (Cobas Amplicor, Roche Diagnostic Systems; BioRobot 9604, Qiagen; and NucliSens Extractor, Organon Teknika) [9].
 

Chemical compound and disease context of CLYBL

  • For this reason, the International Society for Chemo-Immunotherapy, Chronic Lymphocytic Leukemia Cooperative Group, has begun a randomized multicenter trial comparing Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen with continuous high dose chlorambucil (HD-CLB) [10].
  • The results showed that the time of second stage of labor and postpartum hemorrhage in the CLB group were less than those in the control group and the average intrauterine pressure in the former was higher than that in latter, so was the contraction strength of isolated uterine muscle, but with no difference as compared with the OTC group [11].
 

Biological context of CLYBL

  • Following 0.9 mg/kg iv and 9 mg/kg po doses, systemic blood clearance (CLB) and bioavailability (F) of L-738,372 were species-dependent and inversely related (CLB = 48, 15, and 3 ml/min/kg; F = 6, 62 and 94%, in dogs, rats, and monkeys, respectively) [12].
  • 4. In conclusion CL and CLB were reduced following treatment with LPS in a manner consistent with downregulation of both canalicular and sinusoidal transport [13].
  • It is concluded that CLB could obviously strengthen uterine contraction and accelerate second stage of labor [11].
  • To observe the clinical effects and the mechanism of Chanlibao (CLB, a preparation of Chinese herbal medicine) in accelerating second stage of labor, primiparae were divided into 3 groups at random [11].
  • Efficacy trial of heat-inactivated hepatitis B vaccine (CLB) in male homosexuals in the Netherlands [14].
 

Anatomical context of CLYBL

  • It is suggested that CLB is one of the characteristic ultrastructural features of the stromal cells [15].
  • The mitogenic activity of MoAb CLB-CD28/1 on PBMC does not require MoAb interaction with monocyte Fc receptors, since F(ab')2 fragments from the MoAb are mitogenic to the same extent as whole IgG [16].
  • Mitogenic activity of anti-CD28 MoAb CLB-CD28/1 on peripheral blood mononuclear cells and its cooperation with other anti-T cells MoAb in the activation of purified T lymphocytes [16].
  • Some stromal cells were markedly distended by numerous large vacuoles derived from CLB [15].
  • CLB were often present in the stromal cells with voluminous loose cytoplasm, particularly those close to the capillaries [15].
 

Associations of CLYBL with chemical compounds

  • We report here our quantitative data on the reactions of thiocyanate ion with CLB in various fluid matrixes at 37 degreesC [17].
  • Bear-1 (anti-CD11b monoclonal antibody) inhibited the histamine release enhanced by rIL-3, however SPV-L7 (anti-CD11a monoclonal antibody) or CLB-LFA1/1 (anti-CD18 monoclonal antibody) did not inhibit the histamine release enhanced by rIL-3 at all [18].
  • The renal clearance of cefotiam (CLR = 133 ml/min) was an order of magnitude greater than its biliary clearance (CLB = 11.8 ml/min) [19].
  • An anti-cancer drug (chlorambucil, CLB), which can form an inclusion complex with beta-CD, was selected for loading and in vitro release studies [20].
  • CLB or oxytocin (OTC) was given to the CLB group (n = 80) and the OTC group (n = 52) respectively [11].
 

Analytical, diagnostic and therapeutic context of CLYBL

  • To confirm an association of CLB with disease and identify risk factors for transmission, we conducted a case-control study of travellers and foreign residents at two outpatient clinics in Kathmandu, Nepal. Patients without diarrhoea were matched to CLB cases by clinic and date of visit [21].
  • Gamma-camera imaging detected the uptake of (111)In-CHX-A"-DTPA CLB-CD19 in enlarged tumor-bearing spleen of engrafted mice [8].
  • The safety and immunogenicity of a plasma-derived heat-inactivated hepatitis B vaccine (CLB) were evaluated in 471 healthy human volunteers, who, both in their occupations and in their private lives, had been at minimal risk of being infected with hepatitis B virus [22].
  • Women who underwent surgery for ectopic pregnancy had a 54% probability of becoming pregnant (cumulative pregnancy rate, CPR), and a 36% probability of giving birth to a child (cumulative livebirth rate, CLB) during the 3 years after surgery [23].
  • CLB/Gran 11 and Leu 11c reactivities with PMN and NK cells from a selected panel of male donors were compared with enzyme-linked immunosorbent assay reactivities of CLB/Gran 11 and Leu 11c with SP samples from these donors [24].

References

  1. CD63/Pltgp40: a platelet activation antigen identical to the stage-specific, melanoma-associated antigen ME491. Azorsa, D.O., Hyman, J.A., Hildreth, J.E. Blood (1991) [Pubmed]
  2. Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia. Huizinga, T.W., Kuijpers, R.W., Kleijer, M., Schulpen, T.W., Cuypers, H.T., Roos, D., von dem Borne, A.E. Blood (1990) [Pubmed]
  3. Immune response to a heat-inactivated hepatitis B vaccine in patients undergoing hemodialysis. Enhancement of the response by increasing the dose of hepatitis B surface antigen from 3 to 27 micrograms. Lelie, P.N., Reesink, H.W., de Jong-van Manen, S.T., Dees, P.J., Reerink-Brongers, E.E. Arch. Intern. Med. (1985) [Pubmed]
  4. Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway. Ferreira, C.G., Tolis, C., Span, S.W., Peters, G.J., van Lopik, T., Kummer, A.J., Pinedo, H.M., Giaccone, G. Clin. Cancer Res. (2000) [Pubmed]
  5. Fludarabine: an effective treatment in patients with splenic lymphoma with villous lymphocytes. Lefrère, F., Hermine, O., Belanger, C., François, S., Tilly, H., Lebas de La Cour, J.C., Valensi, F., Varet, B., Troussard, X. Leukemia (2000) [Pubmed]
  6. Activation via the CD3 and CD16 pathway mediates interleukin-2-dependent autocrine proliferation of granular lymphocytes in patients with granular lymphocyte proliferative disorders. Hoshino, S., Oshimi, K., Teramura, M., Mizoguchi, H. Blood (1991) [Pubmed]
  7. Phagocytosis of Staphylococcus aureus and Haemophilus influenzae type B opsonized with polyclonal human IgG1 and IgG2 antibodies. Functional hFc gamma RIIa polymorphism to IgG2. Bredius, R.G., de Vries, C.E., Troelstra, A., van Alphen, L., Weening, R.S., van de Winkel, J.G., Out, T.A. J. Immunol. (1993) [Pubmed]
  8. Targeting primary human Ph(+) B-cell precursor leukemia-engrafted SCID mice using radiolabeled anti-CD19 monoclonal antibodies. Mitchell, P., Lee, F.T., Hall, C., Rigopoulos, A., Smyth, F.E., Hekman, A.M., van Schijndel, G.M., Powles, R., Brechbiel, M.W., Scott, A.M. J. Nucl. Med. (2003) [Pubmed]
  9. Evaluation of automated nucleic acid extraction devices for application in HCV NAT. Jongerius, J.M., Bovenhorst, M., van der Poel, C.L., van Hilten, J.A., Kroes, A.C., van der Does, J.A., van Leeuwen, E.F., Schuurman, R. Transfusion (2000) [Pubmed]
  10. High dose chlorambucil versus Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone regimen in the treatment of patients with advanced B-cell chronic lymphocytic leukemia. Results of an international multicenter randomized trial. International Society for Chemo-Immunotherapy, Vienna. Jaksic, B., Brugiatelli, M., Krc, I., Losonczi, H., Holowiecki, J., Planinc-Peraica, A., Kusec, R., Morabito, F., Iacopino, P., Lutz, D. Cancer (1997) [Pubmed]
  11. Clinical effects and mechanism of chanlibao in accelerating second stage of labor. Qiu, H., Zhu, H., Ouyang, W., Wang, Z., Sun, H. J. Tongji Med. Univ. (1999) [Pubmed]
  12. Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human. Prueksaritanont, T., Balani, S.K., Dwyer, L.M., Ellis, J.D., Kauffman, L.R., Varga, S.L., Pitzenberger, S.M., Theoharides, A.D. Drug Metab. Dispos. (1995) [Pubmed]
  13. Alteration of fexofenadine disposition in the rat isolated perfused liver following injection of bacterial lipopolysaccharide. Tong, Y., Zhang, R., Ngo, S.N., Davey, A.K. Clin. Exp. Pharmacol. Physiol. (2006) [Pubmed]
  14. Efficacy trial of heat-inactivated hepatitis B vaccine (CLB) in male homosexuals in the Netherlands. Coutinho, R.A., Lelie, P.N., Albrecht-van Lent, P., Stoutjesdijk, L., Huisman, J., Kuipers, H., Schut, L.J., Reerink-Brongers, E.E., Reesink, H.W., van Aken, W.G. Dev. Biol. Stand. (1983) [Pubmed]
  15. Ultrastructure of cerebellar capillary hemangioblastoma. VI. Concentric lamellar bodies of endoplasmic reticulum in stromal cells. Ho, K.L. Acta Neuropathol. (1987) [Pubmed]
  16. Mitogenic activity of anti-CD28 MoAb CLB-CD28/1 on peripheral blood mononuclear cells and its cooperation with other anti-T cells MoAb in the activation of purified T lymphocytes. De Felice, M., Giarrusso, P.C., Lamberti, A., Turco, M.C., Valerio, G., van Lier, R.A., Yang, S.Y., Ferrone, S., Venuta, S. Tissue Antigens (1990) [Pubmed]
  17. Role of thiocyanate ion in detoxification of the anticancer agent chlorambucil. Hovinen, J., Pettersson-Fernholm, T., Lahti, M., Vilpo, J. Chem. Res. Toxicol. (1998) [Pubmed]
  18. Effects of anti-CD11a, anti-CD11b and anti-CD18 on histamine release from human basophils primed with IL-3. Watanabe, A., Tominaga, T., Tsuji, J., Yanagihara, Y., Koda, A. Int. Arch. Allergy Immunol. (1992) [Pubmed]
  19. Pharmacokinetics and quantitative characterization of cefotiam excretion after intravenous administration to patients after cholecystectomy. Terziivanov, D., Gerova, Z., Vlahov, V., Merdzhanov, A., Damjanov, D. Eur. J. Clin. Pharmacol. (1986) [Pubmed]
  20. Release of chlorambucil from poly(N-isopropylacrylamide) hydrogels with beta-cyclodextrin moieties. Liu, Y.Y., Fan, X.D., Hu, H., Tang, Z.H. Macromolecular bioscience. (2004) [Pubmed]
  21. Epidemiology of diarrhoeal illness associated with coccidian-like organism among travellers and foreign residents in Nepal. Hoge, C.W., Shlim, D.R., Rajah, R., Triplett, J., Shear, M., Rabold, J.G., Echeverria, P. Lancet (1993) [Pubmed]
  22. Immunogenicity and safety of a plasma-derived heat-inactivated hepatitis B vaccine (CLB). Studies in volunteers at a low risk of infection with hepatitis B virus. Lelie, P.N., Reesink, H.W., de Jong-van Manen, S.T., Dees, P.J., Reerink-Brongers, E.E. Am. J. Epidemiol. (1984) [Pubmed]
  23. Determinants of reproductive prognosis after ectopic pregnancy. Gruft, L., Bertola, E., Luchini, L., Azzilonna, C., Bigatti, G., Parazzini, F. Hum. Reprod. (1994) [Pubmed]
  24. Immunogenetic studies of soluble Fc receptor (CD16) antigens in human seminal plasma. Thaler, C.J., McIntyre, J.A., Faulk, W.P. Tissue Antigens (1991) [Pubmed]
 
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