High impact information on cye-1

• The level of cyclin E (cye-1) expression is critical for nuclear divisions in the intestine and is elevated in double mutants in lin-35 and RNA interference pathway genes [1].
• We have identified strong loss-of-function mutations in the C. elegans cyclin E gene, cye-1 [2].
• In addition, cye-1 is required maternally, but not zygotically for embryonic development [2].
• Our analysis of a new cye-1 deletion allele confirms and extends previous studies of two point mutations in the gene [3].

Biological context of cye-1

• Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development [2].

Analytical, diagnostic and therapeutic context of cye-1

• Finally, we find that TGF-beta (DBL-1) and cyclin E (CYE-1) regulate body size via endoreduplication [4].

References