Gene Review:
Mc3r - melanocortin 3 receptor
Mus musculus
Synonyms:
MC3-R, Melanocortin receptor 3
- Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. Getting, S.J., Christian, H.C., Lam, C.W., Gavins, F.N., Flower, R.J., Schiöth, H.B., Perretti, M. J. Immunol. (2003)
- A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Butler, A.A., Kesterson, R.A., Khong, K., Cullen, M.J., Pelleymounter, M.A., Dekoning, J., Baetscher, M., Cone, R.D. Endocrinology (2000)
- Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Chen, A.S., Marsh, D.J., Trumbauer, M.E., Frazier, E.G., Guan, X.M., Yu, H., Rosenblum, C.I., Vongs, A., Feng, Y., Cao, L., Metzger, J.M., Strack, A.M., Camacho, R.E., Mellin, T.N., Nunes, C.N., Min, W., Fisher, J., Gopal-Truter, S., MacIntyre, D.E., Chen, H.Y., Van der Ploeg, L.H. Nat. Genet. (2000)
- MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. Getting, S.J., Di Filippo, C., Christian, H.C., Lam, C.W., Rossi, F., D'Amico, M., Perretti, M. J. Leukoc. Biol. (2004)
- Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity. Feng, N., Young, S.F., Aguilera, G., Puricelli, E., Adler-Wailes, D.C., Sebring, N.G., Yanovski, J.A. Diabetes (2005)
- Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains. Gelegen, C., Collier, D.A., Campbell, I.C., Oppelaar, H., Kas, M.J. Am. J. Physiol. Endocrinol. Metab. (2006)
- Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Butler, A.A., Marks, D.L., Fan, W., Kuhn, C.M., Bartolome, M., Cone, R.D. Nat. Neurosci. (2001)
- A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Ste Marie, L., Miura, G.I., Marsh, D.J., Yagaloff, K., Palmiter, R.D. Proc. Natl. Acad. Sci. U.S.A. (2000)
- A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. Benoit, S.C., Schwartz, M.W., Lachey, J.L., Hagan, M.M., Rushing, P.A., Blake, K.A., Yagaloff, K.A., Kurylko, G., Franco, L., Danhoo, W., Seeley, R.J. J. Neurosci. (2000)
- A possible involvement of melanocortin 3 receptor in the regulation of adrenal gland function in the chicken. Takeuchi, S., Takahashi, S. Biochim. Biophys. Acta (1999)
- Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Sutton, G.M., Trevaskis, J.L., Hulver, M.W., McMillan, R.P., Markward, N.J., Babin, M.J., Meyer, E.A., Butler, A.A. Endocrinology (2006)
- [D-Trp8]-{gamma}-Melanocyte-Stimulating Hormone Exhibits Anti-Inflammatory Efficacy in Mice Bearing a Nonfunctional MC1R (Recessive Yellow e/e Mouse). Getting, S.J., Lam, C.W., Leoni, G., Gavins, F.N., Grieco, P., Perretti, M. Mol. Pharmacol. (2006)
- Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin. Zhang, Y., Kilroy, G.E., Henagan, T.M., Prpic-Uhing, V., Richards, W.G., Bannon, A.W., Mynatt, R.L., Gettys, T.W. FASEB J. (2005)
- Cat odour exposure decreases exploratory activity and alters neuropeptide gene expression in CCK(2) receptor deficient mice, but not in their wild-type littermates. Areda, T., Raud, S., Philips, M.A., Innos, J., Matsui, T., Kõks, S., Vasar, E., Karis, A., Asser, T. Behav. Brain Res. (2006)
- Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor. Navarro, M., Cubero, I., Chen, A.S., Chen, H.Y., Knapp, D.J., Breese, G.R., Marsh, D.J., Thiele, T.E. Alcohol. Clin. Exp. Res. (2005)
- Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position. Holder, J.R., Bauzo, R.M., Xiang, Z., Haskell-Luevano, C. J. Med. Chem. (2002)
- Effect of estrogen on melanocortin-3 receptor mRNA expression in mouse pituitary glands in vivo and in vitro. Matsumura, R., Takeuchi, S., Takahashi, S. Neuroendocrinology (2004)
- Elongation studies of the human agouti-related protein (AGRP) core decapeptide (Yc[CRFFNAFC]Y) results in antagonism at the mouse melanocortin-3 receptor. Joseph, C.G., Bauzo, R.M., Xiang, Z., Shaw, A.M., Millard, W.J., Haskell-Luevano, C. Peptides (2003)
- Melanocortin receptors mediate alpha-MSH-induced stimulation of neurite outgrowth in neuro 2A cells. Adan, R.A., van der Kraan, M., Doornbos, R.P., Bär, P.R., Burbach, J.P., Gispen, W.H. Brain Res. Mol. Brain Res. (1996)
- The genes for endothelin 3, vitamin D 24-hydroxylase, and melanocortin 3 receptor map to distal mouse chromosome 2, in the region of conserved synteny with human chromosome 20. Malas, S., Peters, J., Abbott, C. Mamm. Genome (1994)
- Alpha-melanocyte-stimulating hormone stimulates prolactin secretion through melanocortin-3 receptors expressed in mammotropes in the mouse pituitary. Matsumura, R., Takagi, C., Kakeya, T., Okuda, K., Takeuchi, S., Takahashi, S. Neuroendocrinology (2003)
- Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. Getting, S.J., Allcock, G.H., Flower, R., Perretti, M. J. Leukoc. Biol. (2001)